Effect of thermal and chemical modifications on the mechanical and release properties of paracetamol tablet formulations containing corn, cassava and sweet potato starches as filler-binders

Abstract

A B S T R A C TObjective: To investigate the effects of acetylation and pregelatinization of cassava and sweet potato starches on the mechanical and release properties of directly compressed paracetamol tablet formulations in comparison with official corn starch. Methods: The native starches were modified by acetylation and pregelatinization. The tablets were assessed using friability (F r ), crushing strength (C s ), disintegration time (D t ) and dissolution parameters. Results: Starch acetylation produced paracetamol tablets that were stronger and had the best balance of mechanical and disintegration properties, while pregelatinization produced tablets that were more friable but had a better overall strength in relation to disintegration than formulations made from natural starches. Correlations mainly existed between D t and the dissolution parameters t 80 , t 2 and k 1 in the formulations. Conclusions: Modification of the experimental starches improved the mechanical and release properties of directly compressed paracetamol tablet formulations. Thus, they can be developed for use as pharmaceutical excipients in specific formulations.

Modified Starches as Direct Compression Excipients – Effect of Physical and Chemical Modifications on Tablet Properties: A Review

“…As a way to solving these problems, native starch can be readily transformed by applying certain methods to alter its properties. Modification is designed to enhance the functionality of starches as excipients for pharmaceutical use …”

“…The interest in DC technique draws from its simplicity (very few processing steps), cost‐effectiveness (few materials used), and suitability for materials sensitive to moisture . Direct compression formulation also produces consistent dissolution profiles in tablets . Table shows the processing steps involved in direct compression in comparison with dry and wet granulation methods of tablet manufacture.…”

Native and microwave-modified Terminalia mantaly gums as sustained-release and bioadhesive excipients in naproxen matrix tablet formulations

“…Disintegration time is usually a necessary step for dissolution, and it could be the rate-determining step in the process of drug absorption. 25 This is because a drug entity must be present in solution before it can be absorbed, and this requires an initial disintegration process. HPMC, the longest bioadhesion time occurred with tablet F2.…”

Characterization of Chrysophyllum albidum and Anacardium occidentale gums as wet and dry binders in ciprofloxacin tablets

“…Binder efficiency measures the interaction between tablet hardness, friability and disintegration time. A high binder efficiency implies that tablets formulated with it possess excellent hardness, low friability (<< 1%) and short disintegration time (35,36).…”