Effect of Tibial Plateau Angle on Cranial Cruciate Ligament Strain: An <i>Ex Vivo</i> Study in the Dog

Haynes, Kevin H.; Biskup, Jeffrey J; Freeman, Andrew L.; Conzemius, Michael G.

doi:10.1111/j.1532-950x.2014.12219.x

Cited by 27 publications

(37 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, current canine models of ACL reconstruction do not closely follow clinical protocol with respect to surgical instrumentation and technique. Intra‐articular grafts have also been associated with high failure rates in canine subjects because of difficulties in controlling load and motion in the early postoperative period in conjunction with the relatively high tibial slope of dogs . Therefore, development and validation of a pre‐clinical, large animal intra‐articular ACL reconstruction model that addresses current limitations is highly desirable.…”

mentioning

confidence: 99%

A canine hybrid double‐bundle model for study of arthroscopic ACL reconstruction

Cook

Smith

Pfeiffer

et al. 2015

Journal Orthopaedic Research

View full text Add to dashboard Cite

Development and validation of a large animal model for pre-clinical studies of intra-articular anterior cruciate ligament (ACL) reconstruction that addresses current limitations is highly desirable. The objective of the present study was to investigate a translational canine model for ACL reconstruction. With institutional approval, adult research hounds underwent arthroscopic debridement of the anteromedial bundle (AMB) of the ACL, and then either received a tendon autograft for "hybrid double-bundle" ACL reconstruction (n ¼ 12) or no graft to remain ACL/AMB-deficient (n ¼ 6). Contralateral knees were used as non-operated controls (n ¼ 18) and matched canine cadaveric knees were used as biomechanical controls (n ¼ 6). Dogs were assessed using functional, diagnostic imaging, gross, biomechanical, and histologic outcome measures required for pre-clinical animal models. The data suggest that this canine model was able to overcome the major limitations of large animal models used for translational research in ACL reconstruction and closely follow clinical aspects of human ACL reconstruction. The "hybrid double-bundle" ACL reconstruction allowed for sustained knee function without the development of osteoarthritis and for significantly improved functional, diagnostic imaging, gross, biomechanical, and histologic outcomes in grafted knees compared to ACL/AMB-deficient knees. A major roadblock to critically important assessments of ACL reconstruction methods and techniques relates to the suitability of animal models for fully addressing these guidelines. Most recent preclinical animal model studies for ACL research have used goats, sheep, or pigs.4-8 Unfortunately, these animal models have substantial limitations with respect to joint anatomy, arthroscopic capabilities, outcomes assessments and rehabilitation protocols, which makes clinical applicability of the data restricted. The anatomy of the canine knee (stifle) matches that of the human knee closely and clinically relevant outcomes assessments, diagnostic imaging, and rehabilitation strategies are readily employed in dogs.3 However, current canine models of ACL reconstruction do not closely follow clinical protocol with respect to surgical instrumentation and technique. Intra-articular grafts have also been associated with high failure rates in canine subjects because of difficulties in controlling load and motion in the early postoperative period in conjunction with the relatively high tibial slope of dogs.9-12 Therefore, development and validation of a pre-clinical, large animal intra-articular ACL reconstruction model that addresses current limitations is highly desirable. The objective of the present study was to describe and validate a translational canine model for allinside ACL reconstruction such that regulatory guidelines for pre-clinical studies are met. We hypothesized that the "hybrid double-bundle" model for arthroscopic ACL reconstruction would allow for sustained knee function without the development of osteoarthritis (OA), and for clin...

show abstract

mentioning

confidence: 99%

A canine hybrid double‐bundle model for study of arthroscopic ACL reconstruction

Cook

Smith

Pfeiffer

et al. 2015

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

“…Reducing the TPA had a protective effect on the CCL in dogs with early fiber tearing, as the CCL remained intact in all dogs with stable partial tears (group 1) in the TPLO study and in all but 1 dog in the CBLO study (Figure ). The protective effect results from decreased stress on the CCL after reducing the TPA, as determined by vitro studies and in clinical observations . Preservation of a functional CCL positively affected the appearance of the articular cartilage in group 1 dogs for both studies.…”

Section: Discussionmentioning

confidence: 93%

Second‐look arthroscopic findings after CORA‐based leveling osteotomy

Vasquez¹,

Hulse

Beale³

et al. 2017

Veterinary Surgery

View full text Add to dashboard Cite

show abstract

“…17 The TPA has been incriminated as a risk factor for cranial cruciate ligament disease based on evidence that a higher TPA was associated with increased cranial cruciate ligament strain. 18 Several studies have found that dogs affected with cranial cruciate ligament disease tend to have a higher TPA than unaffected dogs. 4,19 The mean TPA (28.6 degrees) of dogs predisposed to cranial cruciate ligament disease 4 was similar to the mean TPA of dogs in the >25 degrees group in this trial.…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Vertical Forces in Dogs Affected with Cranial Cruciate Ligament Disease and Tibial Plateau Angles Greater or Less than 25 Degrees

Ferrigno

Souza

Ferreira

et al. 2020

Vet Comp Orthop Traumatol

View full text Add to dashboard Cite

Objective Our objective was to compare the peak vertical force (PVF) and vertical impulse (VI) between dogs with cranial cruciate ligament disease and a tibial plateau angle (TPA) greater or less than 25 degrees. Methods A retrospective study was performed in 18 dogs with cranial cruciate ligament disease in which kinetic gait data were obtained with a pressure walkway system. Dogs were distributed in two groups: dogs with a TPA ≤ 25 degrees (n = 8) and dogs with a TPA > 25 degrees (n = 10). Mean PVF and VI in per cent of body weight (%BW) were compared between groups with an unpaired t-test (p < 0.05). Results Mean PVF and VI for the cranial cruciate ligament disease limb were 14.39%BW and 3.57%BWs for dogs with a TPA >25 degrees and 14.44%BW and 3.47%BWs for dogs with a TPA ≤ 25 degrees. There was no significant difference in mean PVF and VI between the groups. Conclusions The results suggest that there is no difference in kinetic data between dogs with cranial cruciate ligament disease and a TPA greater or less than 25 degrees. Other factors such as body weight, time of injury or meniscal lesion could be more related to the magnitude of cranial cruciate ligament disease lameness.

show abstract

Effect of Tibial Plateau Angle on Cranial Cruciate Ligament Strain: An Ex Vivo Study in the Dog

Abstract: The mechanical testing model used found CCL strain increased with increasing axial load regardless of the TPA. Decreasing TPA decreased strain in the intact CCL.

Cited by 27 publications

References 11 publications

A canine hybrid double‐bundle model for study of arthroscopic ACL reconstruction

A canine hybrid double‐bundle model for study of arthroscopic ACL reconstruction

Second‐look arthroscopic findings after CORA‐based leveling osteotomy

Comparative Analysis of Vertical Forces in Dogs Affected with Cranial Cruciate Ligament Disease and Tibial Plateau Angles Greater or Less than 25 Degrees

Contact Info

Product

Resources

About