Effect of topical chamomile on immunohistochemical levels of IL-1β and TNF-α in 5-fluorouracil-induced oral mucositis in hamsters

Association of tumor necrosis factor-α polymorphism with chemotherapy-induced oral mucositis in patients with esophageal cancer

“…It has been reported in several human studies that the levels of pro-inflammatory cytokines are increased in the blood and saliva of patients during cancer treatment (14)(15)(16). Other studies using animal models have shown evidence of changes in the serum level and tissue expression of nuclear factor κ-B and the pro-inflammatory cytokines [TNF-α, interleukin (IL)-1β and IL-6) following administration of chemotherapeutic drugs (14,(17)(18)(19). The rs1800629 polymorphism of TNF-α has been reported to be associated with hypercytokinemia, such as sepsis (20)(21)(22); this Data are presented as median values (range) or as absolute numbers (%).…”

Immunohistochemical Study of the Effect of Chamomile Extract on 5-Fluorouracil Induced Intestinal Mucositis in Albino Rats

“…Curra et al [39] study the effect of topical chamomile (mouthwash) on immunohistochemical levels of IL-1β and TNF-α in 5-fluorouracilinduced oral mucositis in hamsters. They found the group treated with chamomile had lower scores for both pro-inflammatory cytokines.…”

Effect of Rice Cell-Derived Human Granulocyte-Macrophage Colony-Stimulating Factor on 5-Fluorouracil-Induced Mucositis in Hamsters

“…Continued research of effective treatments for oral mucositis is needed. 32,34) N-Linked carbohydrate moieties of hGM-CSF play a significant role in the biological specific activity in vitro and the adsorption rate from hypodermis and the clearance rate from bloodstream in vivo. 25,26) It was founded that rice cell derived hGM-CSF has higher glycosylation ratio and its ratio influence a pharmaceutical potency of rhGM-CSF.…”

“…Oral mucositis is considered a common debilitating complication of chemotherapy. [32][33][34] The primary symptoms of oral mucositis are erosive and ulcerative lesions of the oral mucosa. The aim of treatment for oral mucositis is generally relieving symptoms and adjust possible infections.…”