Effect of therapeutic concentrations of nitric oxide on bacterial growth in vitro

Abstract

We conclude that NO has a selective bacteriostatic effect on some of those bacteria most commonly cultured in tracheal specimens of premature infants and neonates. This effect appears to be dose-dependent and occurs in the upper range of dosages used with inhaled NO therapy. However, in the range of dosages applied in ongoing controlled trials of inhaled NO in neonates and premature infants (1 to 80 ppm), a bacteriostatic effect of NO is not to be expected.

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

“…Die respiratorische Schleimhaut der Nase besitzt eine hohe Enzymaktivit ä t, vor allem des Cytochrom P-450-Systems [34] . NO, das vor allem durch die Schleimhaut der Nasennebenh ö hlen produziert und in das Lumen freigesetzt wird, soll eine bakterizide Wirkung im Bereich der gesamten Atemwege aus ü ben [35] .…”

Antibacterial and bactericidal activity of nitric oxide-releasing natural zeolite

“…It was stated that nitrite (NO 2 − ), a stable end product of NO oxidation, can be toxic to cells (Menzel, 1993). The formation of NO 2 − is dependent on the concentration of the reactants (NO and O 2 ) as well as the time available for the reaction (Hoehn et al, 1998). The major oxidation reactions of NO by O 2 in an aqueous solution are shown below (Wang and Deen, 2003):…”

Glutamine Is Essential for Nitric Oxide Synthesis by Murine Macrophages

“…These enzymes avidly consume the amino acid L-arginine. The enzyme iNOS utilizes arginine, as substrate, to generate large amounts of NO, which, in turn, inhibit the growth of bacteria [5][6][7][8]. The enzyme arginase converts arginine directly to L-ornithine and urea [9], thus reducing the availability of arginine to iNOS.…”