Aim: This study was carried out to evaluate the effect of mechanical fatigue and chemical aging protocols on color stability and translucency of two dental resin composite materials. Method: Twenty disc-shaped specimens were prepared from two types of dental resin composite material; nanohybrid (FiltekTm Z250 XT) and nanofilled (FiltekTm Z350 XT). The 20 specimens were further equally divided into two groups according to aging procedure. Mechanically aged and chemically aged nano hybrid groups were designated with Gp 1A and Gp 2A, respectively. While those of nano filled specimens were designated with Gp 1B and Gp 2B for the same aging treatments, respectively. Baseline readings for color and translucency were recorded before any aging treatment using Reflective spectrophotometer. For mechanical fatigue, the specimens were subjected to 6000 cyclic loading at 23.5 N using chewing simulator, while chemical aging was done by storing the specimens in acidic storage media at pH of 3.6 for 8 days. Using Reflective spectrophotometer, the change in color (Δ E) was measured and the color differences on a standard black and white backgrounds were used to calculate the translucency parameter (Δ TP). Results: After mechanical fatigue aging protocol, The change in color (Δ E) of Gp 1B was significantly higher than of Gp 1A, while chemical aging protocol resulted in insignificant difference in Δ E of Gps 2A &2B. Regarding change in translucency (Δ TP), there was a significant increase in translucency after both aging protocols. Translucency of mechanically