Effect of thoracic duct fistula on canine renal homografts

Slafsky, F; Kriek, H; Murray, Joseph E.

doi:10.1016/0022-4804(67)90092-3

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1970

1972

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“…This agent has been used to attempt induction of graft tolerance following experimental renal allotransplantation (Calne et al, 1965 ;Casciani and Cortesini, 1967;Gertner et al, 1969;Green et al, 1969;Slafsky et al, 1967;Starzl et al, 1967). Calne initially noted improved renal allograft survival in dogs treated with various preparations of PHA in combination with azathioprine.…”

Section: Introductionmentioning

confidence: 96%

The effects of phytohemagglutinin in treated and untreated dog renal allografts

Murphy

Groenewald

Brede

et al. 1970

Journal of Surgical Oncology

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Dogs undergoing renal allografts were treated with phytohemagglutinin‐M (PHA‐M) with and without azathioprine before and after transplantation. PHA‐M treatment was associated with histological evidence of decreased renal allograft rejection and minimal azotemia. PHA‐M‐treated animals had marked leukocytosis postoperatively and, unlike untreated control animals or azathioprine‐treated dogs, had sustained elevations in total lymphocyte levels. However, PHA‐M treatment did not decrease survival due to associated drug toxicity manifested by a distemper‐like syndrome not observed in other concurrently evaluated animals.

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Section: Introductionmentioning

confidence: 96%