Effect of Three Androgen Indexes (FAI, FT, and TT) on Clinical, Biochemical, and Fertility Outcomes in Women with Polycystic Ovary Syndrome

Zhang, Duojia; Gao, Jingshu; Liu, Xuekui; Qin, Huichao; Wu, Xiaoke

doi:10.1007/s43032-020-00316-1

Cited by 10 publications

(8 citation statements)

References 32 publications

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“…These findings suggest that a shorter time from PCOS diagnosis or lower BMI at baseline is associated with a greater likelihood of resumption of menses in PCOS patients with obesity after LSG. Growing evidence has demonstrated that hyperandrogenemia is significantly associated with long and irregular menstruation in women with PCOS, 45 , 46 and ovarian hyperandrogenism can inhibit folliculogenesis and lead to polyfollicular morphology. 47 , 48 In accordance with previous studies, our findings indicate that a high circulating TT level was an independent risk factor for the restoration of menstrual regularity in PCOS patients with obesity after LSG.…”

Section: Discussionmentioning

confidence: 99%

Predictive Factors of Menstrual Recovery After Laparoscopic Sleeve Gastrectomy in Polycystic Ovary Syndrome Women with Obesity

Cai¹,

Zhang²,

Gao³

et al. 2023

DMSO

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Objective To explore the predictors of menstrual recovery in polycystic ovary syndrome (PCOS) women with obesity following laparoscopic sleeve gastrectomy (LSG). Methods A total of 88 PCOS patients with obesity and 76 control patients with obesity aged 18–45 years were enrolled between May 2013 and December 2020. PCOS was diagnosed using the Rotterdam diagnostic criteria (2003). Anthropometric measurements, biochemical parameters, sex hormones, and circulating fibrinogen-like protein 1 (FGL-1) levels were collected before and six-month after LSG. The data on postoperative menstrual status, body weight, and fertility were obtained through telephone follow-ups for all individuals with PCOS. Results Patients with PCOS were followed up for at least six months after surgery, and the mean follow-up time was 3.23 years. At 6 months after LSG, circulating total testosterone (TT), calculated free testosterone (cFT), and FGL-1 levels declined significantly. The mean percent excess weight loss (%EWL) and percent total weight loss (%TWL) in PCOS patients at the final follow-up was 97.52% ± 33.90% and 31.65% ± 10.31%, respectively. The proportion of regular menstruation in PCOS patients significantly increased within six months (75.86% vs 0.03% at baseline). In the logistic regression analysis, time from PCOS diagnosis (P=0.007), body mass index (BMI) (P=0.007), TT (P=0.038) at baseline were demonstrated to be independent predictive factors for the regular menstruation in women with PCOS and obesity within 6 months after LSG. Conclusion In PCOS patients with obesity, time from PCOS diagnosis, BMI, and TT levels at baseline were independently and negatively associated with menstrual recovery within 6 months after LSG, which could be applied in preoperative evaluation.

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Section: Discussionmentioning

confidence: 99%

Predictive Factors of Menstrual Recovery After Laparoscopic Sleeve Gastrectomy in Polycystic Ovary Syndrome Women with Obesity

Cai¹,

Zhang²,

Gao³

et al. 2023

DMSO

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“…Moreover, growing evidence has demonstrated that the menstrual cycle abnormality appeared to be associated with more pronounced insulin resistance and hyperandrogenemia in PCOS [ 38 , 39 ], as insulin resistance can induce oligo-or anovulation and cause menstrual cycle irregularity by exacerbating hyperandrogenemia and disrupting follicular growth [2,40 ]. In addition, previous studies showed that hyperandrogenemia was signi cantly associated with long and irregular menstruation in women with PCOS [ 41 ]. Ovarian hyperandrogenism can inhibit folliculogenesis and lead to poly-follicular morphology, which can disrupt the menstrual cycle.…”

Section: The Menstrual Status Bmi and Use Of Oral Contraceptives Of Pcos Women With Obesity After Lsgmentioning

confidence: 99%

Predicting Menstrual Recovery After Laparoscopic Sleeve Gastrectomy in Polycystic Ovary Syndrome Women With Obesity

Cai

Zhang

Gao

et al. 2021

Preprint

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Objectives: To investigate the recovery of menses in polycystic ovary syndrome (PCOS) women with obesity after laparoscopic sleeve gastrectomy (LSG), and to explore the predictors for menstrual recovery. Methods: A total of 88 PCOS patients with obesity and 76 control patients with obesity aged 18-45 years were enrolled between May 2013 and December 2020. Preoperative clinical characteristics, metabolic parameters and sex hormones were collected. Postoperative menstrual status, body weight and use of oral contraceptives were obtained through telephone follow-up. Results: Patients with PCOS were followed up for at least six months after surgery, and the mean follow-up time was 3.23 years. About 24.66% of patients with PCOS started their first menstruation after LSG within 7 days, and 79.52% patients had regular menstruation at six months after LSG. In logistic regression analyses, duration of PCOS ≤4.5 years (P=0.007), number of preoperative menstruation per year >4.0 times/year (P=0.045), homeostatic model assessment of insulin resistance (HOMA-IR) ≤7.3 (P=0.020) and total testosterone (TT) ≤1.5 nmol/L (P=0.029) at baseline were significantly associated with menstrual resumption in PCOS patients within 6 months after LSG. After adjusting confounders, combination of four clinical indices at baseline could effectively predict menstrual recovery in PCOS patients within 6 months after LSG (AUC=0.837, [95%CI: 0.735-0.939], P<0.001). Conclusion: Overall, the combination of PCOS duration, menstruations per year, HOMA-IR and TT at baseline could be used as an effective tool for the prediction of menstrual recovery in PCOS patients within 6 months after LSG, which can be applied in preoperative evaluation.

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“…In this study, SGLT‐2i showed the most beneficial improvements in metabolic parameters among drug classes. Interestingly, compared to either drug alone, the combination of metformin and GLP‐1 agonist demonstrated the most favourable free androgen index profile, a marker of quality of life and ovulatory health in patients with PCOS 140–142 . This might suggest that the combination of metformin and SGLT‐2i might present similar synergistic effects, albeit trials of this nature have yet to be developed.…”

Section: Effects Of Sglt2 Inhibitors On Pcosmentioning

confidence: 99%

Cardiometabolic effects of SGLT2 inhibitors on polycystic ovary syndrome

Lempesis

Apple

Duarte

et al. 2023

Diabetes Metabolism Res

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Polycystic ovary syndrome (PCOS) is a complex endocrinopathy affecting many women of reproductive age. Although its physiology is poorly understood, hyperandrogenemia and insulin resistance play a pivotal role in this complex syndrome, predisposing patients to a variety of cardiovascular and metabolic modalities. Current therapeutic options, including lifestyle modifications and medications, often do not satisfactorily improve clinical outcomes. SGLT2 inhibitors (SGLT‐2i) are a novel option which can potentially improve many hormonal and metabolic parameters for patients with PCOS, though the net cardiovascular effects remain under investigation in this population of patients with PCOS. Overall, the use of SGLT‐2i may be associated with beneficial somatometric, metabolic and hormonal outcomes of PCOS. To date, all available studies have recorded body mass index, waist and hip circumference, and fat mass reductions, improved insulin and androgen levels, and reduced blood pressure. The aim of the present review is to summarise PCOS‐related manifestations and mechanisms leading to cardiovascular disease, to explore the cardiometabolic impact of SGLT2i on PCOS, and to critically analyse the cardiometabolic and hormonal outcomes of the recent studies on the use of SGLT2i in women with PCOS.

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Effect of Three Androgen Indexes (FAI, FT, and TT) on Clinical, Biochemical, and Fertility Outcomes in Women with Polycystic Ovary Syndrome

Cited by 10 publications

References 32 publications

Predictive Factors of Menstrual Recovery After Laparoscopic Sleeve Gastrectomy in Polycystic Ovary Syndrome Women with Obesity

Predictive Factors of Menstrual Recovery After Laparoscopic Sleeve Gastrectomy in Polycystic Ovary Syndrome Women with Obesity

Predicting Menstrual Recovery After Laparoscopic Sleeve Gastrectomy in Polycystic Ovary Syndrome Women With Obesity

Cardiometabolic effects of SGLT2 inhibitors on polycystic ovary syndrome

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