Effect of the Synthetic Approach on the Formation and Magnetic Properties of Iron-Based Nanophase in Branched Polyester Polyol Matrix

Khannanov, Artur; Burmatova, Anastasia; Ignatyeva, Klara A.; Vagizov, F. G.; Kiiamov, Airat; Tayurskiı̆, D. A.; Черосов, М.А.; Gerasimov, Alexander V.; Vladimir, Evtugyn; Кутырева, М. П.

doi:10.3390/ijms232314764

Cited by 7 publications

(9 citation statements)

References 89 publications

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“…Previously, in our studies, it was shown that hyperbranched polyester polyols are good stabilizers in the formation of composite nanoparticles of a number of biophilic metals (copper [40], iron [43], and cobalt [41]) via the chemical recovery method, using hydrazine hydrate or sodium borohydride as active reducing agents. Among the synthesized nanomaterials, superparamagnetic polyol-stabilized cobalt nanoparticles are of particular interest as they can be used as multifunctional nanocomposites for biomedicine, advanced technologies, and theranostics.…”

Section: Introductionmentioning

confidence: 89%

“…The temperature in the chamber was determined using a contact thermometer OMEGA HH804 (Engineering Inc., Norwalk, CT, USA) for all measurements. For the spectra fitting, the OriginPro program package was used; the Gauss function was used throughout [43].…”

Section: Equipmentmentioning

confidence: 99%

“…The results are expressed as mean ± standard deviation, n = 5. The value of HC 50 corresponded to the concentration of CoNPs, at which 50% hemolysis of erythrocytes was observed [43].…”

Section: Hemolysis Assaymentioning

confidence: 99%

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A Hyperbranched Polyol Process for Designing and Manufacturing Nontoxic Cobalt Nanocomposite

Burmatova,

Khannanov,

Gerasimov

et al. 2023

Polymers

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A method for the design and synthesis of a metallopolymer composite (CoNP) based on cobalt nanoparticles using the hyperbranched polyol process was developed. It was shown that hyperbranched polyester polyols in a melted state can be both a reducing agent and a stabilizer of metal nanoparticles at the same time. The mechanism of oxidation of hyperbranched polyol was studied using diffuse reflectance IR spectroscopy. The process of oxidation of OH groups in G4-OH started from 90 °C and finished with the oxidation of aldehyde groups. The composition and properties of nanomaterials were determined with FT-IR and UV-Vis spectroscopy, Nanoparticle Tracking Analysis (NTA), thermogravimetric analysis (TG), powder X-ray diffraction (XRD), NMR relaxation, and in vitro biological tests. The cobalt-containing nanocomposite (CoNP) had a high colloidal stability and contained spheroid polymer aggregates with a diameter of 35–50 nm with immobilized cobalt nanoparticles of 5–7 nm. The values of R2 and R1 according to the NMR relaxation method for CoNPs were 6.77 mM·ms−1 × 10−5 and 4.14 mM·ms−1 × 10−5 for, respectively. The ratio R2/R1 = 0.61 defines the cobalt-containing nanocomposite as a T1 contrast agent. The synthesized CoNPs were nonhemotoxic (HC50 > 8 g/mL) multifunctional reagents and exhibited the properties of synthetic modulators of the enzymatic activity of chymosin aspartic proteinase and exhibited antimycotic activity against Aspergillus fumigatus. The results of the study show the unique prospects of the developed two-component method of the hyperbranched polyol process for the creation of colloidal multifunctional metal–polymer nanocomposites for theranostics.

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Section: Introductionmentioning

confidence: 89%

Section: Equipmentmentioning

confidence: 99%

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A Hyperbranched Polyol Process for Designing and Manufacturing Nontoxic Cobalt Nanocomposite

Burmatova,

Khannanov,

Gerasimov

et al. 2023

Polymers

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“…To increase the statistical dose, the sample was pumped through the measuring chamber by using a piezoelectric dispenser. Each sample was detected sequentially six times; the recording time was sequential and amounted to 60 s. For processing the footage of the Nanosight instrument, NTA 2.3 software applications (build 0033) and OriginPro program package were used; the Gaussian function was used throughout, as described previously. , The detailed work is currently presented in the Principle of Operation by Carr and Malloy. , The hydrodynamic size meter ( D h ) was calculated with the measurement of the two-dimensional Einstein–Stokes equation …”

Section: Materials and Methodsmentioning

confidence: 99%

Hybrid Nanostructures of Hyperbranched Polyester Loaded with Gd(III) and Dy(III) Ions

Kutyreva,

Vagapova,

Maksimov

et al. 2024

ACS Appl. Polym. Mater.

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Hyperbranched polymers are successful nanoscale functional platforms for loading metal ions and creating promising nanomaterials for medicine. This work presents the synthesis of metal−polymer nanostructures based on a second generation hyperbranched polyester with eight terminal benzoylthiocarbamate (BTC) groups loaded with Gd(III) or Dy(III) ions. Their structure (Fourier transform infrared spectroscopy) and morphology (transmission electron microscopy), photophysical (ultraviolet−visible and luminescence spectroscopy), thermophysical, magnetic activity, relaxivity, and aggregation properties (nanoparticle tracking analysis) were studied. The formation of the metal−polymer complex is carried out by chelation of lanthanide ions −C�O and −C�S groups of the BTC fragment of polyester. Coordination units with composition Ln(III)-3BTC (Ln = Dy, Gd) were localized on the branched polymer platform. The load is three lanthanide ions per branched polyester polybenzoylthiocarbamate macromolecule. Logarithms of stability constants of complexes and composition of coordination polyhedron have been determined. The dysprosium complex is in a paramagnetic state with antiferromagnetic correlations, and the gadolinium complex is in a paramagnetic state. The relaxivity of the Dy(III) and Gd(III) complexes increased by 2.5 and 3 times, respectively, compared to their nitrates. An important achievement is the identification of rare-earth metal (REM)-controlled morphology and self-organization for Dy(III) and Gd(III) complexes with branched polyester polybenzoylthiocarbamate in solution and on the surface. Spherical nanostructures for the dysprosium complex and nanorods for the gadolinium complex were observed. Synthesized REM-loaded nanostructures with polyester polybenzoylthiocarbamates have low hemotoxicity and can be applied in biomedicine.

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“…To increase the statistical dose, the sample was pumped through the measuring chamber using a piezoelectric dispenser. Each sample was detected sequentially 6 times; the total recording time was 60 s. For processing the footage from the Nanosight instrument, NTA 2.3 (build 0033) and OriginPro software were used; the Gauss function was employed as described previously [27,28]. The detailed procedures are described elsewhere [29,30].…”

Section: Equipmentmentioning

confidence: 99%

Towards controlling the morphology of cobalt loaded nanocomposites in polyol process with polyethylene glycol

Burmatova,

Khannanov,

Zubaidullina

et al. 2023

Chim.Tech.Acta

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The polyol process is one of the simple, efficient and productive methods for the synthesis of metal loaded polymer composites. Functional properties of metal-polymer nanocomposites are determined by chemical composition, size and morphology of their particles. Finding effective ways to control the nanoparticle's properties during the polyol process is a crucial task. The effect of molar ratio Mn+/OHPEG on the formation of cobalt loaded metal-polymer nanocomposites during a one-pot two-component polyol process by polyethylene glycol with Mr = 4000 g·mol–1 (PEG) was studied. The PEG-based polyol process and the formation of cobalt nanophase were studied at molar ratios νCo2+/νOH(PEG) = 1:1, 1:10, 1:100 and 1:500 using UV-Vis, diffuse reflectance IR and ATR FT-IR spectroscopy, nanoparticle tracking analysis (NTA), dynamic light scattering (DLS). It was found that PEG can act as a reducing agent and stabilizing matrix for the cobalt nanophase at a ratio higher than Mn+/OHPEG= 1:10. The composition and morphology of Co/PEG nanocomposites were determined by XRD and TEM methods. Two types of spheroid particles with average diameters of 88±55 nm / 8±4 nm and 12±3 nm / 3±1 nm, respectively, represent Co/PEG nanocomposites 1:500 and 1:100. Scaly structures with a diameter of 15±5 nm are formed at a molar ratio of νCo2+/νOH(PEG) = 1:10. An increase in the Co2+ content in the PEG-based polyol process leads to the immobilized cobalt nanophase Co3O4 (1:500), Co0/CoO (1:100), CoO (1:10) in PEG. Co/PEG nanocomposites are hemocompatible. The HC50value depends on the composition and morphology of the nanoparticles.

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Effect of the Synthetic Approach on the Formation and Magnetic Properties of Iron-Based Nanophase in Branched Polyester Polyol Matrix

Cited by 7 publications

References 89 publications

A Hyperbranched Polyol Process for Designing and Manufacturing Nontoxic Cobalt Nanocomposite

A Hyperbranched Polyol Process for Designing and Manufacturing Nontoxic Cobalt Nanocomposite

Hybrid Nanostructures of Hyperbranched Polyester Loaded with Gd(III) and Dy(III) Ions

Towards controlling the morphology of cobalt loaded nanocomposites in polyol process with polyethylene glycol

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