Effect of Toki‐shakuyaku‐san on acetylcholine level and blood flow in dorsal Hippocampus of intact and twice‐repeated ischemic rats

Hatip‐Al‐Khatib, Izzettin; Hatip, Funda Bölükbaşı; Yoshimitsu, Yoshitaka; Iwasaki, Katsunori; Egashira, Nobuaki; Liu, An Xin; Mishima, Kenichi; Fujiwara, Michihiro

doi:10.1002/ptr.2050

Cited by 11 publications

(10 citation statements)

References 13 publications

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“…TSS activates cholinergic [10–14] and monoaminergic [12, 13, 15] neurons and has a protective effect on amyloid β [16, 17], an antioxidant effect [18, 19], and an antiapoptosis action [12]. Several clinical studies have also suggested that TSS improves cognitive impairment in dementia, MCI, and poststroke patients [20–22].…”

Section: Introductionmentioning

confidence: 99%

Effect of Toki-Shakuyaku-San on Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment and Alzheimer's Disease

Matsuoka

Narumoto

Shibata

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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The aim of this study was to examine the effect of toki-shakuyaku-san (TSS) on mild cognitive impairment (MCI) and Alzheimer's disease (AD) using single-photon emission computed tomography (SPECT). All subjects were administered TSS (7.5 g/day) for eight weeks. SPECT and evaluations using the Mini Mental State Examination (MMSE), Neuropsychiatric Inventory, and Physical Self-Maintenance Scale were performed before and after treatment with TSS. Three patients with MCI and five patients with AD completed the study. No adverse events occurred during the study period. After treatment with TSS, regional cerebral blood flow (rCBF) in the posterior cingulate was significantly higher than that before treatment. No brain region showed a significant decrease in rCBF. TSS treatment also tended to improve the score for orientation to place on the MMSE. These results suggest that TSS could be useful for treatment of MCI and AD.

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Section: Introductionmentioning

confidence: 99%

Effect of Toki-Shakuyaku-San on Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment and Alzheimer's Disease

Matsuoka

Narumoto

Shibata

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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“…Moreover, DSS modulates metabolism of monoamine neurotransmitters including increasing the content of norepinephrine (NE), DA and 5-hydroxytryptamine (5-HT) in brains of aged mice while protecting the cortical ultrastructure [41], which may be the major mechanism of DSS for improving memory dysfunction induced by alcohol. In addition, DSS not only increased ACh and blood flow in intact rats, it also increased ACh in ischemic rats in the dorsal hippocampus (DH), suggesting that DSS can improve the cognition [49].…”

Section: The Effect On the Neurotransmitter And The Central Nervous Smentioning

confidence: 99%

Danggui-Shaoyao-San: New Hope for Alzheimer's Disease

Fu¹,

Wang²,

Wang³

et al. 2016

Aging and disease

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Danggui-Shaoyao-San (DSS), also called Toki-shakuyaku-san (TJ-23) or Dangguijakyaksan (DJS), is a well-known herbal formula (Angelica sinensis (Oliv.) Diels., Ligusticum chuanxiong Hort., Paeonia lactiflora pall., Poria cocos (Schw.) Wolf, Alisma orientalis (Sam.) Juzep., Atractylodes macrocephala Koidz.), which has been widely used in oriental countries for the treatment of various gynecological diseases. Recent studies show that DSS has an effect on free radical-mediated neurological diseases and exhibits anti-inflammatory and antioxidant activities and reduces cell apoptosis in the hippocampus. In addition, DSS mediates the modulation of central monoamine neurotransmitter systems and ameliorates dysfunction of the central cholinergic nervous system and scopolamine-induced decrease in ACh levels. DSS improves the function of the dopaminergic, adrenergic, and serotonergic nervous systems. Interestingly, DSS can alleviate cognitive dysfunction of Alzheimer's disease (AD) patients, suggesting that it is a useful therapeutic agent for AD. This paper reviews the mechanism of DSS for the treatment of AD.

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“…A multitude of cellular and molecular mechanisms have been associated with neuroprotection of DSS that include modulation of neurotransmitter, regulation of cerebral blood flow and reduction of NO and malondialdehyde [13,17,19]. In this study, we first reported that DSS improved neuronal outcome through the promotion of angiogenesis and neurogenesis.…”

Section: Discussionmentioning

confidence: 88%

“…In recent years, its use is extended to brain diseases. For example, Hatip-Al-Khatib et al reported that DSS increased acetylcholine and blood flow in global cerebral ischemia rats [19]. A clinical study also showed that DSS increased regional cerebral blood flow in the posterior circulation in patients with mild cognitive impairment and Alzheimer's disease [12].…”

Section: Discussionmentioning

confidence: 99%

“…The medicinal serum of DSS could reduce hypoxia-induced myocardial cell injury too [18]. DSS was also reported to increase blood flow in the hippocampus after global cerebral ischemia [19]. All these studies suggest that DSS is a potential agent for the treatment of ischemic/hypoxia-induced injury.…”

Section: Aging and Disease • Volume 6 Number 4 August 2015 246mentioning

confidence: 99%

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Herbal Formula Danggui-Shaoyao-San Promotes Neurogenesis and Angiogenesis in Rat Following Middle Cerebral Artery Occlusion

Ren¹,

Wang²,

Li³

et al. 2015

Aging and disease

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Current studies demonstrated that traditional Chinese herbal formula Danggui-ShaoyaoSan (DSS) is not only used for the treatment of menstrual disorder, but has also found its use in neurological diseases. However, the neuroprotective role of DSS on ischemia-induced brain injury is still unclear. The aim of the present study is to explore the effect of DSS in ischemic brain injury. Total 30 adult female Sprague-Dawley rats underwent 90 min transient middle cerebral artery occlusion (MCAO). DSS (600 mg/kg) was administered through the intragastric route at the time of reperfusion and then performed every day thereafter until sacrifice. Results showed that DSS treatment significantly improved neurobehavioral outcomes (N=10 per group, P<0.05). Immunohistochemical staining showed that microvessel density in the perifocal region of DSS-treated rats was significantly increased compared to the saline-treated group (N=4 per group, P<0.01). Similarly, the numbers of BrdU + /DCX + cells in the subventricular zone were increased in DSS-treated rats compared to the saline-treated group (P<0.05). Furthermore, we demonstrated that DSS treatment activated vascular endothelial growth factor (N=4 per group，P<0.05) and promoted eNOS phosphorylation (N=4 per group，P<0.05). Thus, we concluded that DSS promoted focal angiogenesis and neurogenesis, and attenuated ischemia-induced brain injury in rats after MCAO, suggesting that DSS is a potential drug for ischemic stroke therapy.

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Effect of Toki‐shakuyaku‐san on acetylcholine level and blood flow in dorsal Hippocampus of intact and twice‐repeated ischemic rats

Cited by 11 publications

References 13 publications

Effect of Toki-Shakuyaku-San on Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment and Alzheimer's Disease

Effect of Toki-Shakuyaku-San on Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment and Alzheimer's Disease

Danggui-Shaoyao-San: New Hope for Alzheimer's Disease

Herbal Formula Danggui-Shaoyao-San Promotes Neurogenesis and Angiogenesis in Rat Following Middle Cerebral Artery Occlusion

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