Effect of the time for embryo transfer from oocyte retrieval on clinical outcomes in freeze-all cycles: a retrospective cohort study

Chen, Shiping; Yao, Yachao; Luo, Yang; Mao, Yuling; Liu, Hanyan; Du, Hong; Kang, Xiangjin; Li, Lei

doi:10.1007/s00404-019-05405-4

Cited by 7 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We did not record the cycles that were canceled due to ovulation disorders. Our study concluded that immediate FET and delayed FET showed comparable live birth rates for different embryo types, embryo numbers, and different endometrial preparation protocols, which is consistent with the findings of other studies ( 1 , 6 ). Therefore, there is no evidence to support the necessity for routine delay of at least one menstrual cycle after IVF/ICSI before FET.…”

Section: Discussionsupporting

confidence: 91%

“…COH may lead to ovarian hyperstimulation syndrome (OHSS), cause endometrial synchronicity and other adverse factors that could reduce pregnancy rates, such as elevated progesterone and tubal effusion. Nearly half of the patients receiving COH undergo resuscitation transplantation after embryo freezing (1)(2)(3)(4). Patients undergoing in vitro fertilization (IVF) are eager to get pregnant with shortened interval between egg retrieval and transplantation.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have not come to a definitive conclusion on how immediate or delayed resuscitation will benefit pregnancy rates ( 8 , 9 ). Additionally, many of the retrospective studies on this issue were conducted in years ago, and the results of these studies may be biased against changes in the existing COH protocols ( 1 , 10 , 11 ). Therefore, owing to the advantage of large data volumes at our hospital, we retrospectively analyzed the clinical data of patients who underwent COH and resuscitation transplantation from October 2019 to August 2021.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of interval between oocyte retrieval and resuscitation embryo transfer on pregnancy outcomes

Wan

Chen

Wang³

et al. 2023

Front. Med.

View full text Add to dashboard Cite

ObjectivesResuscitation transfer of embryos after elective cryopreservation has been widely applied in in vitro fertilization-embryo transfer (IVF-ET) therapy for human infertility or sterility owing to higher embryo implantation rates. This method separates oocyte retrieval from embryo transfer. The optimal time for frozen embryo transfer (FET) remains unknown. Therefore, this study mainly compares the advantages and disadvantages of delayed FET and immediate FET through retrospective analysis.MethodsWe analyzed real world data of patients who underwent resuscitation transplantation between October 2019 and July 2021 at the Reproductive Center of Chengdu Jinjiang Hospital for Women’s and Children’s Health. Propensity score matching was applied to control potential confounding factors. A total of 5,549 patients who received at least one FET were analyzed. Patients undergoing transplantation within 60 days of oocyte retrieval were included in the immediate FET group (n = 1,265) and those undergoing transplantation > 60 days after retrieval were included in the delayed FET group (n = 4,284).ResultsLive birth rates between the two groups were comparable (45.25% vs. 45.76%, p = 0.757). Moreover, no difference was observed in the rates of biochemical pregnancy (64.50% vs. 66.80%), clinical pregnancy (55.24% vs. 56.83%), ectopic pregnancy (1.47% vs. 1.39%), early miscarriage (14.41% vs. 16.20%), late miscarriage (2.21% vs. 2.09%), singleton premature delivery (16.67% vs. 18.29%), and neonatal deformity (1.97% vs. 1.80%). After stratifying the patients based on the type of embryo transferred, number of embryos transferred, FET protocol, and good prognosis criteria, live birth rates remained comparable between the two groups (p > 0.05).ConclusionPregnancy outcomes were comparable between the immediate and delayed FET groups.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of interval between oocyte retrieval and resuscitation embryo transfer on pregnancy outcomes

Wan

Chen

Wang³

et al. 2023

Front. Med.

View full text Add to dashboard Cite

show abstract

“…Our study concluded that immediate FET and delayed FET showed comparable live birth rates for different embryo types, embryo numbers, and different endometrial preparation protocols, which is consistent with the ndings of other studies [6,10]. Therefore, there is no evidence to support the necessity for routine delay of at least one menstrual cycle after IVF/ICSI before FET.…”

Section: Discussionsupporting

confidence: 87%

Effect of interval between oocyte retrieval and resuscitation embryo transfer on pregnancy outcomes

Wan¹,

Chen²,

Wang³

et al. 2022

Preprint

View full text Add to dashboard Cite

Resuscitation transfer of embryos after cryopreservation is gaining popularity worldwide due to higher implantation rates. This method separates oocyte retrieval from embryo transfer. The optimal time for frozen embryo transfer (FET) remains unknown. This retrospective cohort study aimed to determine the difference in pregnancy outcomes between patients who underwent immediate FET and delayed FET. We analyzed real-world data of patients who underwent resuscitation transplantation between October 2019 and July 2021 at the Reproductive Center of Chengdu Jinjiang Hospital for Women’s and Children’s Health. Propensity score matching was applied to control for potential confounding factors. A total 5549 patients who received at least one FET were analyzed. Patients transplanted within 60 days of oocyte retrieval were included in the immediate FET group (n = 1265) and those transplanted > 60 days after retrieval were included in the delayed FET group (n = 4284). After propensity score matching, live birth rates between the two groups were comparable (45.25% vs. 45.76%, p = 0.757). Moreover, no difference was observed in the rates of biochemical pregnancy (64.50% vs. 66.80%), clinical pregnancy (55.24% vs. 56.83%), ectopic pregnancy (1.47% vs. 1.39%), early miscarriage (14.41% vs. 16.20%), late miscarriage (2.21% vs. 2.09%), singleton premature delivery (16.67% vs. 18.29%), and neonatal deformity (1.97% vs. 1.80%). After stratifying the patients based on the type of embryo transferred, number of embryos transferred, FET protocol, and good prognosis criteria, live birth rates were still comparable between the two groups after propensity score matching (p > 0.05). In conclusion, pregnancy outcomes were comparable between the immediate and delayed FET groups.

show abstract

“…Previous metaanalyses have not come to a de nitive conclusion on how immediate or delayed resuscitation bene t pregnancy rates [7,8]. Additionally, many of the retrospective studies [9][10][11] in the literature were conducted years ago, and the results of these studies may be biased against changes in the existing COH protocols.…”

Section: Introductionmentioning

confidence: 99%

Effect of interval between oocyte retrieval and resuscitation embryo transfer on pregnancy outcomes

Wan

Chen

Wang³

et al. 2022

Preprint

View full text Add to dashboard Cite

Resuscitation transfer of embryos after elective cryopreservation is gaining popularity worldwide owing to higher implantation rates. This method separates oocyte retrieval from embryo transfer. The optimal time for frozen embryo transfer (FET) remains unknown. This retrospective cohort study aimed to determine the difference in pregnancy outcomes between patients who underwent immediate FET and those who underwent delayed FET. We analyzed real-world data of patients who underwent resuscitation transplantation between October 2019 and July 2021 at the Reproductive Center of Chengdu Jinjiang Hospital for Women’s and Children’s Health. Propensity score matching was applied to control for potential confounding factors. A total of 5549 patients who received at least one FET were analyzed. Patients undergoing transplantation within 60 days of oocyte retrieval were included in the immediate FET group (n = 1265) and those undergoing transplantation > 60 days after retrieval were included in the delayed FET group (n = 4284). Live birth rates between the two groups were comparable (45.25% vs. 45.76%, p = 0.757). Moreover, no difference was observed in the rates of biochemical pregnancy (64.50% vs. 66.80%), clinical pregnancy (55.24% vs. 56.83%), ectopic pregnancy (1.47% vs. 1.39%), early miscarriage (14.41% vs. 16.20%), late miscarriage (2.21% vs. 2.09%), singleton premature delivery (16.67% vs. 18.29%), and neonatal deformity (1.97% vs. 1.80%). After stratifying the patients based on the type of embryo transferred, number of embryos transferred, FET protocol, and good prognosis criteria, live birth rates remained comparable between the two groups (p > 0.05). In conclusion, pregnancy outcomes were comparable between the immediate and delayed FET groups.

show abstract

Effect of the time for embryo transfer from oocyte retrieval on clinical outcomes in freeze-all cycles: a retrospective cohort study

Cited by 7 publications

References 31 publications

Effect of interval between oocyte retrieval and resuscitation embryo transfer on pregnancy outcomes

Effect of interval between oocyte retrieval and resuscitation embryo transfer on pregnancy outcomes

Effect of interval between oocyte retrieval and resuscitation embryo transfer on pregnancy outcomes

Effect of interval between oocyte retrieval and resuscitation embryo transfer on pregnancy outcomes

Contact Info

Product

Resources

About