Effect of topical calcipotriol, betamethasone dipropionate and their combination in the treatment of localized vitiligo

Abstract

Combined therapy appeared to give a significantly faster onset of repigmentation along with better stability of the achieved pigmentation and with lesser number of side-effects.

Comparative Efficacy of the Combination of Topical Betamethasone Dipropionate and Calcipotriene with Betamethasone Dipropionate and Calcipotriene Alone in the Treatment of Localized Vitiligo

“…These findings were consistent with other studies like Kumaran et al and Parsad et al 15,16 A trial was conducted by Kumaran et al to evaluate the effect of topical calcipotriol ointment (0.005%) and betamethasone dipropionate (0.05%) cream, given alone or in combination, in treatment of localized vitiligo. Group I patients were treated with betamethasone dipropionate (0.05%) cream twice daily.…”

Role of Corticosteroids in Treatment of Vitiligo

“…They also showed that this combination is able to minimize corticosteroid side effects (Kumaran et al, 2006). In other study, Travis and Siverberg revealed that calcipotriene in combination with corticosteroids could repigment vitiligenous lesions, even in those with previous treatment failure with corticosteroids (Travis & Siverberg, 2004).…”

“…Fluticasone propionate is the first carbothioate corticosteroids, classified as a potent, characterized by high lipophilicity, high glucocorticoid receptor binding and activation, and a rapid metabolic turnover in skin; thus, it has low cutaneous and systemic side effects, even in sensitive areas such as face, the eyelids and intertriginous regions (Kumaran, 2006). It seems that it can be a good treatment option for vitiligo.…”

“…Kumaran, in one sudy revealed that combination therapy with topical corticosteroids and calcipotriol produced a significantly faster onset of repigmentation along with better stability of repigmentation (Kumaran, 2006).…”

“…Combination therapy with corticosteroid and calcipotriol, not only produces faster onset of repigmetion in vitiligo patients, but also decreases the incidence rate of side effects (Kumaran, 2006).…”