Effect of thyrotropin releasing hormone on heart rate and visual evoked potentials in rats.

Tonoue, Teiichiro

doi:10.1507/endocrj1954.24.271

Cited by 6 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This indicates that, to elicit hyperthermia, TRH stimulated the adrenal medulla to increase catecholamine release. Brown (1981) has reported that central injection of TRH in rats resulted in elevation of plasma adrenaline and noradrenaline which may be related to increased heart rate (Tonoue, 1977) and blood pressure (Beale, White & Huang 1977) produced by TRH. It is known that catecholamines have a hyperthermic effect which may be due to the cutaneous vasoconstriction (Jansky, 1979) or to an action on brown adipose tissue (Smith & Horwitz, 1969;Jansky, 1979).…”

Section: Discussionmentioning

confidence: 99%

Thyrotropin releasing hormone‐induced hyperthermia in mice: possible involvement of adrenal and pituitary glands

Boschi

Nomoto

Rips

1983

British J Pharmacology

View full text Add to dashboard Cite

1To investigate the hyperthermic effect of thyrotropin releasing hormone (TRH) and its potentiation by exogenous catecholamines (CA), the role of the adrenal medulla and of the pituitary gland was studied in unoperated, adrenal-demedullated or hypophysectomized mice. 2 In unoperated mice, TRH 40 mg kg-l i.p. produced a hyperthermia which was accompanied by an increase in plasma noradrenaline (NA) and adrenaline (Ad). NA or Ad, both at a dose of 1 mg kg-I i.p., enhanced the TRH-induced hyperthermia.3 Adrenal demedullation suppressed the hyperthermia and the increase of plasma CA produced by TRH but not the potentiation of this hyperthermia by exogenous CA. 4 Hypophysectomy abolished the TRH-induced hyperthermia but not the increase of plasma CA or the potentiation of this hyperthermia by exogenous CA. 5These results suggest that, in mice, both the adrenal medulla and the pituitary gland play an essential role in TRH-induced hyperthermia but not in its potentiation.

show abstract

Section: Discussionmentioning

confidence: 99%