Effect of the Use of Gnrh Analogs in Low-Grade Cerebral Glioma

Abstract

Low-grade gliomas are the most common brain tumors in children. This tumor type presents a wide range of clinical, histological, and biological behaviors. In recent years, an association between estrogens and progesterone and the development of tumors has been suggested. A case of a 2-year-old girl is described with a low-grade brain tumor treated with chemotherapy and disease stabilization. The treatment with Decapeptyl® was initiated due to precocious puberty, and the tumor showed a decrease in its solid component—more than 50% of the initial size—three years after starting treatment. Several studies have described the influence of estrogen and progesterone on the development of gliomas, decreasing or increasing their expression in those tumors with greater aggressiveness, respectively. Despite the fact that the tumor-hormonal expression relationship in other tumor types has been evaluated, its role in the treatment of brain tumors remains unknown.

Optic Pathway Gliomas in Pediatric Population—Current Approach in Diagnosis and Management: Literature Review

“…Laboratory investigations should include tumor markers (AFP and B-HCG) for suprasellar lesions detected on imaging to exclude germ cell tumors [77,78]. Currently, with the use of molecular diagnosis employing Next-Generation Sequencing (NGS) methods, we can identify known mutations within the BRAF and NF1 genes.…”