Effect of Therapeutic Pulsed Ultrasound on Lipoperoxidation and Fibrogenesis in an Animal Model of Wound Healing

Freitas, Tiago P.; Gomes, Marcelo Gomes de; Fraga, Daiane B.; Freitas, Luciana S.; Rezin, Gislaine T.; Santos, P.M.L.; Paula, Marcos Marques da Silva; Pinho, Ricardo A.; Streck, Emílio L.

doi:10.1016/j.jss.2009.04.002

Cited by 21 publications

(20 citation statements)

References 30 publications

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“…Colloidal gold and some of the compounds have recognized therapeutic properties, especially for the treatment of inflammatory and arthritic processes (Kim et al, 2007). Several studies performed in our group using phonophoresis and/or iontophoresis with topic application of GNP for treating muscle and tendon injuries in rats show promise and indicate the possibility of use this new therapy in the treatment of these diseases in humans (Freitas et al, 2007(Freitas et al, , 2010Silveira et al, 2010Silveira et al, , 2012Dohnert et al, 2012;Engelmann et al, 2012;Victor et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…The movement of the beam was circular. The parameters used for the TPU were established in previous studies by our group (Freitas et al, 2007(Freitas et al, , 2010Silveira et al, 2010). The groups with muscle injury and treatment with DMSO, GNPs and Plus were also exposed to circular beam movement for 6 min with the ultrasound in off mode (Saliba et al, 2007).…”

Section: Treatmentmentioning

confidence: 99%

“…TPU is a noninvasive form of mechanical energy transmitted transcutaneously as high-frequency acoustic pressure waves into biological tissues (Lu et al, 2009). The beneficial effects of TPU on a variety of connective tissues and related cellular and molecular mechanisms have been assessed biomechanically (Piedade et al, 2008;Alfredo et al, 2009;Freitas et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Ours results have shown that 5 and 7 days after the muscle injury the anti-inflammatory and antioxidants effects are potentiated from application of nanoparticles plus ultrasound. (Freitas et al, 2007(Freitas et al, , 2010Engelmann et al, 2012;Silveira et al, 2010Silveira et al, , 2012Victor et al, 2012). Therefore, considering such results, we decided to evaluate the effects of this therapy on oxidative stress parameters at an earlier stage of the inflammatory response (48 h), when the production of ROS is greater.…”

Section: Introductionmentioning

confidence: 99%

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Effects of phonophoresis with gold nanoparticles on oxidative stress parameters in a traumatic muscle injury model

et al. 2014

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The aim of this study was to evaluate the effects of therapeutic pulsed ultrasound with gold nanoparticles on oxidative stress parameters after traumatic muscle injury in Wistar rats. The animals were randomly divided into nine groups (n ¼ 6 each): sham (uninjured muscle); muscle injury without treatment; muscle injury and treatment with dimethyl sulfoxide (15 mg/kg); muscle injury and treatment with gold nanoparticles (27 mg); muscle injury and treatment with dimethyl sulfoxide + gold nanoparticles (Plus); muscle injury and therapeutic pulsed ultrasound; muscle injury and therapeutic pulsed ultrasound + dimethyl sulfoxide; muscle injury and therapeutic pulsed ultrasound + gold nanoparticles; and muscle injury and therapeutic pulsed ultrasound + Plus. Gastrocnemius injury was induced by a single-impact blunt trauma. Therapeutic pulsed ultrasound (6-min application, frequency 1.0 MHz, intensity 0.8 W/cm 2 ) was used 2, 12, 24, and 48 h after trauma. Mitochondrial superoxide generation, lipid peroxidation, and protein carbonylation, and the activities of superoxide dismutase, glutathione peroxidase, and catalase were evaluated. The increase in the superoxide production and TBARS and carbonyl levels observed in the control group after muscle damage were reduced in animals exposed to therapeutic pulsed ultrasound plus nanoparticles. Similarly, antioxidants enzymes showed a decreased activity with the same treatment. Our work suggest that therapeutic pulsed ultrasound + dimethyl sulfoxide + gold nanoparticles has beneficial effects on the muscle healing process by inducing a decrease in oxidative stress parameters and most likely decreasing the deleterious effects of the inflammatory response.

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Section: Discussionmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of phonophoresis with gold nanoparticles on oxidative stress parameters in a traumatic muscle injury model

et al. 2014

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“…16,24,25 Several of the studies showing significant support for US application, particularly in the area of enhancing repair of soft tissue following injury, have been laboratory (i.e., cellular or animal) studies with questionable relevance to humans. [26][27][28][29][30][31][32] The discrepancy in results between experimental and clinical studies warrants further research to clarify the therapeutic effectiveness of US in clinical practice. The limited clinical evidence also raises questions about why US is commonly used in clinical practice.…”

mentioning

confidence: 99%

Usage Patterns and Beliefs about Therapeutic Ultrasound by Canadian Physical Therapists: An Exploratory Population-Based Cross-Sectional Survey

Armijo‐Olivo

Fuentes

Muir

et al. 2013

Physiotherapy Canada

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Purpose: To explore the frequency and patterns of ultrasound (US) usage among physical therapists, to describe the most common purposes for using therapeutic US, and to investigate beliefs about therapeutic US. Methods: A survey was sent to 95% of physical therapists licensed to practise in the province of Alberta, Canada. Results: Of 2,269 physical therapists to whom email invitations were sent, 438 (19.3%) provided full responses. Results indicate that US is still frequently incorporated into treatment regimens and is widely believed to be effective; however, the study also found a decrease in US usage over the past 15 years. While physical therapists recognize the lack of evidence for the effectiveness of US, many consider it clinically useful. Physical therapists using US rely largely on their clinical experience when making decisions about its use, but this depends on level of education: clinicians with an MScPT degree tended to base more of their US decisions on research evidence, likely because of the increasing emphasis on research evidence in graduate education. Conclusions: Despite the questionable effectiveness of therapeutic US, physical therapists still commonly use this treatment modality, largely because of a belief that US is clinically useful. However, US usage has decreased over the past 15 years.Key Words: ultrasonic therapy; surveys, beliefs. RÉ SUMÉObjectif : Explorer la fré quence et les tendances de l'utilisation de l'é chographie chez les physiothé rapeutes, dé crire les raisons thé rapeutiques les plus courantes d'utiliser l'é chographie thé rapeutique et analyser les croyances relatives à l'é chographie thé rapeutique. Mé thodes : On a envoyé un questionnaire à 95% des PT autorisé s à pratiquer en Alberta, au Canada. Ré sultats : Sur 2 269 physiothé rapeutes qui ont é té invité s par courriel, 438 (19,3%) ont ré pondu au questionnaire au complet. Les ré sultats indiquent que l'é chographie fait toujours partie fré quemment des protocoles de traitement et que l'on croit gé né ralement qu'elle est efficace. L'é tude a toutefois ré vé lé aussi une baisse de l'utilisation de l'é chographie au cours des 15 derniè res anné es. Les physiothé rapeutes reconnaissent peut-ê tre le manque de donné es probantes sur l'efficacité de l'é chographie, mais beaucoup d'entre eux la jugent utile sur le plan clinique. Les physiothé rapeutes qui utilisent l'é chographie s'en remettent en grande partie à leur expé rience clinique lorsqu'ils prennent une dé cision sur son utilisation, mais tout dé pend du niveau d'é ducation: les cliniciens qui ont une maîtrise en physiothé rapie ont tendance à fonder davantage leur dé cision d'y recourir sur des donné es de recherche, probablement parce qu'on accorde de plus en plus d'importance aux donné es de recherche au cours des é tudes supé rieures. Conclusions : En dé pit de l'efficacité douteuse de l'é chographie thé rapeutique, les physiothé rapeutes utilisent encore couramment ce mode de traitement, surtout parce que l'on croit qu'elle utile sur le plan clin...

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Modalities Part 4

Medina¹,

Davies

2017

Physical Rehabilitation for Veterinary Technicians and Nurses

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Effect of Therapeutic Pulsed Ultrasound on Lipoperoxidation and Fibrogenesis in an Animal Model of Wound Healing

Cited by 21 publications

References 30 publications

Effects of phonophoresis with gold nanoparticles on oxidative stress parameters in a traumatic muscle injury model

Effects of phonophoresis with gold nanoparticles on oxidative stress parameters in a traumatic muscle injury model

Usage Patterns and Beliefs about Therapeutic Ultrasound by Canadian Physical Therapists: An Exploratory Population-Based Cross-Sectional Survey

Modalities Part 4

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