Effect of the type of dietary fat on biliary lipid composition and bile lithogenicity in humans with cholesterol gallstone disease

Yago, M. D.; González, Victoria; Serrano, Pilar; Calpena, Rafael; Martínez, M.a C. López; Martínez-Victoria, Emilio; Mañas, Mariano

doi:10.1016/j.nut.2004.06.028

Cited by 27 publications

(15 citation statements)

References 32 publications

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“…Cholesterol gallstone disease is a common disease in western countries and also in Japan. A number of dietary factors are involved in the pathogenesis of cholesterol cholelithiasis [34,35]. It has been reported that populations consuming a diet rich in n-3 FUPA exhibit a low incidence of cholesterol cholelithiasis [36].…”

Section: Discussionmentioning

confidence: 99%

Fatty Acid Composition of Plasma, Erythrocytes and Adipose: Their Correlations and Effects of Age and Sex

Ogura

Takada

Okuno

et al. 2010

Lipids

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The composition of fatty acids in abdominal subcutaneous adipose tissue and the correlation of fatty acid values of plasma and erythrocytes had not been reported in Japan. The aim of the present study was to investigate the fatty acid composition and correlation of plasma and erythrocyte phospholipids (PL) and adipose triacylglycerols (TG) in 75 adult patients admitted for non-malignant diseases. We also examined the relationship of n-3 and n-6 polyunsaturated fatty acid (PUFA) with patients' characteristics. The total n-3 PUFA were 11.2, 11.8 and 1.9%, and the ratios of n-6/n-3 were 2.41, 1.87 and 8.20 in plasma and erythrocyte PL and adipose TG, respectively. There were the highest correlations for total n-3 PUFA and the n-6/n-3 ratio between plasma and erythrocyte PL and adipose TG. There was a positive correlation between n-3 PUFAs and age, but a negative correlation was found between n-6 PUFAs and age. There was no significant difference in the values of PUFAs in plasma and erythrocyte PL and adipose TG between men and women. The patients with cholesterol cholecystolithiasis showed a significantly lower proportion of eicosapentaenoic acid in plasma and erythrocyte PL than those of the other patients. Our findings suggest that PUFA in plasma and erythrocyte PL may be good biomarkers and more acceptable for studying participants than adipose TG.

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Section: Discussionmentioning

confidence: 99%

Fatty Acid Composition of Plasma, Erythrocytes and Adipose: Their Correlations and Effects of Age and Sex

Ogura

Takada

Okuno

et al. 2010

Lipids

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“…The fine structure [21,25], bacterial colonization [26] and mechanistics of gallstone generation [27-30] have been studied in detail in previous experiments. We think, that this study still makes a substantial contribution in that it has focussed more on a general epidemiological survey of gallstone composition mainly to determine the principal components of the current gallstones in order to help identify patients for future innovative non-surgical interventions [12]: In the descriptive statistics of gallstone composition, two main conclusions can be drawn: Firstly, gallstones in the investigated population are quite homogenous in terms of their main components: In only eightytwo (7.6%, including sixty stones, that contained bilirubin/cholesterol combinations) out of 1074 stones, different main substances were identified in the two samples taken from each stone (Table 3).…”

Section: Discussionmentioning

confidence: 99%

Predictors of gallstone composition in 1025 symptomatic gallstones from Northern Germany

Schafmayer

Hartleb²,

Tepel

et al. 2006

BMC Gastroenterol

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Background: Gallstones represent a prevalent and costly health problem. The changing epidemiology and the emerging non-surgical interventions for gallstone disease necessitate the definition of target populations for future therapies. This study aimed to define patterns of gallstone composition and identify demographic predictors of gallstone composition in a large sample of symptomatic gallstones from Northern Germany.

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“…As noted in Table 129.4, intake of VOO or SO diets for 30 days before cholecystectomy did not affect the cholesterol saturation index (CSI) in gallbladder bile (Yago et al, 2005), a somehow expected finding considering the presence of established gallstones in the gallbladder. However, when gallbladder bile composition was expressed in terms of absolute concentrations of lipids, the concentration of cholesterol and total bile acids (BA) was shown to be significantly diminished in SO subjects.…”

Section: Biliary Lipid Composition and Bile Lithogenicitymentioning

confidence: 77%

Influence of Olive Oil on Pancreatic, Biliary and Gastric Secretion

Yago¹,

Audi²,

Mañas³

et al. 2010

Olives and Olive Oil in Health and Disease Prevention

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Effect of the type of dietary fat on biliary lipid composition and bile lithogenicity in humans with cholesterol gallstone disease

Cited by 27 publications

References 32 publications

Fatty Acid Composition of Plasma, Erythrocytes and Adipose: Their Correlations and Effects of Age and Sex

Fatty Acid Composition of Plasma, Erythrocytes and Adipose: Their Correlations and Effects of Age and Sex

Predictors of gallstone composition in 1025 symptomatic gallstones from Northern Germany

Influence of Olive Oil on Pancreatic, Biliary and Gastric Secretion

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