Effect of the Use and Timing of Bone Marrow Mononuclear Cell Delivery on Left Ventricular Function After Acute Myocardial Infarction

Cardiac Repair Using Stem Cells Conditioned Media Based Therapy in a Rodent Model of Myocardial Infarction and Heart Failure

“…human and animal models, to varying degrees of success [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] . In animal models, these cellbased therapies have demonstrated effectiveness in reducing infarct size and ventricular dilatation, and improving myocardial function [24][25][26] .…”

Estado actual de la terapia con células madre en el tratamiento de las cardiopatías: An update

“…El SWISS-AMI (n = 192) pretendía determinar si existían diferencias entre la infusión intracoronaria temprana (5-7 días) versus tardía (3-4 semanas) de BMMC en pacientes post IAM sometidos a terapia de reperfusión 61 . Por otra parte, el estudio TIME (n = 120) evaluó el impacto sobre la función ventricular de la administración de BMMC al tercer y séptimo día post angioplastía, en pacientes post IAM 62 . Estos estudios no reportaron con este tipo celular, diferencias entre el tratamiento precoz y tardío, sobre la función ventricular.…”

Stem Cell Therapy for Heart Disease

“…52 REPAIR-AMI and TOP-CARE-AMI confirmed that patients with decreased baseline EF showed more improvement. 44,45,51,52 Some trials did not show significant results, 57,60,[63][64][65] while others demonstrated some benefits without EF changes. 43,53,54,62 Heart Failure Additionally, there have been multiple HF trials (Table 2).…”

“…63 Results showed no significant recovery benefit on ventricular function in either timing group. 64 SWISS-AMI assessed BMC delivery at 1 week versus 3-4 weeks after AMI.…”