Effect of theophylline on gastroesophageal reflux in normal adults

Berquist, William E.; Rachelefsky, Gary S.; Kadden, Mark; Siegel, Sheldon C.; Katz, Roger M.; Mickey, M. R.; Ament, Marvin E.

doi:10.1016/0091-6749(81)90087-7

Cited by 111 publications

(35 citation statements)

References 8 publications

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“…In a randomized, double-blind, placebo-controlled study investigating the effects of theophylline on GERD in normal adults, theophylline and a pla-cebo were compared at a single oral treatment dose (by performing manometry and measuring pH at the basal, 1.5 th , 4 th , and 8 th h). It was shown that theophylline induced GERD by reducing LESP (100% vs. 22%) in all patients compared to the placebo, increased the frequency of reflux compared to the placebo (73% vs. 11%), and led to new reflux symptoms in 61.5% of cases (37). In a randomized, double-blind, cross-comparative study by Hubert et al (38), 16 patients with asthma (none of whom received oral steroids or anticholinergic drugs and all of whom were stabilized with an inhaled b2 agonist) were given theophylline or a placebo in hospital at one-week intervals.…”

Section: Anticholinergic Drugsmentioning

confidence: 99%

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Which drugs are risk factors for the development of gastroesophageal reflux disease?

Mungan

Simsek

2020

Turk J Gastroenterol

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Section: Anticholinergic Drugsmentioning

confidence: 99%

“…Antiasthmatic drugs, particularly methylxanthines, are known to cause the development of reflux in asthmatic patients and normal healthy volunteers (36,37). Aminophyllines increase gastric acid secretion and reduce LESP.…”

Section: Anticholinergic Drugsmentioning

confidence: 99%

Which drugs are risk factors for the development of gastroesophageal reflux disease?

Mungan

Simsek

2020

Turk J Gastroenterol

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“…Tachykinin-mediated neurogenic inflammation has been suggested as a mechanism in the development of a response to inhaled irritants and is potentially important in patients with asthma [Barnes, 2001]. Paradoxically, treatments for asthma may also worsen reflux, with theophyllines [Berquist et al 1981 …”

Section: Asthmamentioning

confidence: 99%

Airway reflux, cough and respiratory disease

Molyneux

Morice

2011

Therapeutic Advances in Chronic Disease

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It is increasingly accepted that the effects of gastro-oesophageal reflux are not limited to the gastrointestinal tract. The adjacent respiratory structures are also at risk from material ejected from the proximal oesophagus as a result of the failure of anatomical and physiological barriers. There is evidence of the influence of reflux on several respiratory and otorhinological conditions and although in many cases the precise mechanism has yet to be elucidated, the association alone opens potential novel avenues of therapy to clinicians struggling to treat patients with apparently intractable respiratory complaints. This review provides a description of the airway reflux syndrome, its effects on the lung and current and future therapeutic options.

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“…Therapeutic doses of beta agonists, however, do not increase GER in asthma patients or normal subjects (23,24 half of investigators have reported that theophylline increases GER, but the remainder were unable to demonstrate an effect (25)(26)(27)(28)(29)(30). Two groups did not find an increased prevalence of GER in asthma patients receiving regular bronchodilator medication (13,14).…”

Section: Do Bronchodilators Cause Ger?mentioning

confidence: 73%

Gastroesophageal Reflux and Asthma: Can the Paradox Be Explained?

Field¹

2000

Canadian Respiratory Journal

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BACKGROUND AND OBJECTIVE:The reported effects of asthma on gastroesophageal reflux (GER), effects of GER on asthma and the effects of antireflux therapy on asthma are conflicting. The purpose of this paper is to review the evidence for a relationship between the two conditions.DESIGN:A search of the MEDLINE 1966 to 1999 database, combining the terms GER and asthma, was used to identify studies of the effects of acid perfusion of the esophagus, the physiological equivalent of GER and the effects of both medical and surgical antireflux therapy on asthma. Bibliographies of the identified papers were also reviewed.MAIN RESULTS:The collected evidence suggests that GER causes asthma symptoms but has minimal effects on pulmonary function. Both medical and surgical antireflux therapy can improve asthma symptoms and asthma medication requirements without improving pulmonary function. The paradox of GER causing symptoms without affecting pulmonary function may be because of the retrosternal discomfort that accompanies GER increases minute ventilation and respiratory sensation.CONCLUSIONS:Despite an extensive body of literature, many questions remain about the relationship between GER and asthma. A review of the data suggests a strong association between the two conditions, and that GER worsens asthma symptoms without affecting pulmonary function. Asymptomatic GER does not worsen asthma. Antireflux therapy may have a role in asthma patients with symptomatic GER, possibly being most beneficial for those with reflux-associated respiratory symptoms. Unfortunately, many studies contain flaws such as a lack of controls and small sample sizes. Further properly designed controlled trials, including ones that measure the effects of GER and antireflux therapy on quality of life, are needed to understand better the role of GER in asthma.

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Effect of theophylline on gastroesophageal reflux in normal adults

Cited by 111 publications

References 8 publications

Which drugs are risk factors for the development of gastroesophageal reflux disease?

Which drugs are risk factors for the development of gastroesophageal reflux disease?

Airway reflux, cough and respiratory disease

Gastroesophageal Reflux and Asthma: Can the Paradox Be Explained?

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