Effect of topical steroids on recently developed incomplete nasolacrimal duct obstruction: optical coherence tomography study

Yang, Moon Sik; Kim, Namju; Choung, Ho Kyung; Khwarg, Sang In

doi:10.1007/s00417-019-04392-1

Cited by 3 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the time of delayed tear clearance or damage to the ocular surface caused by harmful substances in the tears might be no significant difference. On the other hand, previous studies have reported that incomplete NLD increases blood flow resistance and tear stasis time [ 25 ], and the accumulated debris in the NLD enhances the malignant inflammatory cycle in the NLD mucosa [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Higher incidence of meibomian gland dysfunction in postmenopausal women with primary acquired nasolacrimal duct obstruction

Wang,

Jin,

Sheng

et al. 2024

Int Ophthalmol

View full text Add to dashboard Cite

Purpose This study aimed to investigate the incidence of meibomian gland dysfunction (MGD) in postmenopausal women with primary acquired nasolacrimal duct obstruction (PANDO) and enables ophthalmologists to pay attention to ocular surface damage before surgery. Methods 165 postmenopausal women with PANDO and 115 postmenopausal women with a normal lacrimal drainage system were enrolled in this prospective study. Based on the results of lacrimal duct irrigation and age, the participants were further subdivided. The incidence of different severities of MGD in different groups was calculated and analyzed by the chi-squared test. Results The incidence of MGD in the PANDO group was 81.21%, and in the control group, it was 46.96%, which was significantly higher in the presence of PANDO (p < 0.001). The incidence of severe MGD in the complete and incomplete PANDO groups was higher than that in the control group (all p < 0.05), and no significant differences were observed between the complete and incomplete PANDO groups. The incidence of moderate MGD was significantly higher in the complete PANDO group than in the control group (p < 0.001). When age was considered an independent variable, the results revealed a significant value for patients aged < 70 years (p < 0.001). Conclusions Our study revealed a prodominantly high incidence of MGD in postmenopausal women with PANDO, especially in a complete PANDO or aged < 70 years. Ophthalmologists need to pay close attention to MGD in postmenopausal women with PANDO.

show abstract

Section: Discussionmentioning

confidence: 99%

Higher incidence of meibomian gland dysfunction in postmenopausal women with primary acquired nasolacrimal duct obstruction

Wang,

Jin,

Sheng

et al. 2024

Int Ophthalmol

View full text Add to dashboard Cite

show abstract

“…This reaction can lead to progressive fibrosis, granuloma, or granulation tissue formation [ 18 – 20 ], eventually resulting in recurrent obstruction of the NLD [ 21 ]. We attempted to maximally expand the NLD mucosal lumen using a sequential dilatation technique and to suppress inflammatory swelling of the NLD mucosa by topical steroids [ 22 ], but a smaller bony NLD may limit the mucosal luminal expansion. The narrow NLD lumen increases flow resistance and tear stagnation that enhance the vicious inflammatory cycle in the NLD mucosa [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…We attempted to maximally expand the NLD mucosal lumen using a sequential dilatation technique and to suppress inflammatory swelling of the NLD mucosa by topical steroids [ 22 ], but a smaller bony NLD may limit the mucosal luminal expansion. The narrow NLD lumen increases flow resistance and tear stagnation that enhance the vicious inflammatory cycle in the NLD mucosa [ 22 ]. Further studies measuring the mucosal luminal diameter of NLD on postoperative CT will be helpful to validate our hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Bony nasolacrimal duct size and outcomes of nasolacrimal silicone intubation for incomplete primary acquired nasolacrimal duct obstruction

Yang

Kim

et al. 2022

PLoS ONE

Self Cite

View full text Add to dashboard Cite

Purpose To investigate the association between the bony nasolacrimal duct (NLD) size and outcomes of nasolacrimal silicone intubation for incomplete primary acquired nasolacrimal duct obstruction (PANDO). Methods Patients who underwent silicone intubation for incomplete PANDO and had undergone facial computed tomography (CT) were included. Surgical success was judged by both epiphora improvement and normalized tear meniscus height (TMH; < 300 μm) on anterior segment optical coherence tomography at 3 months after tube removal. The area, major axis diameter, and minor axis diameter of the elliptic bony NLD sections were measured in 1.0 mm-thick axial CT images. These bony NLD sizes were analyzed for associations with surgical success and TMH normalization. Results Eighty-one eyes of 48 patients were investigated. The smallest area and the smallest minor axis diameter were significantly larger in the success group (49 eyes), compared with those in the failure group (median smallest minor axis diameter: 4.7 mm vs. 3.8 mm, P = 0.008, Mann–Whitney U test). There was also a tendency for the TMH normalization rate to significantly increase as the smallest area and the smallest minor axis diameter increased (P = 0.028 and 0.037, respectively, Fisher’s 2 × 4 tests). Under multivariable logistic regression analysis using generalized estimating equation, a larger smallest minor axis diameter was associated with success of the nasolacrimal silicone intubation (odds ratio: 2.481, 95% confidence interval: 1.143–5.384). Conclusion Surgical success of the nasolacrimal silicone intubation in incomplete PANDO is associated with a larger smallest minor axis diameter of the bony NLD. This finding will help understand the pathophysiology of surgical failure after nasolacrimal silicone intubation.

show abstract

The effect of topical steroids and non-steroidal anti inflammatory drugs on epiphora of unknown cause: Optical coherence tomography study

Ceylanoglu

Şen

2023

Photodiagnosis and Photodynamic Therapy

View full text Add to dashboard Cite

Effect of topical steroids on recently developed incomplete nasolacrimal duct obstruction: optical coherence tomography study

Cited by 3 publications

References 39 publications

Higher incidence of meibomian gland dysfunction in postmenopausal women with primary acquired nasolacrimal duct obstruction

Higher incidence of meibomian gland dysfunction in postmenopausal women with primary acquired nasolacrimal duct obstruction

Bony nasolacrimal duct size and outcomes of nasolacrimal silicone intubation for incomplete primary acquired nasolacrimal duct obstruction

The effect of topical steroids and non-steroidal anti inflammatory drugs on epiphora of unknown cause: Optical coherence tomography study

Contact Info

Product

Resources

About