Effect of the supplementation of virgin coriander seed oil on reducing reactivity in healthy women with sensitive skin: a randomized double-blind placebo-controlled pilot clinical study

Abstract

Sensitive skin is a common condition that affects many people in the world, especially women. This syndrome is defined by the occurrence of unpleasant sensations such as stinging and burning in response to stimuli that should not normally provoke such sensations. Coriander seed oil (CSO) is a 100% virgin oil of coriander seeds and boasts a specific composition of fatty acids, mainly petroselinic acid (60–75%). It has demonstrated its ability to regulate inflammation (NF-κB pathway) and nociception (TRPA1 pathway), two mechanisms supporting sensitive skin, in previous in vitro research. It was, therefore, a good candidate to be tested in vivo on sensitive skin conditions. A pilot clinical study was conducted to evaluate the effect of this ingredient on healthy women showing excessive skin reactions, mainly redness and discomfort when subjected to external stress. The results showed that the daily consumption of 200 mg of CSO for 28 days effectively reduced redness induced by stripping stress and itching induced by stinging stress. It also improved the perception of skin sensitivity and reactivity after 56 days of consumption. These clinical results confirmed that CSO is a promising ingredient to contribute to reducing reactivity in sensitive skin.

A mechanism of melanogenesis mediated by E‐cadherin downregulation and its involvement in solar lentigines

“…In cultured keratinocytes, downregulation of E-cadherin promoted various downstream age-spot processes: the secretion of melanocytic/inflammatory factors, melanogenesis, detained melanocyte dynamics and melanin-uptake. To find a solution that can upregulate E-cadherin expression, 32 ingredients, which are known to have efficacies on cell-cell-contact-related functions, were selected for the screening [32][33][34]. Among them, we identified Rosa multiflora fruit extract as a solution for upregulating E-cadherin in keratinocytes.…”

“…Among 211 ingredients of plant extracts, vegetable oils and chemical compounds, the ingredients were first selected based on efficacies of ingredients that promote cell adhesion, keratinocyte differentiation, or barrier function. Among them, 32 ingredients such as Rosa multiflora fruit extract, Calendula officinalis flower extract, Coriandrum sativum fruit extract and xylitol were selected and utilized for the screening [32][33][34][35]. Keratinocytes were seeded into a 12-well plate, at a cell density of 3 × 10 4 cells/well, and cultured for 48 h. Following that, individual ingredients (0.005%) diluted in dimethyl sulfoxide were added to the cells.…”

“…Since E-cadherin is involved in cell-cell contact and keratinocyte differentiation, we first considered ingredients, which promote cell adhesion, keratinocyte differentiation, or barrier function, may have a potential upregulating Ecadherin expression. In total, 32 ingredients such as Rosa multiflora fruit extract, Calendula officinalis flower extract and Coriandrum sativum fruit extract were selected and utilized for the screening [32][33][34][35]. Samples obtained after treating the cultured keratinocytes with various percentages of ingredients were subjected to qPCR, which identified that 0.005% Rosa multiflora fruit extract upregulated E-cadherin mRNA expression to 1.2-fold of that observed in the control (Figure 8a).…”

Edible Oils from Selected Unconventional Sources—A Comprehensive Review of Fatty Acid Composition and Phytochemicals Content

“…Proper identification of oleic/petroselinic acid is a significant challenge for scientists since these fatty acids differ in biological activities. For example, a recent clinical study confirmed that coriander seed oil (abundant in petroselinic acid) regulates human body inflammation and nociception and thus reduces reactivity in sensitive skin [223].…”