Effect of Thyrocalcitonin in Man

Effects of Calcitonin in Metastatic Bone Carcinoma, Osteoporosis, Polyostotic Fibrous Dysplasia and Hypercalcemia

“…The fall of serum magnesium after calcitonin administration was reported smaller than that of serum calcium (Foster et al, 1966). Our investigation also demonstrated that serum magnesium level did not change at least 5 hr after intramuscular administration of calcitonin in metastatic bone carcinoma (Table 2).…”

“…Although the dose of 4-8 MRC u./kg/day was proposed for Paget's disease (Bell et al, 1970), smaller dose was also effective in hypercalcemia (Foster et al, 1966;Haas and Dambacher, 1968). Haas (1968) demonstrated that generally speaking the smaller was the dose of calcitonin, the smaller the fall of serum calcium level, although the dose of 2-10 MRC u. showed the similar response as 50-100 MRC u. in some of the patients.…”

“…However, the smaller dose was also effective in lowering serum calcium level (Foster et al, 1966;Haas et al, 1968). In this report the transient and prolonged effects of small dose of porcine calcitonin were investigated in metastatic bone carcinoma, osteoporosis, fibrous dysplasia and hypercalcemia.…”

An evaluation of antibodies and clinical resistance to salmon calcitonin

“…However, in an occasional patient, a marked antibody response may occur which interferes with the therapeutic use of the hormone. INTRODUCTION Calcitonin (porcine) was first administered to man in 1966 (1). Since then porcine, salmon, and human calThis work was presented in part to the American Federation for Clinical Research, Carmel, Calif., 3 February 1972. Dr. Singer is a clinical investigator of the Veterans Administration.…”

A Clinical Trial with Calcitonin

“…Porcine calcitonin has been shown to be active in man (Milhaud et al, 1965, Foster et al, 1966. It is believed to act on bone by inhibiting mineral resorption.…”