Effect of Toothpaste Containing Novamin on Streptococcous Mutans Count in Dental Plaque of High Caries Risk Children (Randomized Controlled Clinical Trial)

Comparative Evaluation of Remineralization and Antimicrobial Efficacy of Maximum Fluoride Containing Toothpastes Available in India - In-Vivo Study

“…The lack of efficacy of remineralising toothpastes suggests that its usefulness is limited only to remineralisation of carious teeth, and not in reducing microbial load. Contrary to our results, Mohamed et al [34] reported novamin-containing toothpaste showed to be an effective antimicrobial agent in S.mutans count reduction. P. Stoor et al concluded that the bioactive glass paste appears to possess a broad antimicrobial effect on microorganisms of both supra-and sub-gingival plaque [35].…”

“…P. Stoor et al concluded that the bioactive glass paste appears to possess a broad antimicrobial effect on microorganisms of both supra-and sub-gingival plaque [35]. The antibacterial effect of Novamin is attributed to the increased pH in the aqueous(saliva) oral environment due to the release of alkaline ions and the constant release of sodium ions that increases the osmotic pressure and positive pressure on the bacterial cell membrane [34]. Our findings of negative antibacterial effect of novamin, however, could be related to the invitro conditions in our investigation, as the osmotic pressure shift could not occur due to the absence of aqueous media.…”