Effect of Thyrotropin Releasing Factor (TRF) of Ovine, Bovine, Porcine and Human Origin on Thyrotropin Release<i>in Vitro</i>and<i>in Vivo</i>

Bowers, Cyril; Redding, Tommie W.

doi:10.1210/endo-77-4-609

Cited by 41 publications

(5 citation statements)

References 12 publications

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“…TRH (also known as thyrotropin-releasing factor or thyroliberin) was first isolated and sequenced in the 1960s [ 68 – 70 ]. In mammals, TRH is produced in the hypothalamus, and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin from the anterior pituitary [ 71 , 72 ]. The recent discovery of a TRH receptor in the annelid Platynereis dumerilii indicates that the evolutionary origin of this neuropeptide signalling system predates the divergence of protostomes and deuterostomes [ 73 ].…”

Section: Resultsmentioning

confidence: 99%

Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms

et al. 2017

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Neuropeptides are a diverse class of intercellular signalling molecules that mediate neuronal regulation of many physiological and behavioural processes. Recent advances in genome/transcriptome sequencing are enabling identification of neuropeptide precursor proteins in species from a growing variety of animal taxa, providing new insights into the evolution of neuropeptide signalling. Here, detailed analysis of transcriptome sequence data from three brittle star species, Ophionotus victoriae, Amphiura filiformis and Ophiopsila aranea, has enabled the first comprehensive identification of neuropeptide precursors in the class Ophiuroidea of the phylum Echinodermata. Representatives of over 30 bilaterian neuropeptide precursor families were identified, some of which occur as paralogues. Furthermore, homologues of endothelin/CCHamide, eclosion hormone, neuropeptide-F/Y and nucleobinin/nesfatin were discovered here in a deuterostome/echinoderm for the first time. The majority of ophiuroid neuropeptide precursors contain a single copy of a neuropeptide, but several precursors comprise multiple copies of identical or non-identical, but structurally related, neuropeptides. Here, we performed an unprecedented investigation of the evolution of neuropeptide copy number over a period of approximately 270 Myr by analysing sequence data from over 50 ophiuroid species, with reference to a robust phylogeny. Our analysis indicates that the composition of neuropeptide ‘cocktails’ is functionally important, but with plasticity over long evolutionary time scales.

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Section: Resultsmentioning

confidence: 99%

Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms

et al. 2017

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“…TRH (also known as thyrotropin-releasing factor or thyroliberin) was first isolated and sequenced in the 1960s [68–70]. In mammals, TRH is produced in the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin from the anterior pituitary [71, 72]. The recent discovery of a TRH receptor in the annelid Platynereis dumerilii indicates that the evolutionary origin of this neuropeptide signaling system predates the divergence of protostomes and deuterostomes [73].…”

Section: Resultsmentioning

confidence: 99%

Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms

Zandawala

Moghul

Yáñez-Guerra

et al. 2017

Preprint

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Neuropeptides are a diverse class of intercellular signaling molecules that mediate neuronal regulation of many physiological and behavioural processes. Recent advances in genome/transcriptome sequencing are enabling identification of neuropeptide precursor proteins in species from a growing variety of animal taxa, providing new insights into the evolution of neuropeptide signaling. Here detailed analysis of transcriptome sequence data from three brittle star species, Ophionotus victoriae, Amphiura filiformis and Ophiopsila aranea, has enabled the first comprehensive identification of neuropeptide precursors in the class Ophiuroidea of the phylum Echinodermata. Representatives of over thirty bilaterian neuropeptide precursor families were identified, some of which occur as paralogs. Furthermore, homologs of endothelin/CCHamide, eclosion hormone, neuropeptide-F/Y and nucleobinin/nesfatin were discovered here in a deuterostome/echinoderm for the first time. The majority of ophiuroid neuropeptide precursors contain a single copy of a neuropeptide, but several precursors comprise multiple copies of identical or non-identical, but structurally-related, neuropeptides. Here we performed an unprecedented investigation of the evolution of neuropeptide copy-number over a period of ~270 million years by analysing sequence data from over fifty ophiuroid species, with reference to a robust phylogeny. Our analysis indicates that the composition of neuropeptide “cocktails” is functionally important, but with plasticity over long evolutionary time scales.

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“…Schreilber was the first to use the in vitro system of Saffran and Schally( 15) for detection af stimlaition of TSH release in vitro(24). However, the T R F preparations used in studies reported here are 1O, OOO-1OO, OOO times more aotive than thorie reported previously (26,27). Solomon (27) utilized it for partially purified T R F prepallations fm various s p i e s .…”

Section: Adidition Of T4 As In Experiments Shown Inmentioning

confidence: 83%

“…However, his criteria for TSH release were very indirect and based on activation of hyplophysial phosiphstarses. The effect Olf T R F on pituitary TSH release can be contrasted with the action of U-and P-MSH, which stimulate the thyroid (20)(21)(22), presumably by a direat action, since they are active in hypophysectomized animals (20) and have no effect on release of TSH from rat pituitaries in vitro ( 26,27). However, the T R F preparations used in studies reported here are 1O, OOO-1OO, OOO times more aotive than thorie reported previously (26,27).…”

Section: Adidition Of T4 As In Experiments Shown Inmentioning

confidence: 99%

In vitro Studies with Thyrotropin Releasing Factor.

Redding

1967

Experimental Biology and Medicine

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of hypothalamic PIF, and presumably thereby 3. Corbin, A., Cohen, A. I., Endocrinology, 1966, dep& pituitary prolactin secretion. Addendum.In agreement with the data presented here, we (Clemens, J. A., Meites, J., The Physiologist, 1967, v10, 144) found that implantation of prolactin into the medkn eminence of intact and castrate female rats reduced significantly pituitary weight and p'iltuitan=y pdactin mnwntration, and increased hypothalamic PIF content. Profound involution of the mammary glands was also olbsarved.

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Effect of Thyrotropin Releasing Factor (TRF) of Ovine, Bovine, Porcine and Human Origin on Thyrotropin Releasein Vitroandin Vivo

Cited by 41 publications

References 12 publications

Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms

Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms

Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms

In vitro Studies with Thyrotropin Releasing Factor.

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