Effect of Therapeutic Ultrasound on Folliculogenesis, Angiogenesis and Apoptosis After Heterotopic Mouse Ovarian Transplantation

Abtahi, Naeimeh Sadat; Eimani, Hussein; Dizaj, Ahmad Vosough; Shahverdi, Abdolhossein; Fathi, Rouhollah; Hayati, Nur; Nasiri, Nahid

doi:10.1016/j.ultrasmedbio.2014.02.006

Cited by 16 publications

(16 citation statements)

References 34 publications

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“…Female Naval Medical Research Institute (NMRI) mice (4-5 weeks) were purchased from Pasteur Institute (Tehran, Iran), and kept in the animal house of Arak University under light and temperature controlled conditions in light-dark cycles for 12 h at 21 ± 2°C with free access to enough food and water. We used the NMRI mice because other studies have also shown that NMRI mice are suitable for ovarian tissue transplantation (Abedi et al, 2014;Abtahi et al, 2014;Eimani et al, 2009Eimani et al, , 2011. Mice were randomly divided into three groups (six animals per group): control (mice without ovariectomy or grafting); autograft plus saline; and autograft plus NAC (treated with 150 mg/kg intraperitoneal NAC).…”

Section: Animalsmentioning

confidence: 99%

“…A series of tissue sections were also incubated in the reaction buffer without TdT as a negative control. As a positive control, a set of sections of mice thymus gland was used (Abtahi et al, 2014). Thymus was chosen as the positive control owing to the high frequency and distribution of apoptotic cells in lymphoid tissues such as thymus.…”

Section: Terminal Deoxynucleotidyl Transferase-mediated Dutp Nick-endmentioning

confidence: 99%

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N-acetylcysteine improves function and follicular survival in mice ovarian grafts through inhibition of oxidative stress

Mahmoodi

Mehranjani

Shariatzadeh

et al. 2015

Reproductive BioMedicine Online

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The effect of N-acetylcysteine (NAC) on mouse ovary heterotopic autotransplantation was investigated. Mice (age 4-5 weeks) were divided into the following groups: control; autograft plus NAC (150 mg/kg daily intraperitoneal injection) and autograft plus saline (n = 6 per group). Groups were treated from 1 day before until 7 days after transplantation. After 28 days, ovary compartments were estimated stereologically. Plasma malondialdehyde, progesterone, oestradiol concentrations and the percentage of apoptotic follicles were measured to evaluate the rate of oxidative stress and ovarian graft function. The mean total volume of ovary, cortex and the number of follicles was significantly higher (all P < 0.001) in the autografts plus NAC group compared with the saline group. In the autografts plus NAC group, the mean percentage of apoptotic follicles (P < 0.001) and malondialdehyde concentration (P < 0.001 day 7; P < 0.05 day 28) were significantly lower, whereas oestradiol concentration was significantly higher (P < 0.05) compared with the saline group. Although NAC cannot compensate the above parameters to the control level, it considerably improves follicular survival and development and also the structure and function of transplanted ovaries, through reducing oxidative stress and apoptosis.

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Section: Animalsmentioning

confidence: 99%

Section: Terminal Deoxynucleotidyl Transferase-mediated Dutp Nick-endmentioning

confidence: 99%

N-acetylcysteine improves function and follicular survival in mice ovarian grafts through inhibition of oxidative stress

Mahmoodi

Mehranjani

Shariatzadeh

et al. 2015

Reproductive BioMedicine Online

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“…This may be due to the ability in promoting tissue recovery and healing of low-intensity ultrasound [25]. As several studies mentioned, the low-intensity ultrasound could promote angiogenesis and cell proliferation, accelerate the collagen synthesis, and resist inflammation [27, 28], although the ultrasound alone treatment had no difference compared with control 3 group after 10 days of treatment in our research. A significant effect may be obtained after a longer treatment time, more than 10 days.…”

Section: Discussionmentioning

confidence: 58%

Low-Intensity Ultrasound Combined with Hematoporphyrin Monomethyl Ether in the Treatment of Experimental Periodontitis in Rats

Zhuang

et al. 2016

BioMed Research International

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Objectives. This study aims to evaluate the efficacy of hematoporphyrin monomethyl ether- (HMME-) mediated sonodynamic therapy (SDT) on experimental periodontal disease in rats. Methods. Periodontal disease was induced by submerging ligatures at the first maxillary molar subgingival region in forty-eight male SD rats. After 30 days, the ligatures were removed. The rats were randomly allocated into four groups; the experimental SDT group was treated through hypodermic injection of 40 μg/mL HMME and 3 W/cm2 low-intensity ultrasound irradiation (1 MHz, 600 s). Those in control groups received 40 μg/mL HMME alone (control 1 group) or 3 W/cm2 ultrasound irradiation alone (control 2 group) or were subjected to neither HMME nor ultrasound (control 3 group). After 10 days of treatment, all rats were euthanized, the maxilla was obtained for histological examination, and the alveolar bone level was evaluated by histometric analysis. Results. The control groups showed more bone loss (P < 0.05) after 10 days of treatment than the SDT group. There is no significant difference among the control groups (P > 0.05). Conclusions. HMME mediated SDT was an effective therapy of experimental periodontal tissue in rats.

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“…Topics such as dosimetry, transducer selection, duration, and safety for observing the physiological effects of therapeutic US have been the subject of various in vivo animal and in vitro artificial models [11,12]. Usually US thermal therapy appears to be disadvantaged over bones, but with appropriate application techniques, planar US can provide the required heat levels in the soft tissue under the bone in areas such as neck, shoulder, and head [13,14].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of ultrasonic heating and exercise heating on muscles by ultrasound elastography: An experimental clinical trial

Demirel¹,

Baykara²,

Koca³

et al. 2018

Journal of Surgery and Medicine

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How to cite / Atıf için: Demirel A, Baykara M, Koca TT, Berk E. Evaluation of the effect of ultrasonic heating and exercise heating on muscles by ultrasound elastography: An experimental clinical trial.This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND 4.0) where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. AbstractAim: Ultrasound (US) has been used for therapeutic purposes for many years due to its biological beneficial effects. İn this report we compare the effect of therapeutic ultrasonic heating with exercise-heating on the gastrocnemius / soleus muscles by quantitative measurements of ultrasound elastography. Methods: İt is designed as a single blind experimental clinical study. Fourty (40) healthy male patients aged between 19-23 years were included randomly in the study. To the first group, we applied a continuous wave therapeutic US on both calfs (symmetrically) consisting gastrocnemius / soleus muscle groups at a frequency of 3 Mhz, 2 w / cm 2 dose, for 6 minutes. To the second group, we applied a 15-minute jogging exercise program. Bilateral, symmetric measurements were made in the first 5 minutes with a wide band linear probe, US elastography before and after application.Results: A statistically significant decrease in ultrasound elastography strain value (UESV) after therapeutic US in gastrocnemius / soleus muscle groups was observed (p < 0.001 / p < 0.001). There was no statistically significant change in UESV in the gastrocnemius / soleus muscle groups in the jogging group (p = 0.792 / p =0.187). When the percentages of ultrasound elastography strain ratio (UESR) were examined, there was a significant difference in the change of percentages in the gastrocnemius / soleus muscle groups in both groups (p = 0.005/ p = 0.001). According to this, in both muscle groups, the elasticity increased and the stiffness decreased in group 1 and in group 2, the stiffness increased in some cases and decreased in some, and in overall it was observed to increase. Conclusion: Therapeutic US-heating is an effective, reliable method that generally increases elasticity and reduces stiffness in calf muscles than exercise-heating.

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Effect of Therapeutic Ultrasound on Folliculogenesis, Angiogenesis and Apoptosis After Heterotopic Mouse Ovarian Transplantation

Cited by 16 publications

References 34 publications

N-acetylcysteine improves function and follicular survival in mice ovarian grafts through inhibition of oxidative stress

N-acetylcysteine improves function and follicular survival in mice ovarian grafts through inhibition of oxidative stress

Low-Intensity Ultrasound Combined with Hematoporphyrin Monomethyl Ether in the Treatment of Experimental Periodontitis in Rats

Evaluation of the effect of ultrasonic heating and exercise heating on muscles by ultrasound elastography: An experimental clinical trial

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