Effect of Topical Fluoride Treatments on Fluoride Distribution during in vitro Caries-Like Lesion Formation

Clarkson, Brian H.; Hansen, Svend E.; Js, Wefel

doi:10.1159/000261118

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…Investigations using demineralized enamel, which represent active caries, are thus more predictive of potential anticaries efficacy. The importance of fluoride uptake in demineralized enamel has also been noted by Clarkson et al 36 in which he found the smaller the lesions, the more fluoride they contained. This effect is most likely due to the overall reversal of the lesions associated with the increased levels of fluoride and mineral within the body of the lesions.…”

Section: Discussionsupporting

confidence: 57%

Anticaries Potential of Commercial Dentifrices as Determined by Fluoridation and Remineralization Efficiency

Casals

Boukpessi²,

McQueen³

et al. 2007

The Journal of Contemporary Dental Practice

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Aim:The aim of this in vitro study was to investigate fluoride uptake in human enamel after use of o commercially available toothpastes containing different fluoride compounds, or combinations of fluoride actives formulated into a single product, as a means of determining the efficiency of each formula for delivering caries preventing fluoride to demineralized (caries active) enamel.Group 6: A placebo (formulated the same as the USP Reference Standard toothpaste with the exception that it contained < 1 ppm F). Cores 3 mm in diameter were removed from erupted human enamel specimens (extracted by local oral surgeons for orthodontic reasons) and stored in 1% Thymol solution prior to use. They were ground and polished to remove the natural fluoride rich enamel layer, then exposed to a demineralization solution, and assessed for surface microhardness to enable randomization for use in the study. Each group of five specimens underwent a daily pH cycling procedure that involved exposure to pooled human saliva (refreshed three times daily). The groups were then exposed to dentifrice slurries four times daily for one minute per exposure and to a demineralization solution for three hours. The cycling procedure was repeated for five days. Specimens were again analyzed for surface microhardness and fluoride uptake upon completion of five days of treatment. Abstract © Seer Publishing

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Section: Discussionsupporting

confidence: 57%

Anticaries Potential of Commercial Dentifrices as Determined by Fluoridation and Remineralization Efficiency

Casals

Boukpessi²,

McQueen³

et al. 2007

The Journal of Contemporary Dental Practice

View full text Add to dashboard Cite

show abstract

“…4,[13][14][15] The ability of thymol to perforate cell membranes is believed to be the principle mode of action of this substance. 16 In addition to its anti-microbial action, another factor that may contribute to the efficacy of thymol as a disinfectant is the length of exposure of the samples to the thymol solution.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of techniques for the disinfection of artificial sub-surface dentinal caries lesions and their effect on demineralization and remineralization in vitro

Preston

Higham

Smith

2007

Journal of Dentistry

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“…Some fluorine ions act on hydroxyapatite to generate hydrofluoroapatite and fluoroapatite. Moreover, it is thought that precipitated calcium fluoride is gradually dissolved by the saliva to improve the crystallinity and inhibit the solubility of the hydroxyapatite that composes the enamel, and increase the acid-resistance of the enamel 15,16) . In short, APF is an acidic preparation used for precipitating calcium fluoride.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Vickers hardness, microstructure, and surface roughness of dentin after initial dissolution by acidulated phosphate-fluoride

Okamoto

Matsuya

2012

Pediatric Dental Journal

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Acidulated phosphate-fluoride (APF) is widely used for the prevention of enamel caries. The topical application of fluoride is a promising treatment for improving the acid-resistance of tooth, promoting its remineralization, and improving its crystallinity. APF contains a high concentration of fluorine ions (9,000 ppm); it first decalcifies the apatite in dentin, generating calcium and phosphate ions, which bind to fluoride ions, thus precipitating calcium fluoride. APF is prepared as an acidic solution (pH 3.5) and is used to reinforce the enamel. However, dentin is less resistant to acid than enamel. As such, APF treatment at the same acidity carries a risk of weakening the dentin after application. In many cases, wedge-shaped defect (WSD), root caries, and attrition can cause dentin exposure, to which the APF can attach. Therefore, in this study, we analyzed the effect of APF treatment on dentin by measuring Vickers hardness, making observations with scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM), and measuring average surface roughness (Ra). The findings of this study suggested that an acidulated phosphate fluoride (APF) treatment of 3 min or longer caused marked dissolution of dentin and posed the risk of deterioration of its initial strength. Therefore, careful management is required to preclude dentin dissolution when performing APF treatment for preventing dental caries. Knutson et al. 7) later proposed applying sodium fluoride solution. In the 1950s, Howell et al. 8) proposed the use of stannous fluoride solutions, and in the 1960s, Brudevold et al. 9,10) proposed the use of acid phosphate-fluoride (APF) solutions. These topical fluoride application methods are still commonly used today. These methods have many benefits, including formation of fluoroapatite, improvement of the crystallinity of the enamel, promotion of remineralization, and antimicrobial activity 11-14) , and are thus considered an effective means of preventing dental caries. APF is prepared as an acidic solution (pH 3.5) with a high concentration of fluorine ions (9,000 ppm). Once applied to a tooth, it initially decalcifies the surface. Calcium ions and phosphate ions are then generated; calcium ions bind to fluoride ions, and this leads to the precipitation of calcium

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Effect of Topical Fluoride Treatments on Fluoride Distribution during in vitro Caries-Like Lesion Formation

Cited by 6 publications

References 9 publications

Anticaries Potential of Commercial Dentifrices as Determined by Fluoridation and Remineralization Efficiency

Anticaries Potential of Commercial Dentifrices as Determined by Fluoridation and Remineralization Efficiency

The efficacy of techniques for the disinfection of artificial sub-surface dentinal caries lesions and their effect on demineralization and remineralization in vitro

Assessment of Vickers hardness, microstructure, and surface roughness of dentin after initial dissolution by acidulated phosphate-fluoride

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