Effect of topical honey on limitation of radiation-induced oral mucositis: an intervention study

Effects of Kurdistan Honey on the Tongue of Chemotherapy Treated Albino Rats (Immunohistochemical Study)

“…Several studies were used topically applied honey for treatment of oral mucositis like Biswal et al [15], Motallebnejad et al [10], Rashad et al [16], Khanal et al [17], Abdulrhman et al [18] and Sedighi et al [19]. They showed that topically applied honey produced faster healing in patients with oral mucositis.…”

Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis

“…local anesthesia, analgesics, antiinflammatory drugs, oral care, midline radiation blocks, benzydamine, oral cryotherapy using ice, exposure to soft Laser, and systemic administration of keratinocyte growth factor (palifermin) [3,4,9]. Local application of honey appears to be a very promising RIOM local therapy as well [10][11][12][13]. Although pharmacological and non-pharmacological therapies were applied for RIOM, yet, no single therapy was identified to significantly minimize and/or repair RIOM.…”

“…Although pharmacological and non-pharmacological therapies were applied for RIOM, yet, no single therapy was identified to significantly minimize and/or repair RIOM. Such expected significant therapeutic benefit would be mediated through reducing the injury severity and duration to a clinically relevant extent [2,4,5,12,. The inflammatory nature of the RIOM directs the current studies towards finding a convenient antiinflammatory therapy for such tissue injury.…”

Evidence-Based Practices for Mucositis

“…[33] Yara iyileşmesinde etkili olan Bal'ın ise mukozitin önlenmesinde yararlı olduğuna dair kanıtlar bulunmakta olup [1] , yapılan bir çalışmada, mukozit şiddetini azalttığı belirtilmiştir. [34] Yapılan çalışmalarda, balın yanı sıra propolis ve arı sütünün mukozit yönetiminde tamamlayıcı ve destekleyici olarak kullanılması önerilmektedir. [35,36] Ancak kanıtlar yeterli değildir.…”