Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis

Genetic Basis of Atherosclerosis: Part II

“…29 In the pravastatin-randomized patients in the REGRESS trial, the risk of clinical events was associated with a common polymorphism in the promotor of the matrix metalloproteinase stromelysin-1 gene. 30 These effects were independent of the effects of pravastatin on lipid levels.…”

Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease

“…The most studied MMP SNP is the MMP-3 gene 5A/6A variant ( [10][11][12][13][14]18,19,[21][22][23] ) and only a few have not found a disease association ( 19 ). While all studies of MMP-3 evaluated the 5A/ 6A promoter SNP, only two have evaluated other MMP-3 SNPs and in those the 5A/6A SNP was as good or better at risk stratification than the others.…”

“…While all studies of MMP-3 evaluated the 5A/ 6A promoter SNP, only two have evaluated other MMP-3 SNPs and in those the 5A/6A SNP was as good or better at risk stratification than the others. ( 22,23 ) Prior studies of MMP-3 have found increased risk associated with both the 5A ( 11,13,14,18,21,22 ) and the 6A ( 10,12,13,23,26,27 ) allele, or no association ( 19 ), but the phenotypes studied therein included MI ( 11,14,(21)(22)(23)27 ), CAD presence ( 23 ), CAD progression ( 10,12 ), coronary aneurysm ( 18 ), patient-reported symptoms and CAD history ( 19 ), cardiac events ( 13 ), and CAD score ( 14 ).…”

“…Variation in genes encoding MMPs and TIMPs may be associated with cardiovascular disease ( [10][11][12][13][14][15][16][17] ), but few studies have examined more than one gene or even more than one SNP. ( [18][19][20][21][22][23][24][25] This study evaluated the association of SNPs in the genes encoding MMP-1, MMP-2, MMP-3, MMP-9, TIMP-1, TIMP-2, and TIMP-3 with MI among patients undergoing coronary angiography.…”

Interleukin 10: a new risk marker for the development of restenosis after percutaneous coronary intervention

“…[3][4][5] Several inflammatory genes have already been reported to be associated with the development of restenosis. 6,7 However, little is known about the involvement of anti-inflammatory cytokines, although they seem logic candidate genes in the process of restenosis. Interleukin 10 (IL-10) is one of these anti-inflammatory genes.…”