The rock saturation condition affects the rock elastic and strength characteristics due to the role of fluid−rock interaction. However, the role of this parameter has not been studied well for mud−rock exposure during drilling operations. Hence, this study targets to assess the role of different rock saturation conditions on the rock geomechanics changes during the rock exposure for the drilling fluids. During the drilling operation, the mud filtrate invades the drilled formation pore system and replaces the saturating fluid and consequent alterations occur for the rock elastic moduli and failure properties. The current study employed Berea Buff sandstone rock type with different saturation conditions (brine-saturated, dry, and oil-saturated) to interact with drilling mud (water-based) through the filtration test to mimic the downhole rock−mud exposure under pressure, temperature, and time conditions. Extensive laboratory analysis was accomplished that covered the scratching test to get the strength of rock samples, acoustic data determination, elastic moduli evaluation, and scanning electron microscopy to assess the internal alterations of the rock pore system. The obtained results showed that the oil-saturated sample showed the least filtration characteristics for the rock−mud exposure and the best condition to maintain the rock strength from deterioration compared to the dry and brine-saturated samples. The rock strength showed a weakening behavior for the brinesaturated and dry samples by 5 and 18% respectively, while the oil-saturated sample showed only a 2% strength reduction after the mud exposure. Poisson's ratio showed a 21% increase for the brine-saturated sample and the dry sample showed a small increase from 0.2 to 0.22, while the oil-saturated sample maintains a stable Poisson's ratio at 0.24. Young's modulus showed an increase for the dry and brine-saturated rock samples by 10 and 7%, respectively, while a 25% reduction for the oil-saturated. The spectrometry analysis results showed the internal changes in the rock samples' pore system for the brine-saturated and dry samples, while the oilsaturated sample showed no internal changes that maintain the rock structure and strength after the mud exposure.