Effect of Thyroid Hormone Replacement Therapy on Ovarian Volume and Androgen Hormones in Patients with Untreated Primary Hypothyroidism

Müderris, İptisam İpek; Boztosun, Abdullah; Öner, Gökalp; Bayram, Fahri

doi:10.5144/0256-4947.2011.145

Cited by 11 publications

(10 citation statements)

References 29 publications

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“…11 Recently, it has been reported that elevated TSH levels may cause swelling and ovarian cyst formation in humans. 12 Thus, a possible involvement of TSH in ovarian carcinogenesis is worth exploring.…”

mentioning

confidence: 99%

Differential Transcriptional and Protein Expression of Thyroid-Stimulating Hormone Receptor in Ovarian Carcinomas

Revekka

Christina

Politi

et al. 2014

Int J Gynecol Cancer

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Our study describes for the first time alterations in TSHR expression both at mRNA and protein levels in ovarian carcinomas. The discrepancy between the decreased levels of the TSHR mRNA and the increased protein expression has already been described in thyroid carcinomas and might be due to alterations in its degradation by the ubiquitin system or other unknown mechanisms. Further analysis could elucidate the role of these findings in ovarian carcinogenesis.

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mentioning

confidence: 99%

Differential Transcriptional and Protein Expression of Thyroid-Stimulating Hormone Receptor in Ovarian Carcinomas

Revekka

Christina

Politi

et al. 2014

Int J Gynecol Cancer

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“…Elevated TSH in combination with normal serum FSH levels may get activated with FSH receptors, causing profound stimulation of ovarian follicles. 43,44,45 The aim of the therapy in delayed CH diagnosis is to optimize growth and development. Patients who receive treatment after a delayed diagnosis may not reach their target height, but can improve in physical growth, social interaction, and motor development.…”

Section: Discussionmentioning

confidence: 99%

Delayed diagnosis of congenital hypothyroidism in an adolescent results in avoidable complications: a case report

Ihsan

Rini

2017

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Delayed diagnosis of congenital hyporhyroidism (CH) remains a serious problem. A retrospective analysis of 1,000 CH cases in Turkey found a mean age of 49 months at the time of clinical diagnosis. Only 3.1% of cases were diagnosed during the neonatal period and 55.4% were diagnosed after 2 years of age.1 In Cipto Mangunkusumo Hospital, Jakarta, 53% cases were diagnosed at 1-5 years, 3.3% at 6-12 years, and 6.7% after 12 years of age, while the remainder were diagnosed at < 1 year of age.2 The majority of affected children exhibit signs and symptoms that are highly non-specific, as most infants with CH are asymptomatic at birth, and only 5% of cases can be diagnosed based on clinical examination during the first day of life.3 The other factors that contribute to delayed diagnosis are uneducated parents, who do not notice or dismiss the importance of mild/moderate deviations in physical and mental growth, as well as constipation, feeding difficulties, or other vague, non-specific symptoms in infancy. Parents are often unaware of the importance of early diagnosis and commencement of therapy for CH.4

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“…As the estriol is less potent than estradiol in feedback regulation of gonadotrophin secretion, so estriol in hypothyroid patients resulted in ovarian hyperstimulation and development of ovarian cysts. Also severe longstanding hypothyroidism leads to increased ovarian volume and/or cyst formation [2].…”

Section: Discussionmentioning

confidence: 99%

“…In spite of different etiology of both diseases, they have many features in common including substandard ovulation, decreased serum sex hormone-binding globulin, increased serum free testosterone, luteinizing hormone (LH) and cholesterol concentrations [6]. Some ovarian morphological changes that are typical of PCOS as the increased ovarian volume and the appearance of bilateral multicystic ovaries have been reported in various cases of primary hypothyroidism [2,7].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Thyroid Disorders on the Adult Female Albino Rats (Histological and Histochemical Study)

NS¹

2012

J Cytol Histol

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The ovary is an endocrine and exocrine gland that plays primary role in female development and reproductive activities. The proper function of the ovary is influenced by other endocrine glands like the thyroid gland, which is one of the most important endocrine glands of the body that affects many cells all over it .This work is designed to focus on the histological and histochemical changes in adult female albino rat`s ovary that happened due to thyroid gland disorders. Forty five adult female albino rats were used in this study. The rats were isolated from male rat for a month before starting the experiment then they are classified into three groups: control group, taken 0.5 ml physiologic saline orally for three months, hypothyroid group, they were taken carbimazol at a dose of 12 mg / kg B.wt. orally for 3 months, hyperthyroid group, they were taken eltroxin at a dose of 100-ug/ kg. B.wt.. Blood samples were taken for assay of serum T3 and T4. Ovaries were fixed in 10% formol saline and paraffin sections were prepared and stained by different stains: Heamatoxylin and Eosin, Periodic acid Schiff`s reaction, Methyl green pyronine and Masson `s trichrome .The result of the control rats showed the well-known histological pictures and histochemical reactions. The hypothyroid group showed an increased ovarian activity as an increase in the surface epithelial cells, excessive amount of collagen fibers, an increase in the amount of CHO materials and in DNA and RNA content. Regarding the hyperthyroid group there was degenerative changes in the ovarian follicles, decrease amount of collagen fibers and decrease in the amount of CHO materials in the ovarian follicles. The association between ovarian diseases and thyroid gland disorders deserves further attention as normal reproductive function needs approximately normal thyroid secretion.

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Effect of Thyroid Hormone Replacement Therapy on Ovarian Volume and Androgen Hormones in Patients with Untreated Primary Hypothyroidism

Cited by 11 publications

References 29 publications

Differential Transcriptional and Protein Expression of Thyroid-Stimulating Hormone Receptor in Ovarian Carcinomas

Differential Transcriptional and Protein Expression of Thyroid-Stimulating Hormone Receptor in Ovarian Carcinomas

Delayed diagnosis of congenital hypothyroidism in an adolescent results in avoidable complications: a case report

Effect of Thyroid Disorders on the Adult Female Albino Rats (Histological and Histochemical Study)

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