Mineral nutrition effect on anthracnose caused by Colletotrichum gloeosporioides, tuber rot by Botryodiplodia theobromae and yield in Dioscorea rotundata var. Iseosi was investigated in this study. The field plot used had been monoropped to Dioscorea species in the two previous consecutive years with only calcium nitrate fertilizer. But nitrogen and calcium in the plot soil were still below the critical (2% and 0.6 cmol kg -1 respectively) determined for optimum yam production (South West Nigeria). The field design was RCBD with 3 treatments of 0, 0.6, 1.2ml/l -1 Bounty fertilizer applied at 3 MAP, and three replicates. Bounty fertilizer favoured higher concentration of the phytoanticipins (with antimicrobial activity) flavonoid, lignin and tannin over the control. Leaf N and Mg had significant correlation with leaf flavonoid content (r = 0.7634, 0.6786). Leaf flavonoid had significant correlation with leaf lignin content, r = 0.7189. Leaf lignin in turn had significant correlation with leaf tannin content, r = 0.7556. Leaf Sulphur correlated significantly with leaf flavonoid and leaf phosphorus, r = 0.7218 and 0.8467 respectively. Bounty fertilizer also favoured higher leaf magnesium 234.73 and 230.27mg/100gdm (0.60ml/l -1 and 1.20ml/l -1 ) than the control, 182.40mg/100gdm. Leaf nitrogen, phosphorus and sulphur increased with bounty fertilizer treatment, then the control. Only leaf potassium was higher in the control (116.72mg/100gdm) than in the Bounty-fertilized plants with 87.31 and 87.53mg/100gdm in the 0.60mll -1 and 1.20mll -1 treatments.The following correlations were also significant respectively: Leaf N and Leaf P, S, r = 0.8484 and 0.9836 respectively.Leaf Ca and leaf Mg, r = 0.9192 Anthraconse incidence did not increase after the 3 MAP bounty fertilizer soil amendment. It was 11%, 6% and 0% in the control, 0.60ml/l -1 and 1.20ml/l -1 treatments respectively at 5 MAPS. It reduced to 5.6% (control and 0.60ml/l -1 treatment) and remained 0% in the 1.20ml/l -1 treatment at 6MAP. Severity of anthracnose was 1, category of resistant, both at 5 MAP and 6 MAPS across all the three treatments. The interplay/ enhancement of leaf minerals with the three phytochemicals/anticipants, as well as the latter with one another should be responsible for the low disease incidence and resistant severity status of variety Oniyere. Mean tuber weight loss after inoculation and incubation with B. theobromae for 2 weeks was 0% and infection range over the three treatments was low, that is 1.21 to 2.95% with no significant differences. Mean tuber weight per plant was in the range 0.88kg to 1.35kg with no significant differences between treatments. The 1.20ml/l -1 bounty fertilizer treatment gave equivalent yield of 13.46 tons ha -1 . Bounty fertilizer at 0.60ml/l -1 or 1.20ml/l -1 is recommended for local varieties of white guinea yam in South West Nigeria especially where monocropping is desired.