Effect of the Trigeminal Nerve Stimulation on Auditory Event-Related Potentials

Fantozzi, Maria Paola Tramonti; Artoni, Fiorenzo; Galante, Marco Di; Briscese, Lucia; Cicco, Vincenzo De; Bruschini, Luca; D'Ascanio, Paola; Manzoni, Diego; Faraguna, Ugo; Carboncini, Maria Chiara

doi:10.1093/texcom/tgab012

Cited by 11 publications

(9 citation statements)

References 64 publications

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“…When multiple statistical tests were performed, a bootstrap procedure was applied as previously described [ 42 ]. As the same size as the original sample ( n = 10), a new population of participants was performed, allowing repetition.…”

Section: Methodsmentioning

confidence: 99%

Sleep Deprivation-Induced Changes in Baseline Brain Activity and Vigilant Attention Performance

et al. 2022

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Sleep deprivation (SD) negatively affects several aspects of cognitive performance, and one of the most widely-used tools to evaluate these effects is the Psychomotor Vigilance Test (PVT). The present study investigated the possibility of predicting changes induced by SD in vigilant attention performance by evaluating the baseline electroencephalographic (EEG) activity immediately preceding the PVT stimuli onset. All participants (n = 10) underwent EEG recordings during 10 min of PVT before and after a night of SD. For each participant, the root mean square (RMS) of the baseline EEG signal was evaluated for each 1 s time window, and the respective average value was computed. After SD, participants showed slower (and less accurate) performance in the PVT task. Moreover, a close relationship between the changes in the baseline activity with those in cognitive performance was identified at several electrodes (Fp2, F7, F8, P3, T6, O1, Oz, O2), with the highest predictive power at the occipital derivations. These results indicate that vigilant attention impairments induced by SD can be predicted by the pre-stimulus baseline activity changes.

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Section: Methodsmentioning

confidence: 99%

Sleep Deprivation-Induced Changes in Baseline Brain Activity and Vigilant Attention Performance

et al. 2022

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“…This indicated an increased arousal state and correlated with better functional recovery. Under healthy conditions, TNS enhances the signal-to-noise ratio of cortical neurons, allowing subjects to reach optimal discriminative performance in the oddball task at lower levels of neural activation (Tramonti Fantozzi et al 2021 ).…”

Section: Effects Of Trigeminal Nerve Stimulationmentioning

confidence: 99%

Trigeminal nerve stimulation: a current state-of-the-art review

Powell,

Lin,

Tambo

et al. 2023

Bioelectron Med

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Nearly 5 decades ago, the effect of trigeminal nerve stimulation (TNS) on cerebral blood flow was observed for the first time. This implication directly led to further investigations and TNS’ success as a therapeutic intervention. Possessing unique connections with key brain and brainstem regions, TNS has been observed to modulate cerebral vasodilation, brain metabolism, cerebral autoregulation, cerebral and systemic inflammation, and the autonomic nervous system. The unique range of effects make it a prime therapeutic modality and have led to its clinical usage in chronic conditions such as migraine, prolonged disorders of consciousness, and depression. This review aims to present a comprehensive overview of TNS research and its broader therapeutic potentialities. For the purpose of this review, PubMed and Google Scholar were searched from inception to August 28, 2023 to identify a total of 89 relevant studies, both clinical and pre-clinical. TNS harnesses the release of vasoactive neuropeptides, modulation of neurotransmission, and direct action upon the autonomic nervous system to generate a suite of powerful multitarget therapeutic effects. While TNS has been applied clinically to chronic pathological conditions, these powerful effects have recently shown great potential in a number of acute/traumatic pathologies. However, there are still key mechanistic and methodologic knowledge gaps to be solved to make TNS a viable therapeutic option in wider clinical settings. These include bimodal or paradoxical effects and mechanisms, questions regarding its safety in acute/traumatic conditions, the development of more selective stimulation methods to avoid potential maladaptive effects, and its connection to the diving reflex, a trigeminally-mediated protective endogenous reflex. The address of these questions could overcome the current limitations and allow TNS to be applied therapeutically to an innumerable number of pathologies, such that it now stands at the precipice of becoming a ground-breaking therapeutic modality.

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“…This approach seems particularly relevant since many ERP components have been operationally related to several specific neurocognitive processes [ 86 , 87 ], including attention, working memory, and decision-making [ 88 , 89 , 90 ]. Both studies used short-term TNS administration but, interestingly, one study [ 91 ] used bilateral transcutaneous stimulation of the trigeminal motor branches (over the masseter belly, incisura sigmoidea), while in the other [ 92 ], the IoN sensitive branch was bilaterally stimulated.…”

Section: How Trigeminal Nerve Stimulation May Affect Cognitive Functionmentioning

confidence: 99%

“…In the first study, Fantozzi and colleagues [ 91 ] showed in 13 healthy subjects a reduction of the amplitude of the P300 wave elicited by an acoustic oddball paradigm in several cortical areas, and a positive correlation between P300 amplitude in frontal and median cortical region and pupil size. The authors ascribed these results to increased cortical norepinephrine (NE) levels due to a TNS-augmented activity of LC neurons.…”

Section: How Trigeminal Nerve Stimulation May Affect Cognitive Functionmentioning

confidence: 99%

“…The authors ascribed these results to increased cortical norepinephrine (NE) levels due to a TNS-augmented activity of LC neurons. High cortical NE levels may improve sensory processing, suggesting that TNS could be used for improving cognitive performance in subjects with cognitive disorders or arousal dysfunction [ 91 , 93 ].…”

Section: How Trigeminal Nerve Stimulation May Affect Cognitive Functionmentioning

confidence: 99%

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Cognitive Functions following Trigeminal Neuromodulation

Mercante,

Enrico,

Deriu

2023

Biomedicines

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Vast scientific effort in recent years have been focused on the search for effective and safe treatments for cognitive decline. In this regard, non-invasive neuromodulation has gained increasing attention for its reported effectiveness in promoting the recovery of multiple cognitive domains after central nervous system damage. In this short review, we discuss the available evidence supporting a possible cognitive effect of trigeminal nerve stimulation (TNS). In particular, we ask that, while TNS has been widely and successfully used in the treatment of various neuropsychiatric conditions, as far as research in the cognitive field is concerned, where does TNS stand? The trigeminal nerve is the largest cranial nerve, conveying the sensory information from the face to the trigeminal sensory nuclei, and from there to the thalamus and up to the somatosensory cortex. On these bases, a bottom-up mechanism has been proposed, positing that TNS-induced modulation of the brainstem noradrenergic system may affect the function of the brain networks involved in cognition. Nevertheless, despite the promising theories, to date, the use of TNS for cognitive empowering and/or cognitive decline treatment has several challenges ahead of it, mainly due to little uniformity of the stimulation protocols. However, as the field continues to grow, standardization of practice will allow for data comparisons across studies, leading to optimized protocols targeting specific brain circuitries, which may, in turn, influence cognition in a designed manner.

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Effect of the Trigeminal Nerve Stimulation on Auditory Event-Related Potentials

Cited by 11 publications

References 64 publications

Sleep Deprivation-Induced Changes in Baseline Brain Activity and Vigilant Attention Performance

Sleep Deprivation-Induced Changes in Baseline Brain Activity and Vigilant Attention Performance

Trigeminal nerve stimulation: a current state-of-the-art review

Cognitive Functions following Trigeminal Neuromodulation

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