Effect of Topical Prostaglandin Analogue Therapy on Central Corneal Thickness: A Systematic Review

Kim, Jae-Yun; Yim, Hyeon Woo

doi:10.3390/jcm12010044

Cited by 6 publications

(5 citation statements)

References 37 publications

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“…The short‐term effects may differ from the long‐term effects. Furthermore, meta‐analyses have shown that topical PGAs significantly decrease central corneal thickness 23,24 . A previous in vitro study showed a decrease in collagen type I levels and corneal thickness in rabbit eyes treated with PGAs and a corresponding decline in corneal thickness in patients treated with PGAs 25 .…”

Section: Discussionmentioning

confidence: 99%

Corneal thickness and endothelial change after use of ocular hypotensive agents

Lai,

Kuo

et al. 2024

The Kaohsiung J of Med Scie

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Corneal transplantation can restore visual function when visual impairment is caused by a corneal disease. However, this treatment is associated with the scarcity of cornea donors. The suitability of corneal donation from patients with glaucoma using ocular hypotensive agents (OHAs) is controversial. This study aimed to elucidate changes in corneal thickness, corneal endothelial cell density, and corneal endothelial cell hexagonality after OHA use in patients with primary open‐angle glaucoma. We retrospectively reviewed the data of 53 glaucoma suspect eyes without OHA use and 106 primary open‐angle glaucoma eyes under OHA use. All participants underwent corneal parameter assessment using SP‐3000P (Topcon Corp., Tokyo, Japan) at the time of diagnosis and the final visit. The OHA dose and timing of use were recorded. The ocular hypotensive agents score (OHAS) was determined based on the number, formula, frequency, and duration of OHA use. Baseline data showed no significant differences between the two groups with and without OHA use. At the final visit, the OHA‐treated group showed significantly lower corneal thickness and corneal endothelial cell density than those of the control group. A weak positive correlation between the OHAS and changes in corneal endothelial cell hexagonality was noted. However, no correlation was observed between the OHAS and changes in corneal thickness or endothelial cell density. In conclusion, patients with glaucoma and using OHAs should undergo the corneal structural properties examinations before donation to ensure the quality of donor cornea.

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Section: Discussionmentioning

confidence: 99%

Corneal thickness and endothelial change after use of ocular hypotensive agents

Lai,

Kuo

et al. 2024

The Kaohsiung J of Med Scie

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“…Another limitation in our study is that a majority of HMG participants were treated with prostaglandin analogues (PGAs). Notably, prior studies have suggested a potential impact of PGAs on anterior segment structures in glaucoma patients [ 37 , 38 ]. However, future longitudinal studies with larger samples are needed to prove these effects and to determine the requisite time for manifestation in myopic patients.…”

Section: Discussionmentioning

confidence: 99%

Anterior Scleral Thickness and Anterior Segment Biometrics Measured with Swept Source Ocular Coherence Tomography in High Myopic Eyes with and without Glaucoma: A Comparative Study

Kudsieh,

Vega-González,

Bryan

et al. 2024

Diagnostics

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Background: To assess the anterior scleral thickness (AST), Schlemm’s canal diameter (SCD), trabecular meshwork diameter (TMD) and conjunctiva tenon capsule thickness (CTT) in high myopic (HM) subjects and HM subjects with glaucoma (HMG) compared to control eyes. Methods: One hundred and twenty eyes were included, and AST at 0, 1, 2 and 3 mm from the scleral spur, SCD, TMD and CTT were measured. Results: Mean age was 64.2 ± 11.0 years, and the temporal SCD and temporal TMD were significantly longer in the HMG subjects compared to the controls (380.0 ± 62 μm vs. 316.7 ± 72 μm, p = 0.001) and (637.6 ± 113 μm vs. 512.1 ± 97 μm, p = 0.000), respectively. There were no significant differences between the HM and HMG subjects in SCD and TMD (all p > 0.025). Compared to the HM subjects, the temporal AST0 (432.5 ± 79 μm vs. 532.8 ± 99 μm, p = 0.000), temporal AST1 (383.9 ± 64 μm vs. 460.5 ± 80 μm, p = 0.000), temporal AST2 (404.0 ± 68 μm vs. 464.0 ± 88 μm, p = 0.006) and temporal AST3 (403.0 ± 80 μm vs. 458.1 ± 91 μm, p = 0.014) were significantly thinner in the HMG group. No differences were found between the CTT in the three groups (all p > 0.025). Conclusions: Our data indicate a thinner AST in HMG subjects and no differences in SCD and TMD between HM and HMG subjects.

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“…There are studies on changes in corneal thickness (which is part of the fibrous capsule of the eye) during prostaglandin treatment. 14,15 This fact suggests a close relationship between the thickness of the supporting membrane of the eye andthe level of IOP. In our opinion, thinning of the anterior segment of the sclera can be achieved surgically (rounded supraciliary non-penetrating sclerectomies -imitation of anteriorscleral staphyloma in advanced myopia and glaucoma.…”

Section: What Do We Offer?mentioning

confidence: 97%

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2024

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Primary open-angle glaucoma (POAG) is one of the main causes of irreversible blindness. There is no single theory of POAG development. The trigger of the disease is unknown. Treatment is ineffective.The author's concept: the trigger of the glaucomatous process is a genetically programmed small distance between the ciliary body and the lens equator (less than the age-related norm) in the presbyopic period of life. This causes weakness of accommodation and triggers further pathological changes in the eye. For proof of concept, large-scale studies of the anterior segment of the eye (ultrasound biomicroscopy) should be performed in presbyopes with ophthalmic hypertension, with and without POAG, with measurement of the distance "ciliary body -lens equator". Objective acomodometry is also necessary to determine the volume of accommodation in the above patients. In case of confirmation of the author's concept, a 3-component phased treatment of POAG is proposed: 1. Surgical expansion of the ciliary body ring (scleral thinning) -non-penetrating supraciliary sclerectomy or application of antimetabolites to the supraciliary sclera; 2. Phaco emulsification of the lens with implantation of an IOL model that maximizes the volume of pseudo -accommodation; 3. antiglaucomatous microinvasive surgery.

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Effect of Topical Prostaglandin Analogue Therapy on Central Corneal Thickness: A Systematic Review

Cited by 6 publications

References 37 publications

Corneal thickness and endothelial change after use of ocular hypotensive agents

Corneal thickness and endothelial change after use of ocular hypotensive agents

Anterior Scleral Thickness and Anterior Segment Biometrics Measured with Swept Source Ocular Coherence Tomography in High Myopic Eyes with and without Glaucoma: A Comparative Study

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