Effect of thyroid hormone on the levels of erythrocyte carbonic anhydrase isozymes and 2,3-diphosphoglycerate in rabbits

Carbonic anhydrase isozymes of red blood cells in surgically treated hyperthyroidism.

“…Experimental results on mice and rabbits also showed that CA B of the animals administered with thyroid hormone decreased but CA C did not (Stern and Tashian 1976;Kondo et al 1978;Taniguchi et al 1978). In this study, CA C levels of both the young and the old red cells were significantly low on admission, and the young and the old red cells contained 78 and 88 per cent of CA C of normal adults, respectively.…”

“…Stern and Tashian (1976) reported that thyroid powder decreased the level of CA I in mouse erythrocytes, while CA II appeared to be unaffected. Kondo et al (1978) showed experimentally that CA B type decreased in rabbits administered with thyroidine and triiodothyronine, although CA C type was not changed. Taniguchi et al (1978) reported that thyroxine preferentially inhibited CA B synthesis of rabbit red cells without affecting that of CA C. Magid (1970) divided erythrocytes of a patient with hyperthyroidism into young and old cells, and measured CA B and CA C concentration.…”

Effects of Thyroid Hormone and Hypoxia on 2,3-Bisphosphoglycerate, Bisphosphoglycerate Synthase and Phosphoglycerate Mutase in Rabbit Erythroblasts and Reticulocytes in vivo

“…It has been reported that T 3 increases 2,3-BPG levels as a consequence of a direct effect of the hormone on BPGS activity [7, 8, 9, 10]. However, other studies showed no changes, or even a decrease, in 2,3-BPG levels under hyperthyroid conditions [11, 12, 13, 14, 15].…”

“…In whole blood and in purified erythrocytes, Miller et al [7], Snyder and Reddy [8, 9]and Kondo et al [10]found that T 3 increased 2,3-BPG levels. In contrast, Rose [11], Duhm and Gerlach [12], Czernik et al [13]and Torrance [14]reported that 2,3-BPG concentration was not altered under hyperthyroidism.…”

Zinc Deficiency States and Carbonic Anhydrase Isozyme in Experimental Hemolytic and Bleeding Anemia of Rabbits

“…The present work on the study of the rab bit erythrocyte CA-I and CA-II, was under taken as part of a research on the physiologi cal and pathological changes in the level of the isozymes [8][9][10][11][19][20][21][22] in an effort to investigate the correlation between the zincdeficiency states, and the level of carbonic anhydrase isozymes in rabbit erythrocytes, during experimental bleeding and hemolytic anemias. We found that along with a decrease in erythrocyte zinc content, carbonic anhy drase is also being affected similarly in anemic rabbits.…”