Effect of topical dorzolamide on optic nerve head blood flow

Pillunat, Lutz E.; Böhm, Andreas; Koller, Andrea; Kg, Schmidt; Klemm, M.; Richard, Gisbert

doi:10.1007/s004170050268

Cited by 53 publications

(28 citation statements)

References 19 publications

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“…31,32 In NTG patients, dorzolamide significantly reduced arteriovenous passage (AVP) time in the superior temporal retina and improved contrast sensitivity at both 3 and 6 cycles/degree. 33,34 Other studies on retrobulbar vessels 35 and at the retinal level 36 did not find any significant effect of dorzolamide instillation on OBF in healthy subjects. The fixed combination of timolol and dorzolamide (D/T) has been proven to be as effective in lowering IOP as the concomitant use of the two molecules and more effective than either in monotherapy.…”

Section: Introductionmentioning

confidence: 84%

The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients

Rolle

Tofani

Brogliatti

et al. 2008

Eye

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Purpose To compare the effect of dorzolamide hydrochloride 2%, timolol maleate 0.5%, and their fixed combination on intraocular pressure (IOP) and retinal and optic nerve head haemodynamics in primary open-angle glaucoma patients. Methods Twenty-eight patients with early-moderate glaucomatous damage treated with b-blockers (46 months) with IOP values ranging from 18 to 22 mmHg at trough participated in this trial. After a 4-week washout period, patients were randomized in two groups: group I started with dorzolamide 2% monotherapy and group II with timolol 0.50% monotherapy for 4 weeks. After this period, both groups switched to dorzolamide/ timolol fixed combination for 4 weeks. IOP, ocular diastolic perfusion pressure (ODPP), heart rate, and Scanning Laser Doppler Flowmetry measurements at the peripapillary retina and neuroretinal rim were taken at T0 (enrolment), T1 (wash out), T2 (monotherapy), and T3 (dorzolamide/timolol). Data were compared between different study times. Statistical analysis was conducted using a paired t-test. Results Between T1 and T3, IOP decreased significantly in group I (À21.40%) (Po0.001) and in group II (À21.25%) (Po0.001). At the same time intervals, blood flow increased significantly at rim level for group I ( þ 30.03%) (Po0.05) and also when all patients were considered (rim þ 17.99%) (Po0.05). Between T1 and T3, we also observed a significant increase of ODPP in group I ( þ 7.24%) (Po0.01) and in group II ( þ 6.08%) (Po0.05) and when all patients were considered ( þ 8.43%) (Po0.01). Conclusions Dorzolamide/timolol fixed combination increased blood flow significantly at the neuroretinal rim showing a combination of hypotensive and haemodynamic effects.

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Section: Introductionmentioning

confidence: 84%

The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients

Rolle

Tofani

Brogliatti

et al. 2008

Eye

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“…In contrast, carteolol, betaxolol and nipradilol reportedly increased ONH blood flow in humans (Tamaki et al, 1997a(Tamaki et al, , 1997bTamaki et al, 1999;Mizuno et al, 2002). It was reported that dorzolamide, a topical CAI, had no significant effect on ONH blood flow in healthy subjects but increased ONH blood flow in glaucoma patients (Pillunat et al, 1999;Fuchsjäger-Mayrl et al, 2005;Rolle et al, 2008). To the best of our knowledge, there have been few reports on the effect of brinzolamide, another topical CAI, on ONH blood flow in humans (Iester et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Optic Nerve Head Blood Flow in Glaucoma

Sugiyama¹,

Shibata²,

Kojima³

et al. 2011

The Mystery of Glaucoma

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“…[15][16][17][18][19][20] However, not all studies have reported a positive outcome. [21][22][23] Relatively few studies have evaluated the effect of topical brinzolamide upon OBF in glaucoma patients.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Long-Term Effects of Dorzolamide 2% and Brinzolamide 1%, Each Added to Timolol 0.5%, on Retrobulbar Hemodynamics and Intraocular Pressure in Open-Angle Glaucoma Patients

Martínez

Sánchez-Salorio²

2009

Journal of Ocular Pharmacology and Therapeutics

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Purpose: To compare the effect on the retrobulbar hemodynamics and intraocular pressure (IOP) of dorzolamide 2% and brinzolamide 1%, each added to timolol 0.5% in patients with primary open-angle glaucoma (POAG). Methods: 146 POAG patients were prospectively randomized to receive either dorzolamide 2% or brinzolamide 1% BID, each added to timolol 0.5%, during a 60-month evaluator-masked study. At baseline and every 6 months for 60 months, we measured the retrobulbar hemodynamic parameters in the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (SPCA) using color Doppler imaging (CDI), intraocular pressure (IOP), and blood pressure measurements. Results: Dorzolamide signifi cantly increased the end-diastolic velocity (EDV) in the OA in 1.22 cm/s, 95% confi dence interval (95% CI) 0.90-1.56 cm/s, P < 0.001 and reduced the resistivity index (RI) in the OA in 0.04 units, 95% CI 0.03-0.05, P < 0.001. None of the retrobulbar parameters changed signifi cantly on therapy with brinzolamide when the results were analyzed at month 60. Both dorzolamide and brinzolamide signifi cantly decreased IOP (-4.3, 95% CI -4.5 to -4.2 mmHg and -4.3, 95% CI -4.4 to -4.2 mmHg, respectively). Dorzolamide significantly reduced the RI in the OA from 0.74 (0.02) to 0.70 (0.02), CRA from 0.66 (0.02) to 0.62 (0.02), and SPCA from 0.66 (0.02) to 0.62 (0.02), P < 0.001, respectively. Conclusions: Our results suggest augmented retrobulbar blood fl ow after 5 years of treatment with dorzolamide but not with brinzolamide, each added to timolol, in POAG patients.

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Effect of topical dorzolamide on optic nerve head blood flow

Cited by 53 publications

References 19 publications

The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients

The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients

Optic Nerve Head Blood Flow in Glaucoma

A Comparison of the Long-Term Effects of Dorzolamide 2% and Brinzolamide 1%, Each Added to Timolol 0.5%, on Retrobulbar Hemodynamics and Intraocular Pressure in Open-Angle Glaucoma Patients

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