Effect of Topical Unoprostone Isopropyl on Optic Nerve Head Circulation in Controls and in Normal-Tension Glaucoma Patients

Kimura, Ikuo; Shinoda, Kei; Tanino, Tomihiko; Ohtake, Yuichiro; Mashima, Yukihiko

doi:10.1007/s10384-004-0208-2

Cited by 23 publications

(16 citation statements)

References 22 publications

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“…Another prostaglandin analog, unoprostone, which has been shown to lower IOP [73] and increase ONH circulation [74] in humans, has also been studied for its effect on TM, CB and RGC tissue after ET-1 administration. One study found that unoprostone blocks most of the ET-1-induced contraction of TM and CB as well as the majority of the ET-1-induced increase in intracellular calcium, lending further credence to the theory that prostaglandin analogs increase outflow of aqueous humor through Ca 2+ -sensitive pathways [75].…”

Section: Applications Of Endothelin In the Eyementioning

confidence: 99%

The role of endothelin in the pathophysiology of glaucoma

Good

Kahook

2010

Expert Opinion on Therapeutic Targets

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Overall, we believe that the body of evidence supports the following conclusions; i) endothelin is a potent vasoconstrictor that plays a role in ocular physiology, ii) endothelin may play a role in the pathophysiology of glaucoma and iii) modulation of the endothelin system with newly discovered potent antagonists holds promise in treating glaucoma through both pressure-dependent and pressure-independent pathways.

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Section: Applications Of Endothelin In the Eyementioning

confidence: 99%

The role of endothelin in the pathophysiology of glaucoma

Good

Kahook

2010

Expert Opinion on Therapeutic Targets

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“…50,51 After topical application of several prostaglandin analogues, a significant increase in ONHBF was found. 52,53 However, the impact of arachidonic acid metabolites on ONHBF during experimental changes in OPP must be investigated further.…”

Section: Discussionmentioning

confidence: 99%

Role of Nitric Oxide in Optic Nerve Head Blood Flow Regulation during Isometric Exercise in Healthy Humans

Schmidl¹,

Boltz

Kaya³

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. We determined whether administration of a nitric oxide synthase (NOS) inhibitor alters optic nerve head blood flow (ONHBF) regulation during isometric exercise in healthy subjects. METHODS.Our study was done in a randomized, placebocontrolled, double-masked, three-way crossover design. A total of 18 healthy subjects was randomized to receive either placebo, phenylephrine, or an inhibitor of NOS (L-NMMA) on three different study days. ONHBF was measured with laser Doppler flowmetry while the study participants performed isometric exercise (squatting). This was done before drug administration and during infusion of the study drugs. Mean arterial pressure (MAP) and IOP were measured noninvasively, and ocular perfusion pressure (OPP) was calculated as 2/3 MAP À IOP.RESULTS. The response in ONHBF to isometric exercise was less pronounced than the response in OPP, indicating for some autoregulatory capacity in the ONH. Administration of L-NMMA significantly decreased ONHBF at rest (P < 0.01). In contrast, inhibition of NOS did not alter the pressure-flow relationship in the ONH during an experimental increase in OPP compared to phenylephrine and placebo (P ¼ 0.37 between groups).CONCLUSIONS. The data of our study support previous findings that ONHBF is autoregulated during an experimental increase in OPP. Nitric oxide has an important role in basal ONHBF regulation, but seems not to be involved in the autoregulatory response during an increase in OPP induced by isometric exercise. (ClinicalTrials.gov number, NCT00806741.) (Invest Ophthalmol Vis Sci.

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“…The effectiveness of calcium channel blockers, which are being evaluated in clinical settings, [11][12][13][14][15][16] and of argon laser trabeculoplasty is questionable. In addition, these treatments are not widely accepted as beneficial for NTG.…”

mentioning

confidence: 98%

Phacoviscocanalostomy versus cataract surgery only in patients with coexisting normal-tension glaucoma: Midterm outcomes

Shoji¹,

Tanito²,

Takahashi³

et al. 2007

Journal of Cataract and Refractive Surgery

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Effect of Topical Unoprostone Isopropyl on Optic Nerve Head Circulation in Controls and in Normal-Tension Glaucoma Patients

Abstract: These results showed that unoprostone significantly increased microcirculation in the ONH in control subjects and in NTG patients without reducing the IOP significantly.

Cited by 23 publications

References 22 publications

The role of endothelin in the pathophysiology of glaucoma

The role of endothelin in the pathophysiology of glaucoma

Role of Nitric Oxide in Optic Nerve Head Blood Flow Regulation during Isometric Exercise in Healthy Humans

Phacoviscocanalostomy versus cataract surgery only in patients with coexisting normal-tension glaucoma: Midterm outcomes

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