EFFECT OF THIOURACIL ON THE IODINE CONTENT OF THE THYROID GLAND<sup>1</sup>

Astwood, E. B.; Bissell, Adele

doi:10.1210/endo-34-4-282

Cited by 94 publications

(18 citation statements)

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“…Astwood and Bissell (17) noted that increase in the weight of thyroid in rats treated with 10 mg of TSH twice daily for 4 days was unaffected by thiouracil, and our findings that PTU did not affect the enlargement of the thyroid in iodine-depleted rats are in agreement with theirs. Albert et al (11), on the contrary, found that thiouracil potentiated the effects of 400 ug of TSH in chicks fed the goitrogen, and Alexander and Wolff (18)observed that 10 U of TSH daily for 14 days produced somewhat larger thyroid glands in rats which were also receiving propylthiouracil.…”

Section: Methodssupporting

confidence: 92%

“…The question of whether propylthiouracil potentiates the goitrogenic effects of thyrotropin has received divergent answers (11,17,18). Astwood and Bissell (17) noted that increase in the weight of thyroid in rats treated with 10 mg of TSH twice daily for 4 days was unaffected by thiouracil, and our findings that PTU did not affect the enlargement of the thyroid in iodine-depleted rats are in agreement with theirs.…”

Section: Methodssupporting

confidence: 88%

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Increased sensitivity of the thyroid in iodine-depleted rats to the goitrogenic effects of thyrotropin

Bray¹

1968

J. Clin. Invest.

143

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Section: Methodssupporting

confidence: 92%

Section: Methodssupporting

confidence: 88%

Increased sensitivity of the thyroid in iodine-depleted rats to the goitrogenic effects of thyrotropin

Bray¹

1968

J. Clin. Invest.

143

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“…to 0.392±0.19%, if PTU is given together with HID. The data are in accord with data published by Astwood and Bissell (12). The diets were obtained from Altromin (Lage, Germany).…”

Section: Introductionsupporting

confidence: 68%

Reaccumulation of thyroglobulin and colloid in rat and mouse thyroid follicles during intense thyrotropin stimulation. A clue to the pathogenesis of colloid goiters.

Gerber¹,

Studer²,

Conti³

et al. 1981

J. Clin. Invest.

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A B S T R A C T Since Marine's observations some 50 years ago, it has been generally accepted that colloid goiters invariably result from colloid repletion of originally hyperplastic goiters after cessation of the goitrogenic stimulus. However, clinical observations suggest that many goiters never go through a stage of hyperplasia, but are colloid-rich from the beginning.We have injected rats and mice with thyrotropin (TSH), three times a day for 4 d, while the animals were kept on an iodine-rich diet (HID). Additional groups of animals were fed an iodine-poor diet (LID) or a diet containing 0.15% propylthiouracil (PTU) or 1% sodium perchlorate (C104). At intervals, thyroid weight, DNA, iodine and thyroglobulin content, thyroglobulin iodination, and intracellular droplet formation were measured. Histologic sections were also prepared and stained with periodic acid Schiff. Furthermore, thyroxine concentration was measured in the serum.Thyroglobulin content dropped by -30% in HID animals but by 60% in all other groups 1 d after starting TSH. Thereafter, thyroglobulin reaccumulation occurred and droplet formation correspondingly decreased despite continuous heavy TSH stimulation. The largest amount ofthyroglobulin was reaccumulated in HID animals followed by the PTU/LID groups, whereas no reaccumulation was observed in the C104 group. Reaccumulation of thyroglobulin only occurred if there was concomitant organification of at least some iodine. The subsequent phases of depletion and re-

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“…In 1944, Astwood and Bissell [13] demonstrated that the administration of thiouracil to young rats averaging 100 grams in weight was followed by a nearly complete disappearance of iodine from the thyroid glands in five days and a threefold increase in the size of the glands in two weeks. Moreover, they also showed that this effect was inhibited by concurrent thyroxine administration, although the present study did not find that there is a significant difference between the effects of antithyroid drug alone and of antithyroid plus 1-thyroxine on the thyroid CT number.…”

Section: Discussionmentioning

confidence: 99%

Clinical Studies on Thyroid CT Number in Graves' Disease and Destructive Thyrotoxicosis.

Kamijo

1994

Endocr J

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EFFECT OF THIOURACIL ON THE IODINE CONTENT OF THE THYROID GLAND¹

Cited by 94 publications

References 0 publications

Increased sensitivity of the thyroid in iodine-depleted rats to the goitrogenic effects of thyrotropin

Increased sensitivity of the thyroid in iodine-depleted rats to the goitrogenic effects of thyrotropin

Reaccumulation of thyroglobulin and colloid in rat and mouse thyroid follicles during intense thyrotropin stimulation. A clue to the pathogenesis of colloid goiters.

Clinical Studies on Thyroid CT Number in Graves' Disease and Destructive Thyrotoxicosis.

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EFFECT OF THIOURACIL ON THE IODINE CONTENT OF THE THYROID GLAND1

Cited by 94 publications

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Increased sensitivity of the thyroid in iodine-depleted rats to the goitrogenic effects of thyrotropin

Increased sensitivity of the thyroid in iodine-depleted rats to the goitrogenic effects of thyrotropin

Reaccumulation of thyroglobulin and colloid in rat and mouse thyroid follicles during intense thyrotropin stimulation. A clue to the pathogenesis of colloid goiters.

Clinical Studies on Thyroid CT Number in Graves' Disease and Destructive Thyrotoxicosis.

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EFFECT OF THIOURACIL ON THE IODINE CONTENT OF THE THYROID GLAND¹