Effect of time interval between two balloon inflations on ischemic preconditioning during coronary angioplasty

Tanaka, Takahiro; Oka, Yuki; Tawara, Ineko; Sada, Toshikatu; Kira, Yuji

doi:10.1002/(sici)1097-0304(199711)42:3<263::aid-ccd6>3.0.co;2-a

Cited by 11 publications

(4 citation statements)

References 16 publications

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“…5,9,18 Furthermore, the necessity for a sufficient intervening period of reperfusion is critical. 30 The distribution of initial balloon occlusion times in the UC group is shown in Figure 3. The mean occlusion time was 3.3Ϯ1.2 minutes in the group overall and 3.6Ϯ0.8 minutes in the 65 patients with an occlusion Ͼ1 minute.…”

Section: Discussionmentioning

confidence: 99%

“…The frequency of overall (any) CK elevation is within the range of previous reports, 11 although the frequency of substantial elevations (Ͼ5 times normal) was surprisingly low. This may reflect the underrepresentation of various atherectomy modalities, 30 the exclusion of saphenous vein graft interventions 31 from the study, differences in patient population, or differences in procedural conduct. The protocol used for the induction of preconditioning, however, precludes the initial use of atherectomy devices.…”

Section: Discussionmentioning

confidence: 99%

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Beneficial Impact of Preconditioning During PTCA on Creatine Kinase Release

Laskey

1999

Circulation

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Beneficial Impact of Preconditioning During PTCA on Creatine Kinase Release

Laskey

1999

Circulation

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“…As we performed repeated occlusions, these can also mimic ischemic preconditioning 23 , 24 . However it has been shown that: i) there was no evidence for ischemic preconditioning during a repeated vessel occlusion that lasts 2 minutes 25 , and ii) a minimal interval of 2 minutes is needed to observe a significant effect 26 . Therefore it is not likely that such phenomenon occurs.…”

Section: Discussionmentioning

confidence: 99%

A minimal resting time of 25 min is needed before measuring stabilized blood pressure in subjects addressed for vascular investigations

Comets

Nouni

Paillard

et al. 2017

Sci Rep

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Blood pressure (BP) measurement is a central element in clinical practice. According to international recommendations 3 to 5 minutes of resting is needed before blood pressure measurement. Surprisingly, no study has modelled the time course of BP decrease and the minimum resting-time before BP measurement. A cross-sectional bicentric observational study was performed including outpatients addressed for vascular examination. Using two automatic BP monitors we recorded the blood pressure every minute during 11 consecutive minutes. The data was analyzed by non-linear mixed effect regression. Systolic (SBP) and diastolic BPs were studied and we tested the effect of covariates on its evolution through log-likelihood ratio tests. We included 199 patients (66+/−13years old). SBP was found to decrease exponentially. Simulations based on the final model show that only half the population reaches a stabilized SBP (defined as SBP + 5 mmHg) after 5 min of resting-time while it takes 25 min to ensure 90% of the population has a stabilized SBP. In conclusion, our results and simulations suggest that 5 minutes are not enough to achieve a stabilized SBP in most patients and at least 25 minutes are required. This questions whether the diagnosis of hypertension can be reliably made during routine visits in general practitioners’ offices.

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“…ECG and cardiac pain. Previous studies have shown that an interval of more than 2 min between balloon inflations is required to achieve IP during angioplasty [27]. During the reperfusion intervals, the angioplasty balloons were withdrawn from the stenotic site and the guide wire was left at the same position.…”

Section: Figure 1 Summary Of Study Protocolmentioning

confidence: 99%

Effect of ischaemic preconditioning on regional release of inflammatory markers

et al. 2005

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Systemic markers of inflammation may be increased in patients after percutaneous coronary intervention. In the present study, we evaluated whether IP (ischaemic preconditioning) attenuated inflammation by activating KATP (ATP-sensitive potassium) channels in patients undergoing coronary angioplasty. Patients (n=36) undergoing angioplasty of a major left coronary artery were allocated randomly to one of four groups: a control group, a group receiving nicorandil (an agonist of KATP channels), an IP group or an IP group pretreated with glibenclamide (an antagonist of KATP channels). To measure the release of sCD40L, P-selectin and myeloperoxidase from the ischaemic region, blood samples were drawn simultaneously from the ascending aorta and the great cardiac vein before and 15 min after coronary angioplasty. At 15 min after angioplasty, a significant increase in sCD40L and P-selectin levels in the great cardiac vein in the control group was observed. IP- and nicorandil-treated patients did not show a significant change in sCD40L and P-selectin levels in response to angioplasty. However, the IP-induced attenuation of sCD40L and P-selectin release was abolished by administering glibenclamide. The change in myeloperoxidase levels mirrored those of sCD40L and P-selectin. The levels of inflammatory markers in the aorta remained stable throughout the study. Patients undergoing angioplasty had increased sCD40L and P-selectin levels in the ischaemic region. In conclusion, IP abolished angioplasty-induced myeloperoxidase release by preventing activated platelet-induced P-selectin release via a KATP-channel-initiated pathway. Therefore, in addition to its primary effect on cardioprotection, IP may also provide beneficial anti-inflammatory effects on the interaction between platelets and neutrophils.

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Effect of time interval between two balloon inflations on ischemic preconditioning during coronary angioplasty

Cited by 11 publications

References 16 publications

Beneficial Impact of Preconditioning During PTCA on Creatine Kinase Release

Beneficial Impact of Preconditioning During PTCA on Creatine Kinase Release

A minimal resting time of 25 min is needed before measuring stabilized blood pressure in subjects addressed for vascular investigations

Effect of ischaemic preconditioning on regional release of inflammatory markers

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