EFFECT OF THYROID FUNCTION ON NUMBER OF Na-K PUMPS IN HUMAN SKELETAL MUSCLE

Kjeldsen, Keld; Gøtzsche, Carl-Otto; Clausen, Torben; Nørgaard, Aage; Thomassen, Anne

doi:10.1016/s0140-6736(84)91996-2

Cited by 109 publications

(42 citation statements)

References 11 publications

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“…During dissection it was evident that hyperthyroid organs were much more richly innervated by blood vessels than their controls and hypothyroid organs less (data not shown). It is well established from studies in rat and human skeletal muscle that ouabain binding site density reflects the total population of functional Na + /K + pumps (Clausen 1998), which changes proportionally to thyroid status (Kjeldsen et al 1984, 1986, Everts 1996. Table 2 shows that soleus muscle from hyperthyroid rats expressed significantly more ouabain binding sites than their controls, whereas hypothyroid rats expressed fewer binding sites.…”

Section: Ouabain Binding Assaymentioning

confidence: 97%

Activities of UDP-glucuronyltransferase, beta-glucuronidase and deiodinase types I and II in hyper- and hypothyroid rats

Heide

Joosten²,

Everts³

et al. 2004

Journal of Endocrinology

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We have investigated the hypothesis that uridine 5 -diphosphate (UDP)-glucuronyltransferases (UGTs) and -glucuronidase are jointly involved in a mechanism for the storage and mobilization of iodothyronine metabolites in liver, kidney, heart and brain. Specifically, we predicted UGT activities to decrease and increase respectively, and -glucuronidase activity to increase and decrease respectively in hypo-and hyperthyroidism. To this end we have studied the effects of thyroid status on the activities of different enzymes involved in thyroid hormone metabolism in liver, kidney, heart and brain from adult rats with experimentally induced hypo-and hyperthyroidism. We used whole organ homogenates to determine the specific enzyme activities of phenol-and androsteron-UGT, -glucuronidase, as well as iodothyronine deiodinase types I and II. Deiodinase type I activities in liver and kidney were decreased in hypothyroid animals and, in liver only, increased in hyperthyroidism. Deiodinase type II activity was increased in hyperthyroid rat kidney only. Interestingly, in the heart, deiodinase type I-specific activity was increased fourfold, although the increase was not statistically significant. Cardiac deiodinase type I activity was detectable but not sensitive to thyroid status. Hepatic phenol-UGT as well as androsteron-UGT activities were decreased in hypothyroid rats, with specific androsteron-UGT activities two to three orders of magnitude lower than phenol-UGT activities. Both UGT isozymes were well above detection limits in heart, but appeared to be insensitive to thyroid status. In contrast, cardiac -glucuronidase activity decreased in hypothyroid tissue, whereas the activity of this enzyme in the other organs investigated did not change significantly.In summary, cardiac -glucuronidase, albeit in low levels, and hepatic phenol-UGT activities were responsive only to experimental hypothyroidism. Although a high basal activity of the pleiotropic -glucuronidase masking subtle activity changes in response to thyroid status cannot be ruled out, we conclude that hepatic, renal and cardiac UGT and -glucuronidase activities are not regulated reciprocally with thyroid status.

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Section: Ouabain Binding Assaymentioning

confidence: 97%

Activities of UDP-glucuronyltransferase, beta-glucuronidase and deiodinase types I and II in hyper- and hypothyroid rats

Heide

Joosten²,

Everts³

et al. 2004

Journal of Endocrinology

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“…Similarly, patients with thyroid carcinoma who were older than 60 years and receiving RAS-blocker drugs, significantly had higher risk of developing hyperkalemia following bilateral total thyroidectomy induced hypothyroidism (14). Different mechanisms may be responsible for the relationship between hyperkalemia and low FT3 (19)(20)(21). In the presence of overt hypothyroidism, angiotensin and angiotensin-converting enzyme level decreases and renin increases and / or decreases.…”

Section: Discussionmentioning

confidence: 99%

“…In the presence of overt hypothyroidism, angiotensin and angiotensin-converting enzyme level decreases and renin increases and / or decreases. In addition, intrarenal RAS system is inhibited, AT1 receptor expression might decrease and AT2 receptor activation is enhanced (19)(20)(21). However, in the course of renal failure but without overt hypothyroidism, low T3 levels may cause RAS system inhibition and / or may lead to differences in receptor levels and this process may increase the risk of hyperkalemia.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Low FT3 Level on Kidney Disease Progression and Potassium Levels in Euthyroid Adult Patients with Solitary Kidney

Tatar¹,

Uslu²,

Atakaya³

et al. 2017

Turk Neph Dial Transpl

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OBJECTIVE: The aim of this study was to investigate the effect of low FT3 levels on CKD progression and hyperkalemia in euthyroid patients with solitary kidney. MATERIAL and METHODS:Seventy-six solitary kidney outpatients were enrolled in the study. Patients with a preexisting thyroid disease were excluded. The baseline and final laboratory parameters were evaluated. Serum Thyroid hormones (TSH, FT3 and FT4) were measured at baseline. RESULTS:The mean age of the patients was 50.4 ± 13.8 years and mean follow-up was 43 ± 29 months. Of the patients, 24% had progressive CKD and 19.7% developed hyperkalemia. Patients with a progressive course had lower FT3 levels (2.71 ± 0.34 vs. 3.17±0.47; p <0.001). Similarly hyperkalemic patients had lower FT3 values (2.77 ± 0.34 vs. 3.13 ± 0.49; p = 0.011). FT3 levels were negatively correlated with, age, history of hypertension and serum potassium level and positively correlated with serum albumin and eGFR levels. In multivariate regression analysis, FT3 levels were independently associated with progression of CKD. Low eGFR and RAS-blocker use was independently associated with the development of hyperkalemia. CONCLUSION:In patients with solitary kidney, low FT3 level is associated with the progression of CKD. In addition, development of hyperkalemia is common in CKD patients with low FT3 levels. KEy wORDS:Chronic kidney disease, Hyperkalemia, Low T3 syndrome, Solitary kidney, Thyroid hormones Öz AMAÇ: Çalışmanın amacı ötiroid soliter böbrekli hastalarda düşük serbest T3 seviyelerinin, KBH ilerlemesi ve hiperkalemi üzerine etkilerini incelemektir. GEREÇ ve yÖNTEMLER:Poliklinikte izlenen 76 tek böbrekli erişkin hasta çalışmaya dahil edildi. Tiroid hastalığı olanlar çalışma dışı bırakıldı. Başlangıç ve son kontrol laboratuvar sonuçları değerlendirildi. Tiroid hormon testlerine (TSH, sT4 ve sT3) başlangıçta bakıldı. BULGULAR:Hastaların yaş ortalamaları 50,4±13,8 yıl ve ortalama takip süresi 43±29 aydı. Hastaların %24'de KBH'da ilerleme ve %19,7'de hiperkalemi gelişti. KBH'da ilerleme gösteren hastalarda sT3 seviyeleri daha düşüktü (2,71±0,34 vs. 3,17±0,47; p <0,001). Benzer şekilde hiperkalemi gelişen hastalarda sT3 seviyeleri daha düşüktü (2,77±0,34 vs. 3,13±0,49; p =0,011). sT3 seviyesi yaş, hipertansiyon öyküsü ve potasyum düzeyi ile negatif, serum albümin ve GFH ile pozitif koreleydi. Çoklu analizde; sT3 düzeyi KBH progresyonu ile, hiperkalemi gelişimi ise düşük GFH ve RAS bloker kullanımıyla bağımsız ilişkiliydi. SONUÇ:Soliter böbrekli hastalarda düşük serbest T3 seviyeleri KBH ilerlemisi ile ilişkilidir. Düşük sT3 seviyeli KBH hastalarında hiperkalemi gelişimi sıktır.

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“…In contrast studies in humans give equivocal results, and for example may even show an increase in free T 4 in patients with Cushing disease, followed by a fall after surgery [34]. As thyroid hormones are important regulators of Na + , K + -ATPase content in skeletal muscle [2][3][4][5][6], the possibly stimulating effect of corticosteroids may be overruled by the chronically low thyroid hormone concentrations in dogs with PDH, ultimately resulting in decreased Na + , K + -ATPase contents. Similarly, because hypophysectomy and hormone replacement therapy was associated with normalization of plasma T 4 concentration, this may have contributed to restoration of Na + , K + -ATPase content.…”

Section: Hormonal Regulation Of Na + K + -Atpase Contentmentioning

confidence: 99%

Na+, K+-ATPase content in skeletal muscle of dogs with pituitary-dependent hyperadrenocorticism

Schotanus

Meij

Vos

et al. 2006

Domestic Animal Endocrinology

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Several hormones regulate Na + , K + -ATPase content in the muscle cell membrane, which is essential for maintaining muscle cell excitability. Chronic glucocorticoid excess is associated with muscle weakness and reduced endurance. We hypothesized that chronic glucocorticoid excess affects Na + , K + -ATPase content in canine skeletal muscle, and contributes to reduced endurance and muscle weakness associated with pituitary-dependent hyperadrenocorticism (PDH) in dogs. Therefore, Na + , K + -ATPase content in skeletal muscle was evaluated before and after hypophysectomy and hormone replacement (cortisone and l-thyroxin) in dogs with PDH (n = 13), and in healthy controls (n = 6). In addition, baseline and exercise-induced changes in plasma electrolyte concentrations and acid-base balance were evaluated before and after hypophysectomy in dogs with PDH. Na + , K + -ATPase content of gluteal muscle in dogs with PDH was significantly lower than in control dogs (201 ± 13 pmol/g versus 260 ± 8 pmol/g wet weight; P < 0.01). Similar differences were found in palatine muscle. After hypophysectomy and on hormone replacement, Na + , K + -ATPase was increased (234 ± 7 pmol/g wet weight). Both plasma pH and base excess in dogs with PDH (7.44 ± 0.01; 1.7 ± 0.6 mmol/l, respectively) were significantly higher (P < 0.05) than after hypophysectomy and hormone replacement (7.41 ± 0.01; −0.2 ± 0.4 mmol/l, respectively). Exercise induced respiratory alkalosis, but did not result in hyperkalemia in dogs with PDH. In conclusion, chronic glucocorticoid excess in dogs with PDH is associated with decreased Na + , K + -ATPase content in skeletal muscle. This may contribute to reduce endurance in canine PDH, although dogs with PDH did not exhibit exercise-induced hyper- * Corresponding author.

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EFFECT OF THYROID FUNCTION ON NUMBER OF Na-K PUMPS IN HUMAN SKELETAL MUSCLE

Cited by 109 publications

References 11 publications

Activities of UDP-glucuronyltransferase, beta-glucuronidase and deiodinase types I and II in hyper- and hypothyroid rats

Activities of UDP-glucuronyltransferase, beta-glucuronidase and deiodinase types I and II in hyper- and hypothyroid rats

The Effect of Low FT3 Level on Kidney Disease Progression and Potassium Levels in Euthyroid Adult Patients with Solitary Kidney

Na+, K+-ATPase content in skeletal muscle of dogs with pituitary-dependent hyperadrenocorticism

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