Effect of tick-borne fever on liver and kidney function in dwarf-cross goats

Watson, A. D. J.; Duin, C. T. M. van; Knoppert, N.W.; Nieuwenhuijs, J.; Wensing, Th.; Miert, A. S. J. P. A. M. van

doi:10.1016/0007-1935(88)90028-0

Cited by 4 publications

(6 citation statements)

References 14 publications

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“…Similar to our case, subclinical E. ewingii infection also has been reported in dogs . However, laboratory findings reported in this goat, including lymphopenia, neutrophilic left shift, decreased ALP activity, and increased GGT activity are changes reported in association with experimental E. ewingii and natural A. phagocytophilum infections in goats . Decreased ALP activity in goats with Ehrlichia spp.…”

Section: Peripheral Blood Polymerase Chain Reaction (Pcr) Panel Resulsupporting

confidence: 88%

“…infection is a consistent and pathophysiologically interesting observation. It has been postulated that the activity of ALP, a zinc‐dependent enzyme, is correlated with the plasma concentrations of zinc, which decrease during rickettsemic episodes as a result of the release of endogenous pyrogens and acute phase mediators . The clinical relevance of mildly increased GGT activity in this goat is unclear because no other laboratory data indicated cholestasis.…”

Section: Peripheral Blood Polymerase Chain Reaction (Pcr) Panel Resulmentioning

confidence: 92%

“…The activity of SDH would have been a sensitive marker to screen for hepatic disease, but was not determined in this goat. Increased GGT activity also was related to altered hepatic metabolic activities associated with A. phagocytophilum infection in goats, and increased serum transaminase activities including GGT occur in association with E. ewingii ehrlichiosis in humans …”

Section: Peripheral Blood Polymerase Chain Reaction (Pcr) Panel Resulmentioning

confidence: 95%

“…can infect domestic goats. Anaplasma phagocytophilum (referred to as tick‐borne fever in Europe) and Ehrlichia ruminantium (heartwater disease, historically the organism was designated Cowdria ruminantium ) are well described, clinically and economically relevant tick‐transmitted diseases in Europe and Africa, respectively . The importance of other Ehrlichia spp.…”

Section: Peripheral Blood Polymerase Chain Reaction (Pcr) Panel Resulmentioning

confidence: 99%

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Naturally Occurring Ehrlichia ewingii and Mycoplasma sp. Co‐Infection in a Goat

Meichner

Qurollo

Anderson

et al. 2015

Veterinary Internal Medicne

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Section: Peripheral Blood Polymerase Chain Reaction (Pcr) Panel Resulsupporting

confidence: 88%

Section: Peripheral Blood Polymerase Chain Reaction (Pcr) Panel Resulmentioning

confidence: 92%

Section: Peripheral Blood Polymerase Chain Reaction (Pcr) Panel Resulmentioning

confidence: 95%

Section: Peripheral Blood Polymerase Chain Reaction (Pcr) Panel Resulmentioning

confidence: 99%

See 2 more Smart Citations

Naturally Occurring Ehrlichia ewingii and Mycoplasma sp. Co‐Infection in a Goat

Meichner

Qurollo

Anderson

et al. 2015

Veterinary Internal Medicne

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“…To our knowledge, complete blood counts and serum profiles have not been determined during the course of disease in cows after experimental infection with E. phagocytophila. In humans, horses, and goats, granulocytic ehrlichiosis results in changes in hepatic and renal enzyme activities (20,27).…”

mentioning

confidence: 99%

Laboratory findings in cows after experimental infection with Ehrlichia phagocytophila

Pusterla

Huder

Wolfensberger

et al. 1997

Clin Diagn Lab Immunol

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The goal of this study was to assess various hematological variables in 10 cows after experimental infection with Ehrlichia phagocytophila. Blood samples were collected at regular intervals for examination of leukocytes for Ehrlichia organisms and for determination of hematological and biochemical variables. In addition, PCR amplification was performed throughout the disease period on blood and milk samples for the detection of E. phagocytophila organisms. The time of seroconversion and the duration of serum titers indicating positivity were determined by indirect immunofluorescence. For all cows, E. phagocytophila organisms were first detected microscopically in leukocytes 5 to 8 days postinfection and could be demonstrated for a period of 6 to 14 days. For all cows, the appearance of E. phagocytophila organisms in leukocytes coincided with transient erythropenia, leukopenia, and thrombocytopenia and a decrease in hematocrit and hemoglobin concentration. For five lactating cows, E. phagocytophila organisms were identified in leukocytes of milk samples during the acute phase of the disease, which, we believe, has not previously been reported. E. phagocytophila DNA was detected in blood samples by nested PCR from 1 to 2 days before to 2 to 12 days after the organisms were identified microscopically. In milk samples, E. phagocytophila DNA was detected for an average of 11 days.

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Some pharmacokinetic data of aditoprim and trimethoprim in healthy and tick‐borne fever infected dwarf goats

Knoppert¹,

Nijmeijer²,

Duin³

et al. 1988

Vet Pharm & Therapeutics

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Aditoprim (AP) is a new dihydrofolate reductase inhibitor, which is structurally related to trimethoprim (TMP). The pharmacokinetics of AP (10 mg/kg) and TMP (20 mg/kg) were assessed in healthy dwarf goats. Therapeutic efficacy against rickettsial infections was tested in tick-borne fever (TBF) infected goats. The animals were given TMP (n = 5) or AP (n = 5) by i.v. injection, and subsequently the drugs were administered orally (same groups, similar doses). Finally, both groups were infected with TBF and the i.v. experiment was repeated. Plasma concentration-time curves for both drugs followed first-order two-compartment decay. For TMP, mean t1/2 beta +/- SEM (h) was 0.84 +/- 0.06 (i.v. control) and 0.90 +/- 0.06 (i.v. infected), respectively, whereas for AP values of 8.00 +/- 0.31 (i.v. control) and 10.28 +/- 0.67 (i.v. infected) were obtained (P less than 0.05). Mean Vd beta +/- SEM values (l/kg) were 3.84 +/- 0.27 (i.v. control) and 4.07 +/- 0.85 (i.v. infected) for TMP (NS) and 7.02 +/- 0.63 vs 9.29 +/- 0.21 (P less than 0.05) for AP. After i.v. injection, rumen fluid concentrations of AP were significantly (P less than 0.05) higher and more persistent than those of TMP. For AP, the plasma and rumen fluid concentrations at 3 h were 1.20 +/- 0.06 micrograms/ml and 0.85 +/- 0.17 microgram/ml, respectively. After oral administration of TMP, Cmax in plasma was 0.12 +/- 0.01 microgram/ml and the maximum was reached after 1.2 +/- 0.16 h; systemic bioavailability (F) was 10.3% (relative to AUC i.v.). Oral treatment with AP resulted in a Cmax value of 0.21 +/- 0.02 microgram/ml with Tmax of 22.5 +/- 1.65 h and a F value of 71%. Based on WBC, serum ALP and rectal temperature responses, it was concluded that both TMP and AP were inactive against Ehrlichia phagocytophila.

show abstract

Effect of tick-borne fever on liver and kidney function in dwarf-cross goats

Cited by 4 publications

References 14 publications

Naturally Occurring Ehrlichia ewingii and Mycoplasma sp. Co‐Infection in a Goat

Naturally Occurring Ehrlichia ewingii and Mycoplasma sp. Co‐Infection in a Goat

Laboratory findings in cows after experimental infection with Ehrlichia phagocytophila

Some pharmacokinetic data of aditoprim and trimethoprim in healthy and tick‐borne fever infected dwarf goats

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