Effect of Thyroid-Stimulating Hormone Suppression Therapy on Cardiac Structure and Function in Patients With Differentiated Thyroid Cancer After Thyroidectomy: A Systematic Review and Meta-Analysis

Zhang, Hongling; Yang, Yanlong; Gao, Cuixia; Tian, Limin

doi:10.1016/j.eprac.2023.11.006

Cited by 2 publications

(2 citation statements)

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“…In the management of PTC patients, a degree of serum thyroid stimulating hormone (TSH) suppression is required depending on disease severity and response to therapy [1,5]. Thus, a substantial number of PTC patients are subjected to iatrogenic subclinical hyperthyroidism, which is known to have adverse effects on cardiac structure and function as well as bone health [6][7][8][9]. The beneficial effects of suppressed TSH on the outcomes of PTC patients are not well-established [10].…”

Section: Introductionmentioning

confidence: 99%

Recombinant Human TSH Fails to Induce the Proliferation and Migration of Papillary Thyroid Carcinoma Cell Lines

Kalampounias,

Varemmenou,

Aronis

et al. 2024

Preprint

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BackgroundIatrogenic subclinical thyrotoxicosis that leads to thyrotropin (TSH) suppression is required in the management of patients with papillary thyroid carcinoma (PTC) due to the mitogenic effects of TSH. Nevertheless, the available evidence supporting this practice is limited and weak. Our study seeks to explore the impact of human recombinant thyrotropin (rh-TSH) at clinically relevant doses on cell cultures of human normal and PTC follicular cells.Materials and MethodsA human normal thyroid cell line (Nthy-Ori 3-1) and cancerous cell lines (K1 and TPC-1) were transformed using the Lenti-X Tet-on Advanced system to overexpress the thyrotropin receptor (TSHR). Transformed and non-transformed cells were treated with escalating doses of rh-TSH (5–1,000 μIU/mL) under various conditions, such as the presence or absence of 0.5 U/mL insulin. Cell proliferation was estimated by the crystal violet assay, migration of the cells was assessed by a scratch test, and the expression levels of TSHR and thyroglobulin (Tg) were determined using RT-PCR and Western Blot.ResultsUnder the in-vitro culture conditions employed, rh-TSH was not adequate to induce either the proliferation rate or the migration potential in transformed and non-transformed cells. On the contrary, Tg expression was increased with rh-TSH under the same culture conditions.ConclusionOur experiments indicate that clinically relevant concentrations of rh-TSH cannot induce proliferation and migration in both normal and cancerous cell lines, even after overexpression of TSHR. Further research is warranted to dissect the molecular mechanisms underlying these effects. These results could translate into better management of PTC patients.

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Section: Introductionmentioning

confidence: 99%

Recombinant Human TSH Fails to Induce the Proliferation and Migration of Papillary Thyroid Carcinoma Cell Lines

Kalampounias,

Varemmenou,

Aronis

et al. 2024

Preprint

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show abstract

“…The management of thyroid cancer presents a multifaceted challenge, necessitating a comprehensive approach that includes surgery, radioactive iodine therapy, and thyroid-stimulating hormone (TSH) suppression through levothyroxine [1]. These interventions aim to improve patient outcomes, but concerns persist regarding their long-term effects [2][3][4]. The increasing number of thyroid cancer survivors underscores the importance of meticulous long-term management strategies [5].…”

mentioning

confidence: 99%

The Levothyroxine Odyssey: Navigating the Path of Survivorship in Thyroid Cancer

Kim

2024

Endocrinol Metab

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Effect of Thyroid-Stimulating Hormone Suppression Therapy on Cardiac Structure and Function in Patients With Differentiated Thyroid Cancer After Thyroidectomy: A Systematic Review and Meta-Analysis

Cited by 2 publications

References 36 publications

Recombinant Human TSH Fails to Induce the Proliferation and Migration of Papillary Thyroid Carcinoma Cell Lines

Recombinant Human TSH Fails to Induce the Proliferation and Migration of Papillary Thyroid Carcinoma Cell Lines

The Levothyroxine Odyssey: Navigating the Path of Survivorship in Thyroid Cancer

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