Effect of the subdermal contraceptive etonogestrel implant (Implanon®) on biochemical and hormonal parameters (three years follow-up)

İnal, Mehmet Murat; Yıldırım, Yusuf; Ertopcu, Kenan; Avcı, Meltem; Özelmas, İsa; Tınar, Şivekar

doi:10.1080/13625180802075315

Cited by 32 publications

(10 citation statements)

References 15 publications

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“…In contrast with the injectable depot medroxyprogesterone acetate, which suppresses ovarian estradiol production, estradiol levels remain physiologic in ENG implant users. 62,63 Accordingly, loss of bone mineral density would not be anticipated in users. Few high-quality studies have assessed ENG implant-associated changes in BMD and none have examined adolescents, whose use of hormonal contraceptives during peak bone mineral density accrual has attracted attention.…”

Section: Bone Densitymentioning

confidence: 99%

Best Practices for Counseling Adolescents about the Etonogestrel Implant

Berlan

Richards

Vieira

et al. 2020

Journal of Pediatric and Adolescent Gynecology

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Among young persons, ease of use, high efficacy, and high acceptability makes the etonogestrel (ENG) contraceptive implant an important choice for this age group. Adolescent-friendly, patient-centered counseling considers the patient's cognitive development, the influence of friends and family, as well as their own preferences and values. Age appropriate language, graphics and models are useful to explain contraceptive options and relevant side effects. Effectiveness, reversibility, safety, non-contraceptive benefits, and side effects are important attributes and should be discussed when teens are choosing a contraceptive method. This review describes suggested best practices for counseling adolescents about the ENG implant so they can make informed, prudent decisions about using this contraceptive method.

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Section: Bone Densitymentioning

confidence: 99%

Best Practices for Counseling Adolescents about the Etonogestrel Implant

Berlan

Richards

Vieira

et al. 2020

Journal of Pediatric and Adolescent Gynecology

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“…These changes cannot be considered as adverse effects because the levels were always within normal ranges. Fortunately, this pattern of non-adverse effects remains similar when the SCI is used for longer periods of time [35]. …”

Section: Discussionmentioning

confidence: 99%

Metabolic effects of the contraceptive skin patch and subdermal contraceptive implant in Mexican women: A prospective study

et al. 2014

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BackgroundThe contraceptive skin patch (CSP) accepted by the U.S. FDA in 2001 includes ethinylestradiol and norelgestromine, whereas the subdermal contraceptive implant (SCI) has etonogestrel and is also approved by the FDA. In Mexico, both are now widely used for contraception but their effects on Mexican population are unknown. The objective of the study was to evaluate if these treatments induce metabolic changes in a sample of indigenous and mestizo Mexican women.MethodsAn observational, prospective, longitudinal, non-randomized study of women between 18 and 35 years of age assigned to CSP or SCI. We performed several laboratory tests: clinical chemistry, lipid profile, and liver and thyroid function tests. Also, serum levels of insulin, C-peptide, IGF-1, leptin, adiponectin, and C reactive protein were assayed.ResultsSixty-two women were enrolled, 25 used CSP (0 indigenous; 25 mestizos) and 37 used SCI (18 indigenous; 19 mestizos). Clinical symptoms were relatively more frequent in the SCI group. Thirty-four contraceptive users gained weight without other clinical significant changes. After 4 months of treatment, significant changes were found in some biochemical parameters in both treatment groups. Most were clinically irrelevant. Interestingly, the percentage of users with an abnormal atherogenic index diminished from 75% to 41.6% after follow-up.ConclusionsThe CSP slightly modified the metabolic variables. Most changes were nonsignificant, whereas for SCI users changes were more evident and perhaps beneficial. Results of this attempt to evaluate the effects of contraceptives in mestizo and native-American populations show that clinical symptoms are frequent in Mexican users of CSP and SCI. Although these medications may affect some metabolic variables, these changes seem clinically irrelevant. Induction of abnormalities in other physiological pathways cannot be ruled out.

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“…Contrary to the above trials, Funk and colleagues16 reported no significant change in liver function parameters over a two-year use of the ENG implant. Additionally, Inal and colleagues11 found no significant difference between baseline and end-of-study serum glutamic oxalate transaminase, serum glutamic pyruvic transaminase, fasting glucose, HDL, cholesterol, or triglycerides. The mixed results suggest that there may be a small amount of liver dysfunction in ENG implant users.…”

Section: Safety and Side Effect Profilementioning

confidence: 94%

Examining the efficacy, safety, and patient acceptability of the etonogestrel implantable contraceptive

Hohmann¹

2009

PPA

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Contraceptive implants provide long-acting, highly effective reversible contraception. The etonogestrel implant (ENG implant) is a single rod implant that offers three years of efficacy. The ENG implant was designed to provide contraceptive efficacy by inhibiting ovulation and Pearl Index scores reported for this method are similar to other long-acting reversible contraception as well as similar to sterilization. The implant has been shown to be safe during breast feeding and may improve symptoms of dysmenorrhea and endometriosis. Irregular bleeding patterns can be expected with the device’s use and should be addressed in order to decrease rates of discontinuation.

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Effect of the subdermal contraceptive etonogestrel implant (Implanon®) on biochemical and hormonal parameters (three years follow-up)

Abstract: Our findings confirm data from the literature according to which Implanon does not affect meaningfully reproductive hormonal parameters, thyroid function, hepatic and renal functions, and glucose metabolism. However, further studies are needed to elucidate lipid metabolism changes.

Cited by 32 publications

References 15 publications

Best Practices for Counseling Adolescents about the Etonogestrel Implant

Best Practices for Counseling Adolescents about the Etonogestrel Implant

Metabolic effects of the contraceptive skin patch and subdermal contraceptive implant in Mexican women: A prospective study

Examining the efficacy, safety, and patient acceptability of the etonogestrel implantable contraceptive

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