The non-inversion tillage systems, including strip-till (ST), are the key element of conservation agriculture (CA). The aim of the 2012–2018 study has been to demonstrate the application of strip-till one-pass technology (ST-OP) on the farms of Central and Eastern Europe based on the use of Mzuri Pro-Til machines. There has also been an evaluation of the effect of that technology on the soil properties and the effects of crops growing. The scientific observations and field experiments were made, e.g., in Poland, Ukraine, Lithuania, the Czech Republic, Slovakia, the Eastern states of Germany, Belarus, Serbia, and Romania. ST-OP case study with the use of Mzuri Pro-Til machine can be applied for growing all the basic crops. Tillage with a simultaneous basic fertilization application and seeding made regularly for a few years in given field leads to favorable changes in the soil properties. As compared with the soil under conventional plough tillage (CT), the soil moisture, especially in the periods of rainfall deficit, the content of organic carbon and its fraction, the count of microorganisms and earthworms, as well as the enzymatic activity, are higher. This technology saves over 20–30 L ha−1 of fuel, respectively, compared to reduced tillage (RT) and CT. Plant emergence is uniform, dense canopies and crop yields—not lower and even higher than for tillage and seeding commonly applied in Central and Eastern Europe. ST-OP can be thus an important element of field plant production as part of CA and sustainable development.