Effect of three different anaesthetic agents on the postoperative production of cardiac troponin T in paediatric cardiac surgery

Abstract

Midazolam, propofol, and sevoflurane appear to provide equal myocardial protection in paediatric cardiac surgery when using cTnT as a marker of myocardial damage.

Volatile Anesthetic-Induced Cardiac Protection: Molecular Mechanisms, Clinical Aspects, and Interactions With Nonvolatile Agents

“…However, troponin levels were nearly twice as high in patients receiving midazolam and propofol, suggesting a lack of power. 152 Experimental studies supported beneficial effects of benzodiazepine antagonists. Flumazenil protected cardiac myozytes from hypoxic damage via the PKC, ROS, and K ATP channel prosurvival axis.…”

Biomonitors of cardiac injury and performance: B-type natriuretic peptide and troponin as monitors of hemodynamics and oxygen transport balance

“…In addition, cTnT levels before cardiovascular surgery predicted postoperative survival. Finally, perioperative troponin measurements have been used as a gauge of therapeutic success with a variety of intraoperative protocols (142)(143)(144)(145)(146)(147)(148).…”

The effects of interrupted or continuous administration of sevoflurane on preconditioning before cardio‐pulmonary bypass in coronary artery surgery: comparison with continuous propofol

“…While numerous laboratory investigations have shown that anaesthetic preconditioning is an important protective mechanism in a variety of species and tissues [1][2][3][4], the results of studies performed in humans have been more equivocal. While there are several studies reporting a beneficial effect with respect to myocardial cell damage [5][6][7], myocardial function [8,9], and improved outcome [10,11], other investigators have been unable to confirm these promising findings [12][13][14][15]. In studies where the volatile anaesthetic is given continuously (i.e.…”