Effect of tocopherol on the properties of Pluronic F127 microemulsions: Physico-chemical characterization and in vivo toxicity

Rahdar, Addas; Taboada, Pablo; Hajinezhad, Mohammad Reza; Barani, Mahmood; Beyzaei, Hamid

doi:10.1016/j.molliq.2018.12.074

Cited by 57 publications

(32 citation statements)

References 31 publications

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“…Generally, an ideal drug carrier should have high encapsulation efficiency (EE) [ 33 , 37 , 38 , 39 ]. High EE (above 70%) can increase the efficacy of the drug delivery system and decrease the side effects of the drug [ 33 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

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Lignin-Stabilized Doxorubicin Microemulsions: Synthesis, Physical Characterization, and In Vitro Assessments

et al. 2021

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Encapsulation of the chemotherapy agents within colloidal systems usually improves drug efficiency and decreases its toxicity. In this study, lignin (LGN) (the second most abundant biopolymer next to cellulose on earth) was employed to prepare novel doxorubicin (DOX)-loaded oil-in-water (O/W) microemulsions with the aim of enhancing the bioavailability of DOX. The droplet size of DOX-loaded microemulsion was obtained as ≈ 7.5 nm by dynamic light scattering (DLS) analysis. The entrapment efficiency (EE) % of LGN/DOX microemulsions was calculated to be about 82%. In addition, a slow and sustainable release rate of DOX (68%) was observed after 24 h for these microemulsions. The cytotoxic effects of standard DOX and LGN/DOX microemulsions on non-malignant (HUVEC) and malignant (MCF7 and C152) cell lines were assessed by application of a tetrazolium (MTT) colorimetric assay. Disruption of cell membrane integrity was investigated by measuring intracellular lactate dehydrogenase (LDH) leakage. In vitro experiments showed that LGN/DOX microemulsions induced noticeable morphological alterations and a greater cell-killing effect than standard DOX. Moreover, LGN/DOX microemulsions significantly disrupted the membrane integrity of C152 cells. These results demonstrate that encapsulation and slow release of DOX improved the cytotoxic efficacy of this anthracycline agent against cancer cells but did not improve its safety towards normal human cells. Overall, this study provides a scientific basis for future studies on the encapsulation efficiency of microemulsions as a promising drug carrier for overcoming pharmacokinetic limitations.

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Section: Resultsmentioning

confidence: 99%

“…The effect of different parameters on the release of active ingredients from nanocarriers has been evaluated in several studies [ 37 , 38 , 39 ]. Thus, the release of DOX from the NPs was found to follow an anomalous type of behavior.…”

Section: Resultsmentioning

confidence: 99%

Lignin-Stabilized Doxorubicin Microemulsions: Synthesis, Physical Characterization, and In Vitro Assessments

et al. 2021

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“…D-limonene-loaded niosomes were dissolved in 1 mL of ethanol and then centrifuged at 15000 rpm for 30 min (model 5415D, Eppendorf, Germany) (27). D-limonene absorbance in the supernatant was measured spectrophotometrically at 255 nm (Agilent Technologies, Cary 60, USA).…”

Section: Methodsmentioning

confidence: 99%

In vitro cytotoxicity assay of D-limonene niosomes: an efficient nano-carrier for enhancing solubility of plant-extracted agents

et al. 2019

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The low solubility of the plant-extracted agent like D-limonene in cancer therapy is a critical problem. In this study, we prepared D-limonene-loaded niosomes (D-limonene/Nio) for cancer therapy through in vitro cytotoxicity assay of HepG2, MCF-7, and A549 cell lines. The niosomal formulation was prepared by film hydration technique with Span® 40: Tween® 40: cholesterol (35:35:30 molar ratio) and characterized for vesicle distribution size, morphology, entrapment efficiency (EE%), and in vitro release behaviour. The obtained niosomes showed a nanometric size and spherical morphology with EE% about 87 ± 1.8%. Remarkably prolonged release of D-limonene from niosomes compared to free D-limonene observed. The loaded formulation showed significantly enhanced cytotoxic activity with all three cancer cell lines (HepG2, Macf-7 and A549) at the concentration of 20 μM. These results indicated that niosome loaded with phytochemicals can be a promising nano-carrier for cancer therapy applications

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“…Data from the literature highlight the association between myopia and the level of Vitamin D in the blood, but also the role of other vitamins (A, B, E, etc. ), all of these substances (and many more others) having a decisive role in the visual acuity [24][25][26][42][43][44]. The Vitamin D deficiencies with an inappropriate diet, the lack of sufficient exposure to the sun, represent the favourable factors for the appearance of the decreased value of Vitamin D in the blood [45,46].…”

Section: Resultsmentioning

confidence: 99%

The Correlation of Vitamin D Level with Refractive Errors in Disabled Paediatric Patients

Holhos¹,

Bungău²,

Ţiţ³

et al. 2020

Rev. Chim.

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Refractive errors are the most prevalent ocular disorders in paediatric ophthalmology having a higher occurrence in children with disabilities. This paper evaluated the refractive status of the disabled children and identified the influence of Vitamin D on this status. The study group was represented by 160 children (80 clinically healthy � group 0, 80 having different physical and/or mental disabilities � group 1) with ages between 5-16 years old, ophthalmologically examined between January 2019-January 2020. The prevalence of refractive errors was analysed according to the blood level of Vitamin D; the prevalence of the identified refractive errors was 35% in the group of children with disabilities (16% myopia, 14% astigmatism, 5% hyperopia) and 36% in the group of clinically healthy children (16% astigmatism, 10% myopia, 10% hyperopia). In group 1, an acceptable level (20-30 ng/mL) of Vitamin D was found in 61.54% of children with myopia, 25% in those with hyperopia, and 18.18% in those with astigmatism, the rest showing insufficiency of Vitamin D. Both children with disabilities/clinically healthy shown ocular refractive errors, the difference between the two groups being statistically insignificant (1%). The presence of Vitamin D in the blood in normal or insufficient levels suggests a strong correlation of its levels with the appearance of ocular refraction disorders.

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Effect of tocopherol on the properties of Pluronic F127 microemulsions: Physico-chemical characterization and in vivo toxicity

Cited by 57 publications

References 31 publications

Lignin-Stabilized Doxorubicin Microemulsions: Synthesis, Physical Characterization, and In Vitro Assessments

Lignin-Stabilized Doxorubicin Microemulsions: Synthesis, Physical Characterization, and In Vitro Assessments

In vitro cytotoxicity assay of D-limonene niosomes: an efficient nano-carrier for enhancing solubility of plant-extracted agents

The Correlation of Vitamin D Level with Refractive Errors in Disabled Paediatric Patients

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