Effect of topical administration of 1% morphine sulfate solution on signs of pain and corneal wound healing in dogs

Stiles, Jean; Honda, Christopher N.; Krohne, Sheryl G.; Kazacos, Evelyn A.

doi:10.2460/ajvr.2003.64.813

Cited by 64 publications

(105 citation statements)

References 25 publications

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“…For all treatment protocols, this initial increase in corneal sensitivity was followed by a steady decrease (Table 1).The magnitude and significance of the initial increase and subsequent decrease is different between drugs, but this trend is consistently observed for each specific antiinflammatory drug evaluated.The control of corneal pain has limited options, as topical sodium channel blockers, such as proparacaine and tetracaine, are not acceptable due to their limited duration of activity and epitheliotoxic effects (Grant and Acosta, 1994;Herring et al, 2005;Venturi et al, 2016). Topical morphine has been shown to provide acceptable analgesia without a delay of corneal epithelialization (Peyman et al, 1994;Stiles et al, 2003;Clark et al, 2011); however, the corneal analgesic effectiveness in dogs has recently come into question (Thomson et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs

Cantarella¹,

Oliveira²,

Dorbandt³

et al. 2017

Open Vet J.

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To evaluate corneal sensitivity by using the Cochet-Bonnet® esthesiometer in normal canine eyes at different time points following instillation of three different topical non-steroidal anti-inflammatory drugs (flurbiprofen sodium 0.03%, diclofenac sodium 0.1% and ketorolac tromethamine 0.5%) and benzalkonium chloride 0.01%. Six healthy mixed breed dogs from the same litter were used in two different stages. First, one drop of flurbiprofen sodium 0.03% and diclofenac sodium 0.1% in each eye; second, one drop of ketorolac tromethamine 0.5% and benzalkonium chloride 0.01% in each eye. Baseline esthesiometry was obtained before eye drop application and every 15 minutes thereafter until a total of 105 minutes of evaluation time. A one-week interval was allowed between the two treatment phases. Statistical analysis was used to compare means according to time of evaluation and drug used. Diclofenac sodium 0.1% decreased corneal sensitivity at 75 and 90 minutes (P > 0.015) with possible interference on neuronal nociceptive activity and analgesic effect while ketorolac tromethamine 0.5% did not show any variation for esthesiometry means along the evaluation. Flurbiprofen sodium 0.03% resulted in increased esthesiometry values 30 minutes after instillation (P > 0.013), increasing corneal sensitivity and possibly producing a greater irritant corneal effect over its analgesic properties. Benzalkonium chloride 0.01% significantly increased corneal sensitivity at 15 minutes of evaluation (P > 0.001), most likely resulting from its irritating effect. Esthesiometry did not allow a definite conclusion over the analgesic effect of the NSAIDs tested; however it was effective in detecting fluctuations in corneal sensitivity.

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Section: Introductionmentioning

confidence: 99%

Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs

Cantarella¹,

Oliveira²,

Dorbandt³

et al. 2017

Open Vet J.

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“…To prevent disturbing the dogs, the investigator was distant from the dogs during the measurement of pain score and eye blink frequency. CTT was measured by use of a Cochet-Bonnet aesthesiometer (Luneau ophtalmologie, Chartres Cedex, France) [11,21,23] following the evaluation of pain score and eye blink frequency. CTT measurements were conducted in the dogs sitting or in sternal recumbency with minimum head restraint or eyelid manipulation.…”

Section: Scoring Of Pain and Examinationsmentioning

confidence: 99%

“…one of them, morphine sulfate, is often used systemically to control pain, but has the potential for undesirable side effects. on the other hand, it is demonstrated that topical use of morphine relieves pain associated with corneal wounds in dogs [21] and rats [22]. Additionally, morphine did not cause a delay in corneal wound healing when it was used topically [21].…”

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confidence: 98%

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Effect of Topical Administration of 0.8% Nalbuphine on the Cornea in Dogs after Phacoemulsification

Lee

Lin

Chi

et al. 2013

The Journal of Veterinary Medical Science

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ABSTRACT. It is suggested that topical application of opioids may provide localized analgesia without delay in corneal wound healing. This study was designed to evaluate the effect of topical application of 0.8% nalbuphine on post-operative ocular pain in dogs. Twelve eyes from 11 dogs undergoing phacoemulsification cataract surgery were divided into a nalbuphine group (n=6) and saline group (n=6). Postoperatively, the nalbuphine group received 0.1 ml of topical 0.8% alkalinized nalbuphine (pH 5.6) every 8 hr, and the saline group received 0.1 ml of topical saline (pH 5.9) as a placebo. All dogs received systemic postoperative pain managements with oral tramadol (4 mg/kg) and prednisolone (0.5 mg/kg) every 8 hr. All dogs received pre-and post-ophthalmic examinations. Pain was scored in the dogs using a pain scoring system modified from the University of Melbourne pain scale at 15, 30 and 60 min following the topical treatment on days 1 and 2 (24 and 48 hr after surgery). Eye blink frequency and corneal touch threshold (CTT) were recorded at the same time. There was no statistical difference in the pain score between groups. Significant decreases in CTT, blepharospasm and eye blink frequency were observed after the topical nalbuphine treatment. This indicated that topical application of 0.8% nalbuphine solution can produce a rapid reduction of corneal discomfort in dogs.

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“…A central corneal epithelial wound was made as described previously (Stiles et al, 2003). Each dog was anesthetized with an intramuscular injection of ketamine hydrochloride (10 mg/kg) and xylazine (6 mg/kg) and with topical 1% lidocaine hydrochloride.…”

Section: Corneal Epithelial Woundmentioning

confidence: 99%

Treatment of corneal epithelial wounds in dogs using basic fibroblast growth factor

Hu¹,

Ding²,

Chen³

et al. 2009

Vet. Med. - Czech

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An experimental study examined the effect of basic fibroblast growth factor (bFGF) on the healing of corneal epithelial wounds in dogs. A corneal wound was made on one eye from each of 40 dogs with a corneal trephine (6 mm diameter). Four concentrations of bFGF (0, 0.1, 0.5, and 1.0 µg/ml) were applied to the affected eyes three times daily. Fluorescein staining was used to assess the closure of the corneal epithelial wounds. The morphological characteristics were determined on histological examination. The wound healing rate was significantly greater in the bFGF-treated group compared with controls 1, 3, 5, and 7 days (P < 0.01) after the topical administration of bFGF. Both 0.5 and 1.0 µg/ml bFGF increased the wound healing rate significantly (at Days 3 and 5, P < 0.05) compared to 0.1 µg/ml bFGF. Moreover, two control cases still showed poor healing 10 days after the corneal wound. None of the eyes developed corneal clouding or neovascularization during the experiment. The histological examination showed more epithelial layers, a more regular rearrangement, and fewer inflammatory cells in the epithelium of the bFGF-treated group; the epithelium was reconstructed more quickly in the bFGF-treated group compared with the control group. These results suggest that bFGF promotes canine corneal epithelial wound healing effectively, making bFGF suitable for curing canine corneal epithelial wounds.

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Effect of topical administration of 1% morphine sulfate solution on signs of pain and corneal wound healing in dogs

Abstract: Topical use of 1% MSS in dogs with corneal ulcers provided analgesia and did not interfere with normal wound healing. Both mu and delta opioid receptors were identified in normal corneas of dogs, although the mu receptors were present only in small numbers.

Cited by 64 publications

References 25 publications

Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs

Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs

Effect of Topical Administration of 0.8% Nalbuphine on the Cornea in Dogs after Phacoemulsification

Treatment of corneal epithelial wounds in dogs using basic fibroblast growth factor

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