Effect of Three Different Doses of a Slow-Release Theophylline Formulation on Bronchial Response to Inhaled Methacholine in Asthmatic Patients

Ferrari, Marcello; Olivieri, M.; Lampronti, G; Biasin, C; Cascio, Vincenzo Lo

doi:10.1159/000196399

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…One of the most frequent simptoms associated with this is the bronchial hyperresponsiveness. Bronchial hyperreactivity (HRB) can be considered a major heterogeneous,phenomenon, depending on several conditions, in term of etiology and which gathers the features of a genuine syndrome if we consider the complexity of the mechanisms which produce and countless clinical implications [1,2,3].…”

Section: Introductionmentioning

confidence: 99%

The Role of Eosinophilic Cationic Proteins, Total IgE and Eosinophilia in Children with Bronchial Hyperresponsiveness

Ungureanu

Frecus

2016

ARS Medica Tomitana

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Bronchial hyperreactivity (HRB), is defined as an excessive bronchial constriction that acts as an exaggerated bronchoconstrictor of the airways. This occurs as a secondary action of a nonspecific stimuli. Taking as a starting point asthmatic patient, as the patient responds by bronchoconstriction action of various stimuli, the concept of bronchial hyperractivity gradually began to take shape. Bronchial hyperractivity (HRB) can be considered a major, heterogeneous phenomenon, depending on several conditions, in term of etiology and which gathers the features of a genuine syndrome if we consider the complexity of the mechanisms which produce and countless clinical implications.

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Section: Introductionmentioning

confidence: 99%

The Role of Eosinophilic Cationic Proteins, Total IgE and Eosinophilia in Children with Bronchial Hyperresponsiveness

Ungureanu

Frecus

2016

ARS Medica Tomitana

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Effect of once daily and twice daily sustained release theophylline formulations on daytime variation of bronchial hyperresponsiveness in asthmatic patients

Ferrari

Olivieri

Lampronti

et al. 1997

Thorax

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Abstractthe daytime, the protective activity against methacholine during the 12 hours of the Background -Previous studies evaluating monitoring period being constant. Furspirometric values and symptoms have thermore there was no difference in the shown that once daily theophylline admean FEV 1 between the two treatments at ministered in the evening produces greater 14.00 and 20.00 hours. stabilisation of the airway function in asthConclusions -In adults with stable bronmatic patients than the prototype theochial asthma treatment with a single dose phylline given twice a day. The aim of of Diffumal-24 administered in the eventhis study was to compare the effects on ing improved airflow obstruction and rebronchial responsiveness to methacholine duced bronchial hyperresponsiveness. of an ultrasustained release theophylline (Thorax 1997;52:969-974) formulation (Diffumal-24, Malesci, Florence, Italy) administered once a day, a Keywords: theophylline, bronchial hyperresponsivesustained release theophylline formulation ness, bronchial asthma. (Theo-Dur, Recordati, Milan, Italy) administered twice a day, and placebo. Methods -The study was performed in 12 Oral theophylline formulations are widely used adult patients with asthma using a ran-in the treatment of bronchial asthma. During domised, double blind, three phase, cross-the past 10 years increased knowledge of the over design. Each phase lasted seven days pharmacokinetics, availability of theophylline and was followed or preceded by at least assays, and the development of sustained rethree days of theophylline washout. Diffu-lease formulations have led to a safer and more mal-24 was administered once a day at effective use of the drug.1 The therapeutic ad-20.00 hours whereas Theo-Dur was given vantages of sustained release formulations have twice a day at 08.00 hours and 20.00 hours. mainly been attributed to their ability to reduce In each patient the total daily dose of theo-fluctuations in plasma theophylline conphylline was the same during both phases. centrations and, consequently, to keep serum The dose of the two active preparations levels of the xanthine within the narrow therawas titrated to individual needs before the peutic range during the 24 hours.2 For this beginning of the study and then given in reason, slow release theophylline formulations divided or once daily doses. At 08.00, 14.00, given twice a day are theoretically more effectand 20.00 hours on day 7 of each phase ive than the more recently introduced ulserum theophylline concentrations were trasustained release theophylline formulations measured and spirometric tests (FEV 1 ) designed to allow once a day dosing which and bronchial challenge with metha-produce larger fluctuations in serum levels of choline were also performed. the xanthine.

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Effect of Three Different Doses of a Slow-Release Theophylline Formulation on Bronchial Response to Inhaled Methacholine in Asthmatic Patients

Cited by 2 publications

References 8 publications

The Role of Eosinophilic Cationic Proteins, Total IgE and Eosinophilia in Children with Bronchial Hyperresponsiveness

The Role of Eosinophilic Cationic Proteins, Total IgE and Eosinophilia in Children with Bronchial Hyperresponsiveness

Effect of once daily and twice daily sustained release theophylline formulations on daytime variation of bronchial hyperresponsiveness in asthmatic patients

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