Effect of torsemide and furosemide on clinical, laboratory, radiographic and quality of life variables in dogs with heart failure secondary to mitral valve disease

Peddle, Gordon D.; Singletary, Gretchen E.; Reynolds, Caryn; Trafny, Dennis J.; Machen, Maggie C.; Oyama, Mark A.

doi:10.1016/j.jvc.2012.01.003

Cited by 35 publications

(53 citation statements)

References 23 publications

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“…Development of renal injury or aggravation of pre-existing renal insufficiency is a common comorbidity in dogs with advanced heart failure, especially those on high doses of diuretics. In the aforementioned cross-over study, 13 BUN was significantly higher during torsemide administration in dogs with heart failure as opposed to furosemide. The restoration of diuretic responsiveness and the accompanying volume depletion that follows torsemide administration might increase risk for renal insufficiency, and care should be taken to limit or reduce administration of concurrent diuretics such as hydrochlorothiazide and to closely monitor renal function when administering torsemide.…”

Section: Discussionmentioning

confidence: 87%

“…In these and other cases managed by the authors, pet owners report notable increases in their dog's diuresis and water consumption following institution of torsemide. In a small prospective blinded cross-over study, 13 dogs with heart failure experienced significantly higher serum albumin and significantly lower urine specific gravity when receiving torsemide as compared to furosemide, suggesting that torsemide is associated with a relatively greater diuretic response. In the current retrospective case series, echocardiographic and laboratory parameters were not evaluated at each point in time, thus other potential reasons for our observations include sudden slowing or stabilization of disease progression or spontaneous resolution of pulmonary hypertension.…”

Section: Discussionmentioning

confidence: 99%

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Use of the loop diuretic torsemide in three dogs with advanced heart failure

Oyama

Peddle

Reynolds

et al. 2011

Journal of Veterinary Cardiology

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Use of the loop diuretic torsemide in three dogs with advanced heart failure

Oyama

Peddle

Reynolds

et al. 2011

Journal of Veterinary Cardiology

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“…Relief of pulmonary edema usually is accomplished with diuretics to decrease intravascular volume. 30 Oral diuretics are not ideal because of the likelihood of impaired gastrointestinal absorption and a relatively slow onset of action. A dosage-dependent venodilator effect has been observed with intravenous administration in humans.…”

Section: Radiographic Findingsmentioning

confidence: 99%

Valvular Heart Disease

Wey¹

2015

Small Animal Critical Care Medicine

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“…The superiority of torasemida over furosemide is due to its antifibrotic effects on the myocardium that appear to be mediated by the antagonism of aldosterone in a way similar to that of spironolactone. [48] Since sodium retention is a major contributor to congestion, the restriction of electrolytes in the diet has been used in the management of heart failure. It has recently become clear than the extreme restriction of sodium activates raas and may contribute to renal dysfunction, particularly when ace inhibitors are used.…”

Section: Treatmentmentioning

confidence: 99%

Myxomatous valve degeneration

et al. 2013

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Abstract. This review article is an analysis of the most recent published scientific articles about myxomatous valve degeneration (mvd) and was conducted over a five month period. The aim of this review is to consolidate information about the most recent medical developments in regards to myxomatous degeneration in the mitral valve. The authors of this article reached a consensus on both the development of the disease and the most effective type of diagnosis and treatment that is available today. Myxomatous valve degeneration is the most common heart disease in the canine population. It is identified by a loss of mechanical integrity in the heart due to structural changes in the valvular components. Degenerative changes occur due to an accumulation of mucopolysaccharides in the leaflets and chordae which affect the proper operation of the valve apparatus. This is caused by faulty coaptation of the leaflets, resulting in mitral or tricuspid regurgitation, dilated ventricles and annuli, which are lesions that eventually cause the rupture of the chordae tendineae, leading to complications or possibly death. Due to the gradual progression of the disease and the presence or absence of clinical signs, it is very important that veterinarians accurately diagnose and follow-up on these patients in order to achieve stabilization and provide a suitable prognosis and treatment plan. The current ideal treatment of the disease is a low-sodium diet, administration of the ace inhibitor (angiotensin-converting-enzyme inhibitor) spironolactone and a diuretic in order to reduce the presence of pulmonary edema and avoid the progression of the disease to congestive heart failure.Keywords: av valves, canine, heart, Myxomatous degeneration, treatment. Degeneração valvar mixomatosa. Um olhar nos últimos avanços em todos os aspectos da doençaResumo. Este artigo de revisão se realizou durante um período de cinco meses. Incluíram-se, neste, os últimos avanços publicados em artigos científicos. Conseguiu-se realizar um consenso quanto ao desenvolvimento da doença, ao tipo de diagnóstico mais adequado e ao tratamento que melhores resultados está mostrando na atualidade. O objetivo desta revisão foi conhecer as últimas atualizações sobre a degeneração valvular mixomatosa. A degeneração valvar mixomatosa é a doença cardíaca mais comum na população canina, na qual há uma perda da integridade mecânica devido a mudanças estruturais nos componentes valvulares. As mudanças se devem a uma acumulação de mucopolisacáridos nas cordas tendíneas e nas valvas as quais iniciam com falhas na coaptação das valvas gerando uma regurgitação mitral ou tricuspidiana, dilatação dos ventrículos e do anel valvular, levando a complicações ou morte do paciente. Devido ao progresso gradual das lesões na doença e à manifestação ou não de signos clínicos, o diagnóstico exato e seguimento apropriado desses pacientes é de grande importância para os médicos veterinários com o objetivo de prognosticar e instaurar o tratamento adequado. O melhor tratamento na atualidade para...

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Effect of torsemide and furosemide on clinical, laboratory, radiographic and quality of life variables in dogs with heart failure secondary to mitral valve disease

Cited by 35 publications

References 23 publications

Use of the loop diuretic torsemide in three dogs with advanced heart failure

Use of the loop diuretic torsemide in three dogs with advanced heart failure

Valvular Heart Disease

Myxomatous valve degeneration

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