Effect of Three Days Nifedipine Administration on Thyroid Response to TSH

Lalau, J. D.; Miteljan, E; Arlot, S; Quichaud, J

doi:10.1055/s-2007-1011732

Cited by 2 publications

(3 citation statements)

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“…Previous investigations with several dihydropyridines failed to show any effect on iodothyronines in serum (Zofkova et al 1983;Lalau et al 1987;Katzman et al 1987). In these studies, however, much lower doses were employed.…”

Section: ' Discussionmentioning

confidence: 95%

“…Verapamil is considered to have an inhibitory influence on pituitary secretion of thyroid stimulating hormone (TSH) both in vivo and in vitro (Eto et al 1974;Barbarino & De Marinis 1980;Geras et al 1982;De Marinis et al 1987). However, the role of dihydropyridine-type calcium antagonists concerning serum TSH is controversial (Struthers et al 1983;Teba et al 1985;Haitas et al 1986;Yamada et al 1986), whereas agreement exists on the lacking influence of dihydropyridines on thyroid hormones in serum (Zofkova et al 1983;Yamada et al 1986;Lalau et al 1987;Katzman et al 1987).…”

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confidence: 99%

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Thyroid Status and Hepatic Thyroxine Deiodinating Activity under High‐Dose Long‐Term Nitrendipine

Wieberneit

Wolf

Keck

1992

Pharmacology & Toxicology

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The influence of high doses of oral nitrendipine on the hypophyseal-thyroid axis and on peripheral thyroxine metabolism was studied in baboons. Administration of 320 mg oral nitrendipine per kg body weight (b.wt.) for three months caused a hypothyroid state with decreased values for thyroxine and reverse triiodothyronine, elevated TSH, but unchanged triiodothyronine; the lower doses investigated (24 and 48 mg/kg b.wt.) were without any effect. High doses of nitrendipine concomitantly increased hepatic 5'-deiodinating activity by a rise in Vmax, which could be attributed to an increase in the deiodinating enzyme content. Normal T3 serum levels in the presence of low T4 serum concentrations under high dose nitrendipine can be ascribed, at least in part, to the enhanced peripheral 5'-deiodination.

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Section: ' Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

Thyroid Status and Hepatic Thyroxine Deiodinating Activity under High‐Dose Long‐Term Nitrendipine

Wieberneit

Wolf

Keck

1992

Pharmacology & Toxicology

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“…But no association between ACEI and ARB treatment with thyroid function change was found with euthyroid ones in this study, in accordance with other clinical studies ( Hume et al, 1990 ; Andjelkovic et al, 2016 ), conflicting with an animal study ( Vranckx et al, 1995 ). The increased intracellular availability of Ca 2+ plays an important role in the regulation and secretion of thyroid hormones ( Lalau et al, 1987 ). Studies indicated that CCB could interfere with thyroid function through pituitary ( Brabant et al, 1989 ; Roussel et al, 1995 ; Roussel et al, 1997 ), thyroid ( Jangid, 1993 ; Pedemonte et al, 2005 ), and peripheral thyroid physiological process ( Capen, 1994 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Antihypertensive Drugs on Thyroid Function in Type 2 Diabetes Patients With Euthyroidism

et al. 2022

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Objective: There is little literature about whether antihypertensive drugs would affect thyroid function in patients with euthyroid type 2 diabetes, which was significant in maintaining a proper balance of thyroid function. A retrospective cohort study was conducted to evaluate the influence of antihypertensive drugs on thyroid function in patients with type 2 diabetes with euthyroidism.Design and Methods: The study involved dividing 698 patients with antihypertensive monotherapy into five groups according to the antihypertensive drugs they were treated with. Antihypertensive drugs included in this study were β-blockers, angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), and calcium channel blockers (CCB). The clinical data and thyroid function level between or within groups were compared. Multiple logistic regression analysis was conducted to evaluate the association of antihypertensive drugs with thyroid function level.Results: Selective β1- adrenergic receptor blockers treatment was related to thyroid-stimulating hormone (TSH), increasing in patients with diabetes and euthyroidism as shown by multiple logistic regression analysis. The association existed after adjustment for confounding factors. No significant influence on thyroid function was found among other antihypertensive drugs.Conclusion: These data show the TSH-lifting effect of selective β1-adrenergic receptor blockers in patients with type 2 diabetes with euthyroidism.

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Effect of Three Days Nifedipine Administration on Thyroid Response to TSH

Cited by 2 publications

References 4 publications

Thyroid Status and Hepatic Thyroxine Deiodinating Activity under High‐Dose Long‐Term Nitrendipine

Thyroid Status and Hepatic Thyroxine Deiodinating Activity under High‐Dose Long‐Term Nitrendipine

Effects of Antihypertensive Drugs on Thyroid Function in Type 2 Diabetes Patients With Euthyroidism

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