Effect of Tissue Perfusion on Microwave Ablation: Experimental in Vivo Study in Porcine Kidneys

Sommer, Christof M.; Koch, Vitali; Pap, Bence; Bellemann, Nadine; Holzschuh, M.; Gehrig, Tobias; Shevchenko, Maxym; Arnegger, Florian; Nickel, Felix; Mogler, Carolin; Zelzer, Sascha; Meinzer, Hans Peter; Stampfl, Ulrike; Kauczor, Hans Ulrich; Radeleff, Boris

doi:10.1016/j.jvir.2011.07.020

Cited by 19 publications

(7 citation statements)

References 34 publications

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“…Microwave ablations with more than 3 minutes time duration can induce coagulation zones with desirable shape for clinical practice. Consistent with previous studies [30,32], the shapes among different output powers were comparable. The characteristics of the coagulation zone should be considered when microwave ablation is applied in clinical practice.…”

Section: Discussionsupporting

confidence: 91%

“…Theoretically, a smaller ablation volume can be achieved in high blood-flow tissues relative to low blood flow tissues. Sommer CM and colleagues found that after interruption of blood flow, microwave ablation areas were significantly larger than those achieved without limitation of tissue perfusion [30]. Our ex vivo model was not influenced by blood-flow, and we can’t ablate completely different tissues in clinical practice.…”

Section: Discussionmentioning

confidence: 89%

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Comparison of Ablation Zones among Different Tissues Using 2450-MHz Cooled-Shaft Microwave Antenna: Results in Ex Vivo Porcine Models

et al. 2013

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BackgroundFor complete tumor ablation in different tissues, it is necessary to investigate the exact coagulation zone of microwave ablation in different tissues. The aim of this study was to compare the extent of microwave ablation zone in muscle, liver and adipose tissue in ex vivo porcine models and assess the shape of microwave coagulation zone among these tissues.Materials and MethodsMicrowave ablations were performed in ex vivo porcine muscle, liver and adipose tissue using 2450-MHz cooled-shaft microwave antenna. The content of water, fat and protein in these three tissues was determined. Two power increments (40 and 80 W) and five time increments (1, 3, 5, 7, and 10 minutes) were used in this study. Diameters and shapes of the ablation zones were assessed on gross specimens.ResultsThe average percentages of water, fat and protein in these three tissues were significantly different (P < 0.001), respectively. The long-axis and short-axis diameters among these three tissues at each time-power combination were not significantly different (P > 0.05). The coagulation zones were all elliptical in muscle, liver and adipose tissue. When microwave ablation was performed in the tissue containing both muscle and adipose tissue, the coagulation zone was also elliptical. Regardless of the output power, the ellipticity index (EI) value of 1 minute treatment duration was higher than that of 10 minutes treatment duration (P < 0.05). Furthermore, the EI value did not decrease significantly when the treatment duration was more than 5 minutes (P > 0.05).ConclusionThe extent of microwave ablation zones was not significantly different among completely different tissues. Microwave ablations with ≥ 5 minutes time duration can induce coagulation zones with clinical desirable shape. Future clinical studies are still required to determine the role of microwave ablation in different tissues.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 89%

Comparison of Ablation Zones among Different Tissues Using 2450-MHz Cooled-Shaft Microwave Antenna: Results in Ex Vivo Porcine Models

et al. 2013

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“…The results of experimental studies on MWA ablation-zone size in perfused versus nonperfused kidneys confirmed the reduced susceptibility of MWA to heat-sink effects caused by large adjacent vessels or the renal collecting system. 18 Besides hemorrhage, thermal damage during RFA can result in the scarring and stricture of the pyelon, 17 leading to urinary obstruction and/or urinoma. Possible infection may ultimately require permanent nephrostomy for treatment.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Antegrade Pyeloperfusion to Protect the Renal Pelvis in Kidney Microwave Ablation Using an In Vivo Swine Model

Isfort

Penzkofer²,

Tanaka³

et al. 2013

Investigative Radiology

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“…One of the critical parameters, that is, blood perfusion has been ignored in ex-vivo trials, which may hinder the actual clinical output. 29 In this research work, a novel minimally invasive helical antenna (NMHA) is designed without matching circuit requirements has been presented along with the study of the effect on ablation due to various physical and thermal properties of a biological system. An external tap in the antenna is used for impedance matching.…”

Section: Introductionmentioning

confidence: 99%

“…Recent advancements in MWA are devoted to studying the effect on ablation zone due to inconsistent thermal and physical characteristics of the tissue arising from temperature variation during ablation. One of the critical parameters, that is, blood perfusion has been ignored in ex‐vivo trials, which may hinder the actual clinical output 29 …”

Section: Introductionmentioning

confidence: 99%

Design of a novel externally‐tapped intertwining helical antenna for microwave ablation and its statistical analysis on tissue model

Singh

Yadav

2021

Int J RF Mic Comp-Aid Eng

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Cancer is the leading cause of death in recent centuries and microwave ablation (MWA) has been evolving to thermally treat cancerous tissue through cell necrosis and is also a promising substitute to radio frequency ablation. In this article, a novel normal-mode helical antenna based MWA probe is investigated for the effect on ablation diameter in the presence of five critical parameters. The antenna consists of an intertwining helix structure mounted on a very small ground plane. An external tapping is used to match the antenna impedance. In the proposed design at the center frequency, a reflection coefficient of more than 23 dB without insertion into the tissue model and a reflection coefficient of more than 14 dB with insertion into the tissue model have been observed at 5 GHz frequency. The gain and percentage bandwidth of the antenna is 0.6 dB and 10%, respectively. At 20 W power, a maximum ablation diameter of 32 mm (transversal-T) and 44 mm (axial-A) is reached within 5 min of application time at a distance of 30 mm from the probe. Further, the L27 Taguchi's orthogonal array has been employed to study the effect on ablation diameter by varying five thermo-electrical parameters. The outcome of Taguchi's analysis has been ranked according to the contribution of each parameter. Further, F-and p-value test has been employed using analysis of variance to study the significance of each parameter on ablation diameter.

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Effect of Tissue Perfusion on Microwave Ablation: Experimental in Vivo Study in Porcine Kidneys

Cited by 19 publications

References 34 publications

Comparison of Ablation Zones among Different Tissues Using 2450-MHz Cooled-Shaft Microwave Antenna: Results in Ex Vivo Porcine Models

Comparison of Ablation Zones among Different Tissues Using 2450-MHz Cooled-Shaft Microwave Antenna: Results in Ex Vivo Porcine Models

Efficacy of Antegrade Pyeloperfusion to Protect the Renal Pelvis in Kidney Microwave Ablation Using an In Vivo Swine Model

Design of a novel externally‐tapped intertwining helical antenna for microwave ablation and its statistical analysis on tissue model

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