Effect of topical chickpea oil (Cicer arietinum L.) on knee osteoarthritis: A randomized double-blind controlled clinical trial

Abbasifard, Mitra; Bazzaz, Avid; Bazmandegan, Gholamreza; Rezaeian, Mohsen; Saeed-Askari, Pooya; Mahmoodian, Hamed; Zareshahi, Rahele

doi:10.1016/j.eujim.2020.101076

Cited by 8 publications

(5 citation statements)

References 18 publications

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“…Our study's findings are consistent with other research indicating that topical application of pistachio oil preparation reduces pain in patients, as assessed by the VAS scale or WOMAC index. This supports the beneficial role of P. vera as an herbal strategy for osteoarthritis, as demonstrated in Abbasifard et al's study on the effects of chickpea oil in OA patients (15). These findings provide support for the effectiveness of herbal medicine in managing chronic OA.…”

Section: Discussionsupporting

confidence: 81%

“…Studies have demonstrated the potential of curcumin in alleviating symptoms of OA by exerting anti-inflammatory, anti-oxidative stress, and anti-catabolic effects, inhibiting inflammatory pathways, COX-2, and matrix metalloprotease-9 (25,26). Another study by Abbasifard et al found that topical application of chickpea oil provided pain relief, reduced motion stiffness, and improved activity in patients with knee OA (15). Evidence suggests that other herbal preparations, such as capsaicin and Symphytum officinale, may also have protective effects in treating OA (27,28).…”

Section: Discussionmentioning

confidence: 99%

“…Patients with the following co-morbidities were excluded from the study: inflammatory diseases, malignancy or serious illness, symptoms or history of liver or kidney failure, recent consumption of oral corticosteroids within the past four weeks or corticosteroid injections within the past six months, continuous use of medicinal herbs, sensitivity to pistachios, presence of fever, dissatisfaction with participation, failure to adhere to study protocols, observation of side effects related to pistachio oil, regular daily use of analgesics, advanced stage of the disease, use of other topical medications at the site of pistachio oil application, oral use of analgesics and other effective compounds for OA treatment up to 10 days prior to the study, skin disease or infection, or wound at the site of pistachio ointment application, and pregnancy (15). Patients who met the inclusion and exclusion criteria were eligible for participation in the trials.…”

Section: Exclusion Criteriamentioning

confidence: 99%

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Topical Pistacia vera L. Seed Oil Preparation and Its Effects on Knee Osteoarthritis Through a Randomized Double-blind Controlled Clinical Trial

Abbasifard,

Kamiab,

Bazmandegan

et al. 2023

Jundishapur J Nat Pharm Prod

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Background: Osteoarthritis (OA) is a degenerative joint disease that globally affects the elderly, leading to pain and disability. Herbal medications and alternative therapies have demonstrated positive effects on arthritis management. Pistacia vera has traditionally been used for inflammatory conditions and has also shown antinociceptive effects. Objectives: Given the limited available scientific evidence, our randomized controlled trial aimed to assess the potential protective role of topical P. vera seed oil preparation in patients with knee OA. Methods: A total of 89 patients with knee OA (n = 89) were randomly allocated into three groups: Placebo, piroxicam, and P. vera. The topical formulations were administered twice daily over a period of three months. Pain level, patient health status, and performance were evaluated using the visual analog scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Statistical analysis was performed using SPSS software. Results: The application of P. vera ointment demonstrated pain reduction in patients, as indicated by VAS and WOMAC assessments. Additionally, WOMAC scores showed that P. vera ointment alleviated motion stiffness and improved activity difficulties in patients (P < 0.001). In certain parameters, the topical application of P. vera showed greater effectiveness in treating knee OA than piroxicam (P < 0.05). Conclusions: Pistacia vera ointment shows promise as a potential therapeutic option for osteoarthritis, effectively addressing the detrimental effects of the disease. Further experimental and clinical studies are warranted to elucidate its efficacy and safety profile.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Exclusion Criteriamentioning

confidence: 99%

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Topical Pistacia vera L. Seed Oil Preparation and Its Effects on Knee Osteoarthritis Through a Randomized Double-blind Controlled Clinical Trial

Abbasifard,

Kamiab,

Bazmandegan

et al. 2023

Jundishapur J Nat Pharm Prod

Self Cite

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“…A 2016 Cochrane systematic review on topical NSAIDs for chronic musculoskeletal pain was included [ 16 ]. This review was updated with an additional 42 studies: 14 compared to placebo [ 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 ], four compared to oral NSAIDs [ 84 , 85 , 86 , 87 ], five compared to topical NSAIDs [ 88 , 89 , 90 , 91 , 92 ], and 19 compared to other topical drugs [ 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 ].…”

Section: Resultsmentioning

confidence: 99%

Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022)

Shi

Shao

et al. 2023

JCM

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(1) Background: Topical non-steroidal anti-inflammatory drugs (NSAIDs) are one of the primary drugs for treating musculoskeletal pain. However, there are currently no evidence-based recommendations about drug selection, drug administration, drug interactions, and use in special populations or other pharmacology-related content of such medications. To this end, the Chinese Pharmaceutical Association Hospital Pharmacy Professional Committee developed multidisciplinary guidelines on using topical NSAIDs to treat musculoskeletal pain. (2) Methods: The guidelines development process followed the World Health Organization guideline development handbook, the GRADE methodology, and the statement of Reporting Items for Practice Guidelines in Healthcare. The guideline panel used the Delphi method to identify six clinical questions to be addressed in the guidelines. An independent systematic review team conducted a systematic search and integration of evidence. (3) Results: Based on the balance between the benefits and harms of an intervention, the quality of the evidence, patient preferences and values, and resource utilization, the guideline panel developed 11 recommendations and nine expert consensuses on using topical NSAIDs to treat acute and chronic musculoskeletal pain. (4) Conclusions: Based on the effectiveness and overall safety of topical NSAIDs, we recommend patients with musculoskeletal pain use topical NSAIDs and suggest high-risk patients use topical NSAIDs, such as those with other diseases or receiving other concurrent treatments. The evidenced-based guidelines on topical NSAIDs for musculoskeletal pain incorporated a pharmacist perspective. The guidelines have the potential to facilitate the rational use of topical NSAIDs. The guideline panel will monitor the relevant evidence and update the recommendations accordingly.

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“…The content of Chickpea oil or Cicer arietinum has been proven to contain analgesic and anti-inflammatory effects. However, the analgesic properties of chickpeas can only provide an effect by penetrating the skin through the help of a mixture of sesame (Abbasifard et al, 2020).…”

Section: Chickpea Oilmentioning

confidence: 99%

The Effectiveness of Topical Plant Oils Against Pain in Knee Osteoarthritis Patient

Saragih

Masfuri

Gayatri

2022

NLJ

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The prevalence of knee osteoarthritis (OA) patients will increase along with the escalation of life expectancy. Complementary and alternative therapies like topical plant oils have been used to reduce pain in several countries. However, the effectiveness of this topical plant oil is not yet known, especially in patients with knee OA in Indonesia. This study aims to assess the effectiveness of topical plant oils on pain for knee OA patients through literatures review. The literature search was conducted using 5 electronic databases, namely PubMed, ScienceDirect, Emerald Insight and Cochrane (Central). The search for literature that matches the topic of literature review using PICO, after that a review is carried out using the PRISMA method. On initial search found 412 journals, then filtered according to the inclusion criteria, which are full text, English, 2015-2020 publications, and Randomized Control Trial design. The journals be obtained were filtered again by the title and the abstract then read the full text. There were 7 selected journals that matched to the inclusion criteria and research purposes after a critical assessment using the Joanna Briggs Institute (JBI) checklist for Randomized Controlled Trials. Topical plant oils are effective in reducing joint pain without side effects. These positive findings can be applied in Indonesia. Combination with other non-pharmacological therapies is suggested in future studies to increase the effectiveness of topical plant oils for knee OA patients in reducing joint pain.

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Effect of topical chickpea oil (Cicer arietinum L.) on knee osteoarthritis: A randomized double-blind controlled clinical trial

Cited by 8 publications

References 18 publications

Topical Pistacia vera L. Seed Oil Preparation and Its Effects on Knee Osteoarthritis Through a Randomized Double-blind Controlled Clinical Trial

Topical Pistacia vera L. Seed Oil Preparation and Its Effects on Knee Osteoarthritis Through a Randomized Double-blind Controlled Clinical Trial

Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022)

The Effectiveness of Topical Plant Oils Against Pain in Knee Osteoarthritis Patient

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