Effect of topical application of dipyrone on dental sensitivity reduction after in-office dental bleaching

Rezende, Márcia; Chemin, Kaprice; Vaez, Savil Costa; Peixoto, Aline Carvalho; Rabelo, Jéssica de Freitas; Braga, Stella Sueli Lourenço; Faria-e-Silva, André Luís; Silva, Gisele Rodrigues da; Soares, Carlos José; Loguércio, Alessandro Dourado; Reis, Alessandra

doi:10.1016/j.adaj.2017.11.003

Cited by 31 publications

(33 citation statements)

References 27 publications

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“…These results may indicate that oral anti-inflammatory drugs may not influence the response of the pulp tissue. In this way, a previous study used a non-steroidal anti-inflammatory topically in a failed attempt to reduce post-operative bleaching sensitivity (16). However the medication was used before bleaching gel.…”

Section: Topical Anti-inflammatory Action In Bleached Rat Teethmentioning

confidence: 99%

“…A recently published trial evaluated the prior topic use of dipyrone and also did not found any reduction on tooth sensitivity caused by in-office bleaching (16). However, Otosporin® is a drug with anti-inflammatory action differentiated by its strong penetrating power into tissue, which guarantees it to be better and fast acting (17).…”

Section: Introductionmentioning

confidence: 99%

“…In the study of Rezende et al (16), the topical use of dipyrone was before of the bleaching session and is possible that the use of the topical anti-inflammatory after the bleaching session will have a better result, which has not yet been evaluated. Knowledge of the mechanism of action of Otosporin® over the pulp tissue of bleached teeth is important, especially the modulation of the inflammatory process.…”

Section: Introductionmentioning

confidence: 99%

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In Vivo Study of the Action of a Topical Anti-Inflammatory Drug In Rat Teeth Submitted To Dental Bleaching

et al. 2018

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Bleaching gel containing hydrogen peroxide (H2O2) cause damages in pulp tissue. This study investigated the action of a topical anti-inflammatory, the Otosporin®, in rats’ bleached teeth with the null hypothesis of which the Otosporin® is no able to minimize the pulp inflammation that bleaching gel generates. The rat’s molars were divided into groups: BLE: bleached (35% H2O2 concentration /single application of 30 min); BLE-O: bleached followed by Otosporin® (10 min); and control: placebo gel. In the second day after dental bleaching, the rats were killed, and the jaws were processed for hematoxylin-eosin and immunohistochemistry analysis for tumor necrosis factor alpha (TNF-α), interleukin (IL)-6 and IL-17. The data collected were subjected to Kruskal-Wallis and Dunn statistical tests with at a 5% level of significance (p<0.05). The BLE group had moderate to strong inflammation in the occlusal third of the coronary pulp, with necrotic areas; and BLE-O, mild inflammation (p<0.05). There was a significant difference in the occlusal and middle thirds of the coronary pulp between the BLE with BLE-O and control groups (p<0.05). There was no difference in the cervical third (p>0.05). The BLE group had a high immunoexpression of TNF-α than BLE-O and control groups (p<0.05), with moderate and mild immunoexpression, respectively. Regarding IL-6 and IL-17, the BLE group had higher immunoexpression than control (p<0.05); the BLE-O was similar to the control (p>0.05). The topical anti-inflammatory Otosporin® can reduce pulp inflammation after dental bleaching in the rat teeth.

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Section: Topical Anti-inflammatory Action In Bleached Rat Teethmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In Vivo Study of the Action of a Topical Anti-Inflammatory Drug In Rat Teeth Submitted To Dental Bleaching

et al. 2018

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“…[7][8][9] Therefore, some alternatives have been tested to reduce or even eliminate this adverse effect. Among them, the administration of oral systemic drugs able to inhibit the release of inflammatory mediators, 8,[10][11][12][13][14] and topical application of desensitizing/remineralizing agents 9,[15][16][17] are the most frequently evaluated. However, despite the ease of administration and good patient acceptance, the use of systemic drugs has not shown satisfactory results in reducing the risk and intensity of TS.…”

mentioning

confidence: 99%

Effect of topical application of nanoencapsulated eugenol on dental sensitivity reduction after in‐office dental bleaching: a randomized, triple‐blind clinical trial

Vilela

Rezende²,

Terra

et al. 2021

J Esthet Restor Dent

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Purpose: This randomized, split-mouth, triple-blind clinical study evaluated the effect of application of nanoencapsulated eugenol (NE) on the absolute risk and intensity of tooth sensitivity (TS) resulting from in-office bleaching.Methods: Fifty-six patients received a NE in one hemiarch and a placebo gel in the other hemiarch, determined by random sequence, before in-office bleaching. A visual analogue scale (VAS) (0-10) and a numeric rating scale (NRS) (0-4) were used to record TS during bleaching and 1 and 48 h after bleaching. The tooth color was performed from baseline to 2 weeks after bleaching with shade guides (ΔSGU) and a spectrophotometer (ΔE ab , ΔE 00, and WI D ). The TS was assessed through the McNemar test (α = 0.05) and by the Wilcoxon signed-rank test (NRS) and paired t-test (VAS). The paired test-t was employed to compare the color changes (ΔSGU and ΔE ab , ΔE 00, and WI D ). The significance level was 5%.Results: No statistically significant difference was found in the absolute risk or intensity of TS between both groups (p > 0.05). A significant color change was observed in both groups (p > 0.05). Conclusion:Administration of the gel containing NE before the in-office dental bleaching did not reduce the TS and did not interfere in the bleaching effect.Clinical relevance statement: The use of desensitizing gel containing NE did not reduce in-office bleaching-induced tooth sensitivity.

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“…Another explanation is that drugs administrated via oral and presenting systemic action have a limited effect on the pulp tissue, and topical application of anti-inflammatories could be more effective to minimize the inflammatory process (27,28). However, a prior large multicentric clinical trial did not find any effect of a single preemptive topical application of dipyrone over the enamel on post-bleaching tooth sensitivity (29). Although the main outcomes of the study were related to tooth sensitivity since the effects of preemptive administration of an anti-inflammatory was evaluated, the color changes following the bleaching procedures were also assessed.…”

Section: N a D D I T I O N T O P H A R M A C O K I N E T I C S Favomentioning

confidence: 99%

Preemptive Use of Piroxicam on Tooth Sensitivity Caused By In-Office Bleaching: A Randomized Clinical Trial

et al. 2019

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This clinical trial evaluated the effect of preemptive use of the non-steroidal anti-inflammatory drug piroxicam in a single dose 30 min prior to in-office bleaching on the prevention of tooth sensitivity (TS) reported by patients. Fifty patients were submitted to two sessions of in-office tooth bleaching with 35% hydrogen peroxide used for 2 sessions, each consisting of a single 45-min application, with an interval of 7 days between session. Thirty minutes prior to the procedure, the patient randomly received a single dose of piroxicam (200 mg) or placebo in a double-blind, randomized, crossover design. The TS was evaluated using verbal rate (VRS) and visual analog (VAS) scales during the bleaching procedure and at 24 h after each session. The color changes were assessed by the Vita Bleachedguide scale 1 week after each bleaching session. Risk of TS was calculated from the VRS and analyzed by the McNemar test, while the level of TS was analyzed by the Mann-Whitney test. For the VAS, t-tests were used to compare data from the treatments at each assessment time. Data regarding color changes were subjected to Wilcoxon and Mann-Whitney tests (α=0.05). The preemptive administration of piroxicam did not affect the risk and level of TS compared to placebo, irrespective of the assessment time. The treatment sequence did not affect bleaching effectiveness. In conclusion, the administration of a single dose of piroxicam prior to in-office tooth bleaching was unable to significantly reduce the risk and level of TS.

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Effect of topical application of dipyrone on dental sensitivity reduction after in-office dental bleaching

Cited by 31 publications

References 27 publications

In Vivo Study of the Action of a Topical Anti-Inflammatory Drug In Rat Teeth Submitted To Dental Bleaching

In Vivo Study of the Action of a Topical Anti-Inflammatory Drug In Rat Teeth Submitted To Dental Bleaching

Effect of topical application of nanoencapsulated eugenol on dental sensitivity reduction after in‐office dental bleaching: a randomized, triple‐blind clinical trial

Preemptive Use of Piroxicam on Tooth Sensitivity Caused By In-Office Bleaching: A Randomized Clinical Trial

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